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The oncogenic protein encoded by MCF2 is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. 再加上，我们可以发MCF2 蛋白 (3)和数多这个蛋白质的别的产品。
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Results support a role for Dbl oncogene (显示 RAB1A 抗体) in mammary epithelial cell differentiation and transformation and suggest the relevance of GEF (显示 SLC2A4RG 抗体) deregulation in tumor onset and progression.
Phosphoinositide 3-kinase C2beta regulates RhoA (显示 RHOA 抗体) and the actin cytoskeleton through an interaction with Dbl
Dbl is regulated by hamartin (显示 TSC1 抗体) through association with ezrin (显示 EZR 抗体).
proto-oncogene dbl is not a major target for sporadic testicular germ cell tumors
data describe 4 splicing variants of the human DBL (MCF-2) proto-oncogene (显示 RAB1A 抗体) that show different tissue distributions and guanine nucleotide exchange factor (显示 RASGRF1 抗体) specificities
provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways
These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 (显示 CDC42 抗体) by Dbl is dependent on functional ERM (显示 ETV5 抗体) proteins and is important for directional cell migration.
Galphaq (显示 GNAQ 抗体) directly activates p63RhoGEF and Trio (显示 TRIO 抗体) via a conserved extension of the Dbl homology-associated pleckstrin (显示 PLEK 抗体) homology domain
Nm23-H1 (显示 NME1 抗体) can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 (显示 CDC42 抗体) and possibly other Rho family members through interaction with Dbl-1
The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.
Oncogene MCF2 (oncogene DBL)
, proto-oncogene DBL
, proto-oncogene MCF-2