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MXD4 is a member of the MAD gene family . 再加上，我们可以发MAX Dimerization Protein 4 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal MXD4 Primary Antibody for ELISA, WB - ABIN249681
Hurlin, Quéva, Koskinen, Steingrímsson, Ayer, Copeland, Jenkins, Eisenman: Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. in The EMBO journal 1996
The E3 ligase activity of c-IAP1 (显示 BIRC2 抗体) was not required for downregulation of Mad4 expression.
regulation by a transcriptional repressor complex that contains Miz-1 (显示 ZBTB17 抗体) and c-Myc (显示 MYC 抗体)
Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells.
replicative senescence-specific factors may block c-Myc (显示 MYC 抗体) inhibition of Miz-1 (显示 ZBTB17 抗体) activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc (显示 MYC 抗体) target genes
during embryonic hematopoietic differentiation Mxd4 is an important player in the regulation of blood progenitor proliferation, and downregulation of its expression might be required for a proliferative burst preceding lineage specification.
Mxd4 and Mnt upregulation following OX40 (显示 TNFRSF4 抗体) engagement most likely increases T-cell survival
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
, class C basic helix-loop-helix protein 12
, max dimerization protein 4
, max dimerizer 4
, max-associated protein 4
, max-interacting transcriptional repressor MAD4
, MAX dimerization protein 4
, basic helix-loop-helix transcription factor XMad4-236
, putative basic helix-loop-helix transcription factor variant 3