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MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. 再加上，我们可以发MAD2L1 抗体 (136)和数多这个蛋白质的别的产品。
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MiR (显示 MLXIP 蛋白)-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma by suppressing MAD2L1 expression.
Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.
TRAP1 (显示 TRAP1 蛋白) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (显示 TRAP1 蛋白)/TBP7 (显示 PSMC4 蛋白) quality control of CDK1 (显示 CDK1 蛋白) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.
Thes authors show that p31 (显示 ATP6V1E1 蛋白)(comet) binding to the TRIP13 (显示 TRIP13 蛋白) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (显示 TRIP13 蛋白) "pore loops", which then unfold MAD2 in the presence of ATP.
catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (显示 BUB3 蛋白) complex assembly
in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (显示 AURKB 蛋白).
Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (显示 BGN 蛋白)-DLBCL. Mad2 overexpression indicated a poor DFS (显示 FST 蛋白).
interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 (显示 CDC20 蛋白) inhibition.
we showed that BubR1 (显示 BUB1B 蛋白) and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity.
Studied the folding/unfolding process of the open and closed conformers of human Mad2.
Mad2 (显示 MXI1 蛋白)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
reduced MAD2 (显示 MXI1 蛋白) levels attenuate the apoptotic response to mis (显示 AMH 蛋白)-segregating sex chromosomes and allow the formation of aneuploid sperm.
p31comet-induced cell death is mediated by interactions with Mad2 (显示 MXI1 蛋白)
study shows that Mad2 (显示 MXI1 蛋白) is a novel substrate for CCP6 (显示 AGBL4 蛋白) in megakaryocytes; Mad2 (显示 MXI1 蛋白) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Exacerbating chromosome missegregation in CENP-E (显示 CENPE 蛋白)+/- mice by reducing levels of another mitotic checkpoint component (显示 BUB3 蛋白), Mad2 (显示 MXI1 蛋白), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Mad2 (显示 MXI1 蛋白) is also repressed by p53 (显示 TP53 蛋白) and its upregulation is required for chromosome instability in a p53 (显示 TP53 蛋白) mutant tumor model
Data show that Mad2 (显示 MXI1 蛋白) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (显示 APEX1 蛋白) inhibitor in vitro.
Pcid2 (显示 PCID2 蛋白) is essential for B cell survival through the regulation of MAD2 (显示 MXI1 蛋白) expression during B cell differentiation
tumours that experience transient Mad2 (显示 MXI1 蛋白) overexpression and consequent chromosome instability recur at markedly elevated rates
a functional Mad2 (显示 MXI1 蛋白)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
, MAD2-like protein 1
, mitotic arrest deficient 2-like protein 1
, mitotic arrest deficient, yeast, homolog-like 1
, mitotic spindle assembly checkpoint protein MAD2A
, MAD2 (mitotic arrest deficient, homolog)-like 1
, MAD2-like 1
, spindle assembly checkpoint protein Mad2
, MAD2 mitotic arrest deficient-like 1
, MAD2 mitotic arrest deficient-like 1 (yeast)