anti-Lysine (K)-Specific Demethylase 6B (Kdm6b) 抗体

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. 再加上,我们可以发Kdm6b 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
Kdm6b 216850 Q5NCY0
Kdm6b 23135 O15054
Kdm6b 363630  
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antibodies-online.cn销售最多的anti-Kdm6b 抗体

Showing 10 out of 94 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IF, IHC (p), WB Western blot analysis of anti-JMJD3 N-term Pab (ABIN387862) in Hela cell line lysates. JMJD3 N-term(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with JMJD3 N-term (ABIN387862), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10至11个工作日
$335.50
详细
Cow 非结合性 WB WB Suggested Anti-JMJD3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Lung 100 μL Log in to see 2至3个工作日
$319.00
详细
Cow 非结合性 WB WB Suggested Anti-JMJD3 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate Host:  Rabbit  Target Name:  JMJD3  Sample Type:  HepG2  Lane A:  Primary Antibody  Lane B:  Primary Antibody + Blocking Peptide  Primary Antibody Concentration:  2.5ug/mL  Peptide Concentration:  2.0ug/mL  Lysate Quantity:  25ug/lane  Gel Concentration:  6%-18% 100 μL Log in to see 2至3个工作日
$229.00
详细
非结合性 FACS, ICC, IF, WB Immunocytochemistry/Immunofluorescence: Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody [NBP1-06640] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-JMJD3 [NBP1-06640] at a 1:200 dilution overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Alpha tubulin (DM1A) [ABIN438547] was used as a co-stain at a 1:1000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective. 0.1 mL Log in to see 7至9个工作日
$514.63
详细
Bat 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 WB Western blot analysis of anti-JMJD3 Center Pab (ABIN387864) in Hela cell line lysates. JMJD3 Center(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10至11个工作日
$335.50
详细
Cow 非结合性 WB 100 μg Log in to see 7至9个工作日
$493.17
详细
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 WB Western blot analysis of anti-JMJD3 Center Pab (AP1022c) in Hela cell line lysates. 400 μL Log in to see 2至3个工作日
$515.63
详细
小鼠 非结合性 WB JMJD3/ KDM6B mAb (Clone 67-A2) tested by Western blot. JMJD3/ KDM6B detection by Western blot. The analysis was performed using cell lysate from BJ cells (lane 1) and BJ cells irradiated (lane 2). 100 μg Log in to see 1至2个工作日
$495.83
详细

引用最多的anti-Kdm6b 抗体

  1. Human Polyclonal Kdm6b Primary Antibody for IF, IHC (p) - ABIN387862 : Lu, Lu, Liao, Yu, Chung, Kao, Wu: Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 15 Pubmed References

  2. Human Polyclonal Kdm6b Primary Antibody for FACS, ICC - ABIN438547 : Pham, Yu, Walline, Muthukrishnan, Blum, Kaplan: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. in Journal of immunology (Baltimore, Md. : 1950) 2013 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal Kdm6b Primary Antibody for WB - ABIN387864 : Shaw, Martin: Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. in EMBO reports 2009 (PubMed)

更多抗Kdm6b的相互作用对抗体

Zebrafish Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. Data show that Spi1 (显示 SPI1 抗体) is a downstream target of histone demethylase (显示 MBD2 抗体) Jmjd3 (Jmjd3) during myelopoiesis.

  2. loss of both kdm6ba and kdm6bb shows Kdm6b proteins share redundant and pleiotropic roles in organogenesis without impacting initial cell fate specification.

  3. Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (显示 CAD 抗体) fin regeneration, and that Kdm6b.1 may be the histone demethylase (显示 MBD2 抗体) required during regeneration.

Mouse (Murine) Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. Our data show that chemical inhibition of the H3K27me3 demethylases Jmjd3/Utx (显示 KDM6A 抗体) blunts Neurogenin3 (显示 NEUROG3 抗体)-dependent gene activation in vitro. Conversely, inhibition of the H3K27me3 methyltransferase Ezh2 (显示 EZH2 抗体) enhances both the transactivation ability of Neurogenin3 (显示 NEUROG3 抗体) in cultured cells and the formation of insulin (显示 INS 抗体)-producing cells during directed differentiation from pluripotent cells

  2. Study indicates sequential chromatin events and identifies a crucial role for Jmjd3 in regulating the efficiency of the transition from Ngn3 (显示 NEUROG3 抗体)-low to Ngn3 (显示 NEUROG3 抗体)-high cells.

  3. When JMJD3 levels were decreased by RNA interference, the embryo development rate and quality were improved, but the knockdown of UTX (显示 KDM6A 抗体) produced the opposite results.

  4. binding of SMAD2 (显示 SMAD2 抗体)/3, the intracellular effectors of activin (显示 Actbeta 抗体) signaling, was significantly enriched at the Pmepa1 (显示 PMEPA1 抗体) gene, which encodes a negative feedback regulator of TGF-beta (显示 TGFB1 抗体) signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.

  5. Results identified Kdm6b as a novel regulator of the pro-fibrotic signature of peritoneal foam cells.

  6. These results suggest that the demethylase activity of Jmjd3, but not that of Utx, affects mouse axial patterning in concert with alterations in Hox gene expression.

  7. Direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop.

  8. Knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated osteoarthritis progression via inhibition of the anabolic metabolism of chondrocytes. The number of Kdm6b-positive chondrocytes was lower in osteoarthritis cartilage samples.

  9. Preliminary evidence suggests a role of JMJD3 in removal of H3K27me3 mark from promoters of hepatic transcription factors, thus activating epigenetically poised hepatic genes in bone marrow progenitor cells prior to partial nuclear reprogramming.

  10. Study provides evidence that miR (显示 MLXIP 抗体)-148a-3p reciprocally regulates adipocyte and osteoblast differentiation through directly targeting Kdm6b.

Human Lysine (K)-Specific Demethylase 6B (Kdm6b) interaction partners

  1. The KDM6B inhibitor GSK-J4 perturbed the PMA-mediated differentiation of THP-1 (显示 GLI2 抗体) cells. The AURKA (显示 AURKA 抗体) inhibitor alisertib accelerates the expression of the H3K27 demethylase (显示 MBD2 抗体) KDM6B, dissociating AURKA (显示 AURKA 抗体) and YY1 (显示 YY1 抗体) from the KDM6B promoter region and inducing differentiation.

  2. The interaction of methyltransferase EZH2 (显示 EZH2 抗体) or demethylase (显示 MBD2 抗体) JMJD3 on RGMA (显示 RGMA 抗体), RARb2, AR, PGR (显示 PGR 抗体), and ERa genes in the progression and aggressiveness of prostate cancer.

  3. We demonstrate that extraskeletal osteosarcoma (ESOS) may include at least two small subsets: an MDM2 (显示 MDM2 抗体)-amplified deep soft-tissue ESOS and an H3K27me3-deficient organ-based ESOS

  4. Our results demonstrate that in the early stage of sepsis, JMJD3 contributes to high levels of neutrophil mPR3 (显示 PRTN3 抗体) expression and thereby to the production of the inflammatory cytokine IL-1beta (显示 IL1B 抗体)

  5. Computational methods identifyied H3(17-33)-derived peptides with improved binding affinity that would allow co-crystallization with the KDM6B catalytic core. A co-crystallized H3(17-33)A21M peptide had interactions between the KDM6B zinc binding domain and the H3(17-23) region. KDM6B uses the zinc binding domain to achieve H3K27me3/me2 (显示 CELSR1 抗体) specificity. A 1564 His-to-Gln substitution explains its higher affinity than KDM6A (显示 KDM6A 抗体).

  6. Taken together, the authors propose that the miR (显示 MLXIP 抗体)-939-Jmjd3 axis perturbs the accessibility of hepatitis B virus enhancer II/core promoter (En II) promoter to essential nuclear factors (C/EBPalpha (显示 CEBPA 抗体) and SWI (显示 SMARCA1 抗体)/SNF (显示 SNRPA 抗体) complex) therefore leading to compromised viral RNA synthesis and hence restricted viral multiplication.

  7. These results demonstrated that histone demethylase (显示 MBD2 抗体) JMJD3 regulates CD11a (显示 ITGAL 抗体) expression in lupus T cells by affecting the H3K27me3 levels in the ITGAL (CD11a (显示 ITGAL 抗体)) promoter region, and JMJD3 might thereby serve as a potential therapeutic target for SLE.

  8. binding of SMAD2 (显示 SMAD2 抗体)/3, the intracellular effectors of activin (显示 Actbeta 抗体) signaling, was significantly enriched at the Pmepa1 (显示 PMEPA1 抗体) gene, which encodes a negative feedback regulator of TGF-beta (显示 TGFB1 抗体) signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.

  9. In this study, we showed that aberrantly upregulated JMJD3 exerts an anti-apoptotic effect in diffuse large B-cell lymphoma

  10. Our study therefore delineates KDM6B function that links NF-kappaB (显示 NFKB1 抗体) and MAPK (显示 MAPK1 抗体) signaling pathway mediating MM cell growth and survival, and validates KDM6B as a novel therapeutic target in MM.

Kdm6b 抗原简介

蛋白简介

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

Gene names and symbols associated with Kdm6b

  • lysine (K)-specific demethylase 6B (kdm6b) 抗体
  • lysine demethylase 6B (KDM6B) 抗体
  • lysine (K)-specific demethylase 6B, b (kdm6bb) 抗体
  • KDM1 lysine (K)-specific demethylase 6B (Kdm6b) 抗体
  • lysine demethylase 6B (Kdm6b) 抗体
  • 1700064E03Rik 抗体
  • BC038313 抗体
  • JMJD3 抗体
  • kdm6b 抗体
  • mKIAA0346 抗体
  • si:ch211-237l4.7 抗体

Protein level used designations for Kdm6b

jumonji domain containing 3 , lysine (K)-specific demethylase 6B , jumonji domain containing 3, histone lysine demethylase , lysine-specific demethylase 6B-like , jmjC domain-containing protein 3 , jumonji domain-containing protein 3 , lysine-specific demethylase 6B , lysine demethylase 6B , jumonji domain-containing 3

GENE ID SPECIES
779446 Xenopus (Silurana) tropicalis
468438 Pan troglodytes
563644 Danio rerio
716348 Macaca mulatta
100414637 Callithrix jacchus
100140276 Bos taurus
100343083 Oryctolagus cuniculus
216850 Mus musculus
23135 Homo sapiens
489481 Canis lupus familiaris
363630 Rattus norvegicus
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