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Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. 再加上，我们可以发Kdm6b 试剂盒 (2) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal Kdm6b Primary Antibody for IF, IHC (p) - ABIN387862
Lu, Lu, Liao, Yu, Chung, Kao, Wu: Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. in The Journal of biological chemistry 2010
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Human Polyclonal Kdm6b Primary Antibody for FACS, ICC - ABIN438547
Pham, Yu, Walline, Muthukrishnan, Blum, Kaplan: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. in Journal of immunology (Baltimore, Md. : 1950) 2013
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Human Polyclonal Kdm6b Primary Antibody for WB - ABIN387864
Shaw, Martin: Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. in EMBO reports 2009
Data show that Spi1 (显示 SPI1 抗体) is a downstream target of histone demethylase (显示 MBD2 抗体) Jmjd3 (Jmjd3) during myelopoiesis.
loss of both kdm6ba and kdm6bb shows Kdm6b proteins share redundant and pleiotropic roles in organogenesis without impacting initial cell fate specification.
Data demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal (显示 CAD 抗体) fin regeneration, and that Kdm6b.1 may be the histone demethylase (显示 MBD2 抗体) required during regeneration.
Our data show that chemical inhibition of the H3K27me3 demethylases Jmjd3/Utx (显示 KDM6A 抗体) blunts Neurogenin3 (显示 NEUROG3 抗体)-dependent gene activation in vitro. Conversely, inhibition of the H3K27me3 methyltransferase Ezh2 (显示 EZH2 抗体) enhances both the transactivation ability of Neurogenin3 (显示 NEUROG3 抗体) in cultured cells and the formation of insulin (显示 INS 抗体)-producing cells during directed differentiation from pluripotent cells
Study indicates sequential chromatin events and identifies a crucial role for Jmjd3 in regulating the efficiency of the transition from Ngn3 (显示 NEUROG3 抗体)-low to Ngn3 (显示 NEUROG3 抗体)-high cells.
When JMJD3 levels were decreased by RNA interference, the embryo development rate and quality were improved, but the knockdown of UTX (显示 KDM6A 抗体) produced the opposite results.
binding of SMAD2 (显示 SMAD2 抗体)/3, the intracellular effectors of activin (显示 Actbeta 抗体) signaling, was significantly enriched at the Pmepa1 (显示 PMEPA1 抗体) gene, which encodes a negative feedback regulator of TGF-beta (显示 TGFB1 抗体) signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.
Results identified Kdm6b as a novel regulator of the pro-fibrotic signature of peritoneal foam cells.
These results suggest that the demethylase (显示 MBD2 抗体) activity of Jmjd3, but not that of Utx (显示 KDM6A 抗体), affects mouse axial patterning in concert with alterations in Hox (显示 MSH2 抗体) gene expression.
Direct genetic and molecular evidence that JMJD3 is a key mediator for the kisspeptin-estrogen feedback loop.
Knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated osteoarthritis progression via inhibition of the anabolic metabolism of chondrocytes. The number of Kdm6b-positive chondrocytes was lower in osteoarthritis cartilage samples.
Preliminary evidence suggests a role of JMJD3 in removal of H3K27me3 mark from promoters of hepatic transcription factors, thus activating epigenetically poised hepatic genes in bone marrow progenitor cells prior to partial nuclear reprogramming.
Study provides evidence that miR (显示 MLXIP 抗体)-148a-3p reciprocally regulates adipocyte and osteoblast differentiation through directly targeting Kdm6b.
Computational methods identifyied H3(17-33)-derived peptides with improved binding affinity that would allow co-crystallization with the KDM6B catalytic core. A co-crystallized H3(17-33)A21M peptide had interactions between the KDM6B zinc binding domain and the H3(17-23) region. KDM6B uses the zinc binding domain to achieve H3K27me3/me2 (显示 CELSR1 抗体) specificity. A 1564 His-to-Gln substitution explains its higher affinity than KDM6A (显示 KDM6A 抗体).
Taken together, the authors propose that the miR (显示 MLXIP 抗体)-939-Jmjd3 axis perturbs the accessibility of hepatitis B virus enhancer II/core promoter (En II) promoter to essential nuclear factors (C/EBPalpha (显示 CEBPA 抗体) and SWI (显示 SMARCA1 抗体)/SNF (显示 SNRPA 抗体) complex) therefore leading to compromised viral RNA synthesis and hence restricted viral multiplication.
These results demonstrated that histone demethylase (显示 MBD2 抗体) JMJD3 regulates CD11a (显示 ITGAL 抗体) expression in lupus T cells by affecting the H3K27me3 levels in the ITGAL (CD11a (显示 ITGAL 抗体)) promoter region, and JMJD3 might thereby serve as a potential therapeutic target for SLE.
In this study, we showed that aberrantly upregulated JMJD3 exerts an anti-apoptotic effect in diffuse large B-cell lymphoma
Our study therefore delineates KDM6B function that links NF-kappaB (显示 NFKB1 抗体) and MAPK (显示 MAPK1 抗体) signaling pathway mediating MM cell growth and survival, and validates KDM6B as a novel therapeutic target in MM.
Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 (显示 STAT6 抗体) target gene CCL18 (显示 CCL18 抗体), while induction of other STAT6 (显示 STAT6 抗体)-inducible genes such as SPINT2 (显示 SPINT2 抗体) remained unaffected by JMJD3.
Here, we discuss the roles of lysine 27 demethylases, JMJD3 and UTX (显示 KDM6A 抗体), in cancer and potential therapeutic avenues targeting these enzymes. Despite a high degree of sequence similarity in the catalytic domain between JMJD3 and UTX (显示 KDM6A 抗体), numerous studies revealed surprisingly contrasting roles in cellular reprogramming and cancer, particularly leukemia
inhibition of the H3K27 demethylase (显示 MBD2 抗体) JMJD3 in naive CD4 (显示 CD4 抗体) T cells demonstrates how critically important molecules required for T cell differentiation, such as JAK2 (显示 JAK2 抗体) and IL12RB2 (显示 IL12RB2 抗体), are regulated by H3K27me3.
KDM6B expression strongly correlates with ERbeta (显示 ESR2 抗体) level in human pleural mesothelioma tumors and cell lines.
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
jumonji domain containing 3
, lysine (K)-specific demethylase 6B
, jumonji domain containing 3, histone lysine demethylase
, lysine-specific demethylase 6B-like
, jmjC domain-containing protein 3
, jumonji domain-containing protein 3
, lysine-specific demethylase 6B
, lysine demethylase 6B
, jumonji domain-containing 3