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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. 再加上，我们可以发LCP1 试剂盒 (10) 和 LCP1 蛋白 (6)和数多这个蛋白质的别的产品。
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Cytomegalovirus (CMV) Polyclonal LCP1 Primary Antibody for BP, ELISA - ABIN1586192
Flinsenberg, Compeer, Koning, Klein, Amelung, van Baarle, Boelens, Boes: Fc? receptor antigen targeting potentiates cross-presentation by human blood and lymphoid tissue BDCA-3+ dendritic cells. in Blood 2012
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Human Polyclonal LCP1 Primary Antibody for ICC, IF - ABIN4346103
Bachmann, Burté, Pramana, Conte, Brown, Orimadegun, Ajetunmobi, Afolabi, Akinkunmi, Omokhodion, Akinbami, Shokunbi, Kampf, Pawitan, Uhlén, Sodeinde, Schwenk, Wahlgren, Fernandez-Reyes, Nilsson: Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. in PLoS pathogens 2014
the actin-bundling protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages.
Results identify L-plastin as a key effector of Mst1 (显示 MST1 抗体) and establish a novel mechanism linking a signaling intermediate to an actin-binding protein (显示 PFN1 抗体) critical to T cell migration.
L-plastin modulates both T- and B-cell function during the germinal center reaction and the production of T-cell-dependent antibody responses.
L-plastin may participate in signaling that enables lymphocyte transmigration
LPL-dependent actin bundling facilitates the formation of lamellipodia and normal immunological synapses and thereby enables T cell activation.
Regulation of sealing ring formation by L-plastin and cortactin (显示 CTTN 抗体) in osteoclasts.
We thus identify L-plastin as a molecule critical for CCR7 (显示 CCR7 抗体)-mediated t-cell motility but dispensable for early CCR7 (显示 CCR7 抗体) signaling.
AngII-dependent phosphorylation of LCP1 in cultured podocytes was mediated by the kinases ERK (显示 EPHB2 抗体), p90 (显示 CANX 抗体) ribosomal S6 kinase (显示 RPS6KB1 抗体), PKA, or PKC (显示 PRRT2 抗体). LCP1 phosphorylation increased filopodia formation.
L-plastin regulates the stability of the immune synapse of naive and effector T-cells. (Review)
The findings support a mechanism in which miR (显示 MLXIP 抗体)-375 suppresses RUNX1 (显示 RUNX1 抗体) levels, resulting in reduced vimentin (显示 VIM 抗体) and L-plastin expression. Knockdown of RUNX1 (显示 RUNX1 抗体), L-plastin, and vimentin (显示 VIM 抗体) resulted in significant reductions in cell invasion in vitro, indicating the functional significance of miR (显示 MLXIP 抗体)-375 regulation of specific proteins involved in head and neck squamous cell carcinoma (HNSCC) invasion.
In this study, the authors found that the actin filament bundling abilities of PLS1 (显示 PLS1 抗体) and PLS2 were similarly sensitive to Ca(2 (显示 CA2 抗体)+) (pCa50 ~6.4), whereas PLS3 (显示 PLS3 抗体) was less sensitive (pCa50 ~5.9).
elevated L-plastin expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin than fascin (显示 FSCN1 抗体) levels.
Enhanced nitroxidative stress may results in LPL S-glutathionylation leading to impaired chemotaxis, polarization, and bactericidal activity of human neutrophils.
association of SNPs in LCP1 and CTIF (显示 KIAA0427 抗体) with hearing
An NKX3.1 (显示 NKX3-1 抗体) binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer
The proteins (HSP90b (显示 HSP90AB1 抗体), TSM1 and L-plastin) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.
Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 (显示 PLS3 抗体) and LCP1 could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets.
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
, leucocyte-specific plastin 1
, 65 kDa macrophage protein
, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65)
, plastin 2, L
, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)
, Lymphocyte cytosolic protein-1 (plasmin)
, bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))
, plastin 2
, epidermal Langerhans cell protein LCP1