Leupaxin 蛋白 (LPXN)

The product encoded by LPXN is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. 再加上,我们可以发Leupaxin 抗体 (60)Leupaxin 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
LPXN 9404 O60711
LPXN 107321 Q99N69
大鼠 LPXN LPXN 293783  
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antibodies-online.cn销售最多的Leupaxin 蛋白

Showing 7 out of 8 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
详细
大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至18个工作日
$560.00
详细
大肠杆菌(E. Coli) 小鼠 非结合性 SDS-PAGE analysis of Mouse LPXN Protein. 100 μg Log in to see 11至18个工作日
$611.18
详细
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$414.29
详细
大肠杆菌(E. Coli) 非结合性 SDS-PAGE analysis of Human LPXN Protein. 100 μg Log in to see 11至18个工作日
$540.11
详细
酵母菌 His tag   1 mg Log in to see 60至71个工作日
$3,063.50
详细

LPXN 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
,
Mouse (Murine) ,
,

更多Leupaxin (LPXN)互动伙伴

Human Leupaxin (LPXN) interaction partners

  1. LPXN may facilitate bladder cancer progression by upregulating the expression of S100P (显示 S100P 蛋白) via PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) pathway. These results provide a novel insight into the role of LPXN in tumorigenesis and progression of bladder cancer and potential therapeutic target of bladder cancer.

  2. this is the first demonstration of a role for the leupaxin in the regulation of hepatocellular carcinoma progression, at least in part, by enhancing beta-catenin (显示 CTNNB1 蛋白) transcription activity.

  3. The full-length leupaxin binds to the Pyk2 (显示 PTK2B 蛋白)-focal adhesion targeting domain.

  4. Authors demonstrate that LPXN directly influences cytoskeletal dynamics via interaction with the actin-binding protein (显示 KPTN 蛋白) CaD and regulates CaD phosphorylation by recruiting ERK (显示 EPHB2 蛋白) to highly dynamic structures within PCa (显示 FLVCR1 蛋白) cells.

  5. Results show that leupaxin has particular influence on the progression and invasion of breast cancer cells and may therefore represent an interesting candidate protein for diagnosis and therapeutic interventions.

  6. first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors

  7. leupaxin functions as a paxillin (显示 PXN 蛋白) counterpart that potently suppresses the tyrosine phosphorylation of paxillin (显示 PXN 蛋白) during integrin signaling.

  8. leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex

  9. Leupaxin binding to tyrosine phosphatase PEP suggests that leupaxin may function as a signal-transducing complex with PEP.

  10. These data demonstrate that LPXN forms a signaling complex with Pyk2 (显示 PTK2B 蛋白), c-Src (显示 SRC 蛋白), and PTP-PEST (显示 PTPN12 蛋白) to regulate migration of prostate cancer cells.

Mouse (Murine) Leupaxin (LPXN) interaction partners

  1. leupaxin functions as a paxillin (显示 PXN 蛋白) counterpart that potently suppresses the tyrosine phosphorylation of paxillin (显示 PXN 蛋白) during integrin signaling.

  2. leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex

  3. Association of the scaffold protein (显示 HOMER1 蛋白) LPXN with Src (显示 SRC 蛋白) adds further complexity to the organization of the podosomal signaling complex in osteoclasts.

  4. Leupaxin plays an inhibitory role in BCR (显示 BCR 蛋白) signaling and B cell function.

  5. Leupaxin is enriched in mouse vascular smooth muscle and its expression is dynamically regulated during development.

蛋白简介Leupaxin (LPXN)

蛋白简介

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with Leupaxin 蛋白 (LPXN)

  • leupaxin (LPXN)
  • leupaxin (Lpxn)
  • leupaxin (lpxn)
  • leupaxin (PAAG_03110)
  • hypothetical protein (PGTG_11441)
  • Leupaxin (lpxn)
  • 4933402K05Rik 蛋白
  • A530083L21Rik 蛋白
  • AV278559 蛋白
  • LDPL 蛋白
  • MGC140379 蛋白

Protein level used designations for Leupaxin 蛋白 (LPXN)

leupaxin , Leupaxin

GENE ID SPECIES
9404 Homo sapiens
107321 Mus musculus
293783 Rattus norvegicus
423129 Gallus gallus
451205 Pan troglodytes
483465 Canis lupus familiaris
513264 Bos taurus
560743 Danio rerio
702033 Macaca mulatta
9097993 Paracoccidioides sp. 'lutzii' Pb01
10527262 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100008712 Oryctolagus cuniculus
100066577 Equus caballus
100196515 Salmo salar
100394284 Callithrix jacchus
100445873 Pongo abelii
100592030 Nomascus leucogenys
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