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The product encoded by LPXN is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. 再加上，我们可以发Leupaxin 抗体 (61) 和 Leupaxin 试剂盒 (4)和数多这个蛋白质的别的产品。
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LPXN may facilitate bladder cancer progression by upregulating the expression of S100P (显示 S100P 蛋白) via PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) pathway. These results provide a novel insight into the role of LPXN in tumorigenesis and progression of bladder cancer and potential therapeutic target of bladder cancer.
this is the first demonstration of a role for the leupaxin in the regulation of hepatocellular carcinoma progression, at least in part, by enhancing beta-catenin (显示 CTNNB1 蛋白) transcription activity.
The full-length leupaxin binds to the Pyk2 (显示 PTK2B 蛋白)-focal adhesion targeting domain.
Authors demonstrate that LPXN directly influences cytoskeletal dynamics via interaction with the actin-binding protein (显示 KPTN 蛋白) CaD and regulates CaD phosphorylation by recruiting ERK (显示 EPHB2 蛋白) to highly dynamic structures within PCa (显示 FLVCR1 蛋白) cells.
Results show that leupaxin has particular influence on the progression and invasion of breast cancer cells and may therefore represent an interesting candidate protein for diagnosis and therapeutic interventions.
first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors
leupaxin functions as a paxillin (显示 PXN 蛋白) counterpart that potently suppresses the tyrosine phosphorylation of paxillin (显示 PXN 蛋白) during integrin signaling.
leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex
Leupaxin binding to tyrosine phosphatase PEP suggests that leupaxin may function as a signal-transducing complex with PEP.
These data demonstrate that LPXN forms a signaling complex with Pyk2 (显示 PTK2B 蛋白), c-Src (显示 SRC 蛋白), and PTP-PEST (显示 PTPN12 蛋白) to regulate migration of prostate cancer cells.
Association of the scaffold protein (显示 HOMER1 蛋白) LPXN with Src (显示 SRC 蛋白) adds further complexity to the organization of the podosomal signaling complex in osteoclasts.
Leupaxin plays an inhibitory role in BCR (显示 BCR 蛋白) signaling and B cell function.
Leupaxin is enriched in mouse vascular smooth muscle and its expression is dynamically regulated during development.
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.