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May act as receptor for class I MHC antigens.
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Human Monoclonal LILRB3 Primary Antibody for CyTOF, FACS - ABIN4899820
Pfistershammer, Lawitschka, Klauser, Leitner, Weigl, Heemskerk, Pickl, Majdic, Böhmig, Fischer, Greinix, Steinberger: Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients. in Blood 2009
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Mouse (Murine) Monoclonal LILRB3 Primary Antibody for CyTOF, FACS - ABIN4899844
Thams, Brodin, Plantman, Saxelin, Kärre, Cullheim: Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
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Mouse (Murine) Monoclonal LILRB3 Primary Antibody for FACS - ABIN4896799
Zheng, Umikawa, Cui, Li, Chen, Zhang, Huynh, Hyunh, Kang, Silvany, Wan, Ye, Cantó, Chen, Wang, Ward, Zhang: Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. in Nature 2012
RPS9 (显示 RPS9 抗体)/LILRB3 (rs11666543) was associated with Takayasu arteritis.
Blockade of LILRB1 (显示 LILRB1 抗体) and LILRB3 receptors by monoclonal antibodies or short interfering RNA (siRNA) abrogated the specific antigen-presenting properties of dendritic cells, implying an important regulatory role of these molecules.
Coligation of LIR3 to LIR7 (显示 LILRA2 抗体) or to FcepsilonRI (显示 FCER1G 抗体) by means of a second monoclonal antibody significantly inhibited net histamine release, cysLT production, and IL-4 (显示 IL4 抗体) generation. LIR3 is counter-regulatory for both adaptive and innate receptors suggests.
Progenitor mast cells expressed cell surface inhibitory LILRB3. Mature cord-blood-derived mast cells had detectable mRNA encoding multiple LILRs, none were expressed on the cell surface.
LILRB3 is expressed on cultured osteoclast precursor cells derived from peripheral blood monocytes and plays a regulatory role in the development of osteoclasts.
Loss of gp91 is associated with Bone resorption.
Results imply a neuron-specific, cell-autonomous action of PirB on synaptic density in L2/3 pyramidal cells of visual cortex; suggest that PirB is needed to match spine density and excitatory synaptic function to activity levels within cortical circuits, thereby providing headroom for the cell to encode additional experiences at new synapses.
peripheral CD4 (显示 CD4 抗体)+ T cells from spontaneous murine arthritis model frequently express PIR-B
These results provide evidence for a critical role of the major histocompatibility complex class I/PirB signaling system in the generation of asymmetries in hippocampal circuitry.
These data identify paired Ig-like receptor B as a molecular checkpoint in IL-13 (显示 IL13 抗体)-induced eosinophil accumulation and activation
the overexpression of PirB inhibits the neuronal survival through increased neuron apoptosis
neural plasticity in adult visual cortex is actively repressed and can be enhanced by blocking PirB function.
The Nogo-B (显示 RTN4 抗体)-PirB axis controls macrophage-mediated vascular remodeling.
PIRB and LILRB2 (显示 LILRB2 抗体) were expressed in mouse and human platelets, respectively.
NogoA (显示 RTN4 抗体) receptors, NogoR1 and PirB, are expressed in the ventricular zone where neural stem cells reside.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
CD85 antigen-like family member A
, immunoglobulin-like transcript 5
, leukocyte immunoglobulin-like receptor 3
, leukocyte immunoglobulin-like receptor subfamily B member 3
, leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
, monocyte inhibitory receptor HL9
, cell-surface glycoprotein p91
, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
, paired immunoglobulin-like receptor B
, paired-Ig-like receptor B
, type 1 one-pass transmembrane Ig-like receptor