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Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).. 再加上，我们可以发Lrig1 蛋白 (11) 和 Lrig1 试剂盒 (1)和数多这个蛋白质的别的产品。
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Mouse (Murine) Polyclonal Lrig1 Primary Antibody for CyTOF, FACS - ABIN4900308
Jensen, Driskell, Watt: Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis. in Nature protocols 2010
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Mouse (Murine) Polyclonal Lrig1 Primary Antibody for WB - ABIN1881506
Ye, Gao, Xu, Zeng, Ou, Mao, Wang, He, Wang, Yang, Guo, Lei: Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity. in Journal of neuro-oncology 2009
Show all 2 Pubmed References
Mouse (Murine) Polyclonal Lrig1 Primary Antibody for FACS - ABIN4897517
Wong, Stange, Page, Buczacki, Wabik, Itami, van de Wetering, Poulsom, Wright, Trotter, Watt, Winton, Clevers, Jensen: Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. in Nature cell biology 2012
Human Polyclonal Lrig1 Primary Antibody for CyTOF, FACS - ABIN4900286
Oh, Lee, Choi, Suh, Shim, Song, Kim, Lee, Oh, Jeong, Cheong, Song, Kim: USP8 modulates ubiquitination of LRIG1 for Met degradation. in Scientific reports 2014
MiR (显示 MLXIP 抗体)-183 overexpression promoted radioresistance of glioblastoma via down-regulating LRIG1 and increasing the activity of EFGR (显示 EGFR 抗体)/Akt (显示 AKT1 抗体).
LRIG1 is a negative regulator of RET2A and RET2B and is also downregulated in papillary and medullary thyroid carcinoma
LRIG1 expression in human GC tissues is inversely correlated with miR (显示 MLXIP 抗体)-20a and EGFR (显示 EGFR 抗体).
Role of LRIG1 in cancer [review]
LRIG1 expression may represent a barrier to EMT (显示 ITK 抗体)
LRIG1 role in the atrophic epidermis
Downregulation of LRIG1 expression in oral verrucous carcinoma tissue is reported.
LRIG1, as a negative mediated gene of tumor, can inhibit biological function of PAs (显示 PASK 抗体) via inhibiting PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) and Ras/Raf (显示 RAF1 抗体)/ERK (显示 EPHB2 抗体) pathways, and it might be a new target for gene therapy ofPituitary adenomas
LRIG1 and Fascin-1 (显示 FSCN1 抗体) were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients.
Results suggest that the LRIG1could negatively control MRP-1 (显示 MDM4 抗体) and the apoptosis to improve the sensitivity of VP16-related chemotherapy.
Lrig1 marks gastric corpus epithelial progenitor cells capable of repopulating the damaged oxyntic mucosa by differentiating into normal gastric lineage cells in mouse stomach.
findings reveal a novel and essential role of Lrig1 in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB (显示 NTRK2 抗体) with Lrig1 represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF (显示 BDNF 抗体) during brain development
LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin
a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin (显示 AREG 抗体) and Egfr (显示 EGFR 抗体) activity.
LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice.
Loss of one Apc (显示 APC 抗体) allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis.
At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia.
LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3 (显示 STAT3 抗体).
A review summarizes the data that LRIG1 is a ERBB (显示 EGFR 抗体) negative regulator and tumour suppressor.
Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation (By similarity).
leucine-rich repeat protein LRIG1
, leucine-rich repeats and immunoglobulin-like domains protein 1
, ortholog of mouse integral membrane glycoprotein LIG-1
, integral membrane glycoprotein