Leucine-Rich PPR-Motif Containing 蛋白 (LRPPRC)

LRPPRC encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). 再加上,我们可以发LRPPRC 抗体 (48)LRPPRC 试剂盒 (10)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
LRPPRC 10128 P42704
大鼠 LRPPRC LRPPRC 313867 Q5SGE0
LRPPRC 72416 Q6PB66
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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LRPPRC 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine)

更多Leucine-Rich PPR-Motif Containing (LRPPRC)互动伙伴

Human Leucine-Rich PPR-Motif Containing (LRPPRC) interaction partners

  1. Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation.

  2. To investigate the impact of the OXPHOS defect in the liver, aothors analyzed the mitochondrial phenotype in mice harboring an hepatocyte-specific inactivation of Lrpprc. Loss of LRPPRC in the liver caused a generalized growth delay, and typical histological features of mitochondrial hepatopathy.

  3. There were no significant correlations between LRP130, SIRT3, or PGC-1alpha mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130, SIRT3, and PGC-1alpha were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle.

  4. LRPPRC displays a broad and strong RNA binding capacity in vitro in contrast to SLIRP that associates only weakly with RNA.

  5. High expression of ULK1 (显示 ULK1 蛋白) concomitant with high expression of LRPPRC may serve as useful markers for shorter biochemical progression (BCP (显示 OPN1SW 蛋白))-free survival and overall survival in patients with metastatic prostate cancer (PCa (显示 FLVCR1 蛋白)) after androgen deprivation therapy (ADT).

  6. This is the first study to report hypermethylation of LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue

  7. LRPPRC knock-down in mammalian cells leads to an imbalance between mitochondria-encoded and nuclear-encoded subunits of complex IV

  8. study identifies LRPPRC as an important disease-causing gene in an early-onset, multisystem and neurological mitochondrial disease.

  9. LRPPRC levels were reduced in muscle cells and undetectable in liver from French Canadian Leigh Syndrome patients.

  10. LRPPRC is a transcription factor related to ABCB1 expression and highlight the importance of epigenetic regulation in CML resistance.

Mouse (Murine) Leucine-Rich PPR-Motif Containing (LRPPRC) interaction partners

  1. Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation.

  2. Data suggest NT-Pgc-1alpha (alternative splicing isoform of nuclear protein Pgc-1alpha) is located in mitochondrial matrix in brown adipocytes, specifically enriched at D-loop region of mitochondrial DNA at promoter region of Lrpprc (leucine-rich PPR-motif containing protein); expression of NT-Pgc-1alpha (rather than Pgc-1alpha) in brown adipocytes appears to induce expression of electron transport chain complex proteins.

  3. both LRPPRC and SLIRP are required for maintaining mt-mRNA steady-state levels independent of their roles in stabilizing the other partner of the LRPPRC-SLIRP complex.

  4. Ectopic expression of LRPPRC in the mouse liver completely interdicted non-alcoholic fatty liver disease, including inflammation.

  5. LRPPRC deficiency in Leigh syndrome causes an ATP synthase deficiency.

  6. LRPPRC does not directly regulate mtDNA transcription but rather acts as a post-transcriptional regulator of mammalian mtDNA expression.

  7. Heart-specific Lrpprc disruption causes mitochondrial cardiomyopathy with drastic reduction in steady-state mitochondrial mRNA levels. LRPPRC forms an RNA-dependent protein complex needed to maintain a mitochondrial pool of non-translated mRNAs.

  8. These data strongly suggest that LRPPRC is involved in the maturation of cytochrome c (显示 CYCS 蛋白) oxidase (COX (显示 CPOX 蛋白)), and is involved in stabilizing of mitochondrial mRNAs encoding COX (显示 CPOX 蛋白) transcripts.

  9. LRP130 protein remodels mitochondria and stimulates fatty acid oxidation.

  10. Our results demonstrate that LIF (显示 LIF 蛋白) signaling via the gp130/JAK (显示 JAK3 蛋白)/STAT3 (显示 STAT3 蛋白) pathway is required for the initiation of the astrogliosis-like reaction of retinal Muller cells after optic nerve injury.

蛋白简介LRPPRC

蛋白简介

This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome.

Gene names and symbols associated with LRPPRC

  • leucine rich pentatricopeptide repeat containing (LRPPRC)
  • leucine-rich pentatricopeptide repeat containing (Lrpprc)
  • leucine-rich PPR-motif containing (Lrpprc)
  • 3110001K13Rik 蛋白
  • C76645 蛋白
  • CLONE-23970 蛋白
  • Gp130 蛋白
  • Lrp130 蛋白
  • Lrp157 蛋白
  • Lsfc 蛋白

Protein level used designations for LRPPRC

130 kDa leucine-rich protein , LRP 130 , leucine-rich PPR motif-containing protein, mitochondrial , leucine-rich PPR-motif containing , mitochondrial leucine-rich PPR motif-containing protein , leucine rich protein 157 , leucine-rich protein 157 , rLRP157 , leucine rich protein LRP130

GENE ID SPECIES
10128 Homo sapiens
313867 Rattus norvegicus
72416 Mus musculus
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