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Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. 再加上，我们可以发Leucine Rich Repeat and Fibronectin Type III Domain Containing 5 抗体 (18)和数多这个蛋白质的别的产品。
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Presynaptic differentiation induced by protein tyrosine phosphatase receptor type D (显示 PTPRD 蛋白) (PTPdelta)-leucine rich repeat and fibronectin type III domain containing 5 (SALM5) requires the dimeric property of SALM5.
In the 2:2 heterotetrameric SALM5/PTPdelta complex, a SALM5 dimer bridges two separate PTPdelta molecules.
SALM5/Lrfn5, has recently been implicated in severe progressive autism and familial schizophrenia, pointing to the clinical importance of SALMs.[review]
Expression of SALM family proteins SALM3 (显示 LRFN4 蛋白) and SALM5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons.
These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR (显示 PTPRF 蛋白)-RPTPs (显示 PTPRS 蛋白) and is important for the regulation of excitatory synaptic strength.
we identified herpes virus entry mediator (显示 TNFRSF14 蛋白) as a functional receptor that mediates SALM5's suppressive function. Our findings reveal a molecular link between the neuronal system and the immune system, and provide potential therapeutic targets for the control of CNS diseases.
Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).
fibronectin type III, immunoglobulin and leucine rich repeat domains 8
, leucine-rich repeat and fibronectin type-III domain-containing protein 5