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May function as an activator of the canonical Wnt signaling pathway upstream of ctnnb1/beta-catenin.
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Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.
FATylation of LRRFIP2 occurs on two distinct sites, each being modified by a single FAT10 (显示 UBD 蛋白) moiety.
A novel exonic rearrangement affecting MLH1 (显示 MLH1 蛋白) and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families
Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4 (显示 TLR4 蛋白))-mediated signaling.
These data suggest that LRRFIP2 plays an important role in transducing Wnt (显示 WNT2 蛋白) signals.
LRR-binding MyD88 (显示 MYD88 蛋白) interactor LRRFIP2 is a positive regulator of NF-kappa B (显示 NFKB1 蛋白) activity and is also a positive regulator of cytokine production in lipopolysaccharide-stimulated macrophages, suggesting a functional role in TLR4 (显示 TLR4 蛋白)-mediated inflammatory response.
LRRFIP2 inhibits NLRP3 (显示 NLRP3 蛋白) inflammasome activation by recruiting the caspase-1 (显示 CASP1 蛋白) inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 (显示 NLRP3 蛋白) inflammasome.
May function as an activator of the canonical Wnt signaling pathway upstream of ctnnb1/beta-catenin. May be required for dorsal axis formation (By similarity).
LRR FLII-interacting protein 2
, leucine-rich repeat flightless-interacting protein 2
, leucine rich repeat (in FLII) interacting protein 2
, leucine-rich repeat flightless-interacting protein 2-like