Lectin, Mannose-Binding, 1 蛋白 (LMAN1)

The protein encoded by LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. 再加上,我们可以发LMAN1 抗体 (51)LMAN1 试剂盒 (8)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
LMAN1 3998 P49257
LMAN1 70361 Q9D0F3
大鼠 LMAN1 LMAN1 116666 Q62902
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,370.21
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
$7,493.38
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
$5,262.31
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,370.21
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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大肠杆菌(E. Coli) 非结合性 SDS-PAGE analysis of Human LMAN1 Protein. 100 μg Log in to see 11至18个工作日
$653.82
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LMAN1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,
Mouse (Murine) ,
,

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Human Lectin, Mannose-Binding, 1 (LMAN1) interaction partners

  1. Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2

  2. Genetic variants in the exon1 of MBL gene per se are not risk factors for Systemic lupus erythematosus (SLE) in South Indian Tamils. However, the association of codon 54 (rs1800450) with medium vessel vasculitis suggests that it may be a genetic modifier of clinical phenotype in SLE.

  3. Mannan-binding lectin reduces CpG DNA-induced inflammatory cytokine production in monocytes.

  4. MMP-9 secretion was reduced in the LMAN1 knockout cell line compared to control cells confirming the functional role of LMAN1.

  5. Authors identified a class of pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their association with ERGIC-53, and a role for ERGIC-53 in the propagation of several highly pathogenic RNA virus families.

  6. Studies indicate that the LMAN1-CRD contains distinct, separable binding sites for both its partner protein MCFD2 and the cargo proteins FV/FVIII.

  7. Data indicate that together with its soluble coreceptor MCFD2, LMAN1 transports coagulation factors V (FV) and VIII (FVIII).

  8. Mutations in LMAN1 lead to F5F8D (combined deficiency of factor V And factor VIII) due to alterations in LMAN1-MCFD2 complex of coat protein (COP)II complex trafficking machinery; 70% of F5F8D patients have mutations in LMAN1. [REVIEW]

  9. UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53.

  10. Two new mutations at ERGIC-53 gene in a Turkish family.

  11. Data present the crystal structure of the LMAN1/MCFD2 complex and relate it to patient mutations. Circular dichroism data show that the majority of the substitution mutations give rise to a disordered or severely destabilized MCFD2 protein.

  12. Data show that mutations in MCFD2 that disrupt the tertiary structure and abolish LMAN1 binding still retain the FV/FVIII binding activities, suggesting that this interaction is independent of Ca(2+)-induced folding of the protein.

  13. Among Papua New Guinea malaria patients, 2 new mannose-binding lectin polymorphic promoter sites were found: one in the untranslated region at position +1 (G-->A, termed R/S), and the 2nd upstream of the gene at position -4 (G-->A, termed T/U).

  14. MBL deficiency is not a risk factor for SLE in women from the Canary Islands, but it is associated with lower prevalence of autoantibodies and with later age at disease onset and at SLE diagnosis.

  15. inactivating mutations in MCFD2 cause combined deficiency of factor V and factor VIII with a phenotype indistinguishable from that caused by mutations in LMAN1

  16. Data show that the mRNA of lectin ERGIC-53 and its related protein VIP36 is induced by the known inducers of endoplasmic reticulum stress, tunicamycin and thapsigargin.

  17. an interaction between LMAN1 and FVIII in vivo was mediated via high mannose-containing asparagine-linked oligosaccharides that are densely situated within the B domain of FVIII, as well as protein-protein interactions

  18. Results describe the x-ray structure of human mannan-binding lectin-associated protein 19 (MAp19), and identify the residues involved in the interaction of MAp19 with mannan-binding lectin and L-ficolin.

  19. surfactant proteins A and D and mannose-binding lectin play roles in inflammation caused by DNA in lungs and other tissues

  20. ERGIC-53 and MCFD2 have important functions during cellular response to stress conditions

Mouse (Murine) Lectin, Mannose-Binding, 1 (LMAN1) interaction partners

  1. MCFD2-deficient mice generated by gene targeting also demonstrate reduced plasma FV and FVIII, with levels lower than those in LMAN1-deficient mice, similar to previous observations in LMAN1- and MCDF2-deficient humans.

  2. LMAN1 may play a role in photoreceptor gene transport and homeostasis.

  3. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin.

  4. surfactant proteins A and D and mannose-binding lectin play roles in inflammation caused by DNA in lungs and other tissues

  5. These results indicate that increased levels of cargo receptor proteins might have a function either in the quality control of protein folding in the endoplasmic reticulum or in the homeostasis of the intermediate compartment and Golgi complex.

  6. ERGIC-53 gene transcription is regulated in response to endoplasmic reticulum stress

蛋白简介LMAN1

蛋白简介

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

Gene names and symbols associated with LMAN1

  • lectin, mannose binding 1 (LMAN1)
  • lectin, mannose-binding, 1 (Lman1)
  • complexin 3 (cplx3)
  • lectin, mannose-binding, 1 (lman1)
  • lectin, mannose binding 1 (lman1)
  • lectin, mannose binding 1 S homeolog (lman1.S)
  • lectin, mannose binding 1 (Lman1)
  • 2610020P13Rik 蛋白
  • AI326273 蛋白
  • AU043785 蛋白
  • C730041J05 蛋白
  • cpx-iii 蛋白
  • cpxiii 蛋白
  • ERGIC-53 蛋白
  • ERGIC53 蛋白
  • F5F8D 蛋白
  • FMFD1 蛋白
  • gp58 蛋白
  • lman1 蛋白
  • lman1-a 蛋白
  • MCFD1 蛋白
  • MR60 蛋白
  • p58 蛋白
  • wu:fc54c09 蛋白
  • wu:fi36e01 蛋白
  • Xp58 蛋白

Protein level used designations for LMAN1

ER-Golgi intermediate compartment 53 kDa protein , endoplasmic reticulum-golgi intermediate compartment protein 53 , intracellular mannose specific lectin , intracellular mannose-specific lectin MR60 , protein ERGIC-53 , lectin, mannose-binding, 1 , lectin mannose-binding 1 , fc54c09 , fi36e01 , protein ERGIC-53-like , ERGIC-53 protein , intracellular mannose specific lectin MR60 , LOW QUALITY PROTEIN: protein ERGIC-53

GENE ID SPECIES
3998 Homo sapiens
70361 Mus musculus
116666 Rattus norvegicus
426849 Gallus gallus
455448 Pan troglodytes
476186 Canis lupus familiaris
496634 Xenopus (Silurana) tropicalis
559775 Danio rerio
697449 Macaca mulatta
100021881 Monodelphis domestica
100354112 Oryctolagus cuniculus
100404326 Callithrix jacchus
100475249 Ailuropoda melanoleuca
100562643 Anolis carolinensis
100592766 Nomascus leucogenys
394295 Xenopus laevis
511649 Bos taurus
100728262 Cavia porcellus
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