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LHX3 encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. 再加上，我们可以发LHX3 试剂盒 (10) 和 LHX3 蛋白 (7)和数多这个蛋白质的别的产品。
Showing 10 out of 26 products:
investigated the specific mutations in PROP1 (显示 PROP1 抗体), POU1F1 (显示 POU1F1 抗体), LHX3, and HESX1 (显示 HESX1 抗体) genes in patients with combined pituitary hormone (显示 CGA 抗体) deficiency (CPHD) in Turkey
LHX3 is upregulated in high-grade oligodendroglioma.
The downstream enhancer region of LHX3 in regulating gene expression at the cellular level during development, is reported.
Data suggest that low serum FSH (显示 BRD2 抗体) (follicle stimulating hormone) levels in men with SNP in promoter region of FSHB (FSH beta (显示 FSHB 抗体) subunit (显示 POLG 抗体); -211G/T) result from reduced LHX3 binding to FSHB (显示 FSHB 抗体) promoter and down-regulation of FSHB (显示 FSHB 抗体) transcription in gonadotrophs.
The present study was unable to confirm a significant association of all of the three SNPs, rs12338076 in LHX3-QSOX2 (显示 QSOX2 抗体), and rs1457595 and rs17032362 in IGF1 (显示 IGF1 抗体), with adult height in our study population.
descriprion of pediatric patients with combined pituitary hormone (显示 CGA 抗体) deficiency with a novel mutation in LHX3; the T194R mutation affects a critical residue in the LHX3 protein; study extends understanding of phenotypic features, molecular mechanism and developmental course associated with mutations in the LHX3 gene
This study of the first nonconsanguineous patient with LHX3 mutations demonstrates the pleiotropic roles of LHX3 during development and its full involvement in the complex disease phenotype of syndromic combined pituitary hormone (显示 CGA 抗体) deficiency.
This study establishes ISL1 (显示 ISL1 抗体) as a novel transcriptional regulator of LHX3 and describes a potential mechanism for regulation by PITX1 (显示 PITX1 抗体).
LHX3 mutations are a rare cause of hypopituitarism. We report on a patient with a novel LHX3 mutation in exon 2 with the phenotype of combined pituitary hormone (显示 CGA 抗体) deficiency with short neck and sensorineural hearing impairment. [review]
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 (显示 QSOX2 抗体) and IGF1 (显示 IGF1 抗体) as adult height loci.
Lhx3 and Lhx4 (显示 LHX4 抗体) have roles in suppressing Kolmer-Agduhr interneuron characteristics within zebrafish axial motoneurons
LHX3 LIM homeodomain (显示 LHX2 抗体) transcription factor is involved in activation of the FSH beta (显示 FSHB 抗体)-subunit (显示 POLG 抗体) gene in the pituitary gonadotrope cell.
Association analysis indicated that the some SNPs studied are associated with the body weight at 6, 12 and 18months of age in Nanyang cattle (P<0.01 or P<0.05), providing evidence that some SNPs in LHX3 gene may be associated with body weight at certain ages.
The isolation and characterization of three polymorphisms of LHX3 are reported.
Results show that specific genomic loci associated with Islet-1 (Isl1 (显示 ISL1 抗体)) , LIM-homeobox 3 (Lhx3), and LMO4 (显示 LMO4 抗体) genes recruit the Isl1 (显示 ISL1 抗体)-Lhx3 complex to activate the transcription of Isl1 (显示 ISL1 抗体), Lhx3, and Lmo4 (显示 LMO4 抗体).
Together, the authors show the antagonistic regulation of the alpha-enhancer activity by Pax6 (显示 PAX6 抗体) and the LIM protein (显示 PDLIM1 抗体) complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.
conditional deletion of Shh (显示 SHH 抗体) in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3/Lhx4 (显示 LHX4 抗体) expression in RP epithelium.
Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1 (显示 ISL1 抗体)/Lhx3 in nascent motor neurons and Isl1 (显示 ISL1 抗体)/Onecut1 (显示 ONECUT1 抗体) in maturing hypaxial motor neurons.
All E1 sequences from lamprey to mouse responded equally well to Phox2a (显示 PHOX2A 抗体) and the Isl1 (显示 ISL1 抗体)-Lhx3 complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals
We discovered that expression of Cdkn1a (显示 CDKN1A 抗体) is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 (显示 LHX4 抗体) mutants.
Lhx3-LIM (显示 PDLIM5 抗体) domains play critical roles in transactivation of the Isl1 (显示 ISL1 抗体)-Lhx3 complex by not only directing the assembly of the Isl1 (显示 ISL1 抗体)-Lhx3 complex but also recruiting coactivators to the complex.
This treatment leads to activation of Lhx3 gene expression.
LHX3 interacts with inhibitor of histone acetyltransferase (显示 HAT 抗体) complex subunits LANP (显示 ANP32A 抗体) and TAF (显示 TAF8 抗体)-1beta to modulate pituitary gene regulation.
The results of this study suggested that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants.
lim homeobox 3
, LIM homeobox 3
, LIM homeobox protein 3
, LIM/homeobox protein Lhx3
, LIM/homeodomain protein LHX3
, homeobox protein LIM-3
, LIM homeodomain protein 3
, LIM homeodomain 3 protein b isoform
, LIM homeo box protein 3
, homeobox protein P-LIM