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LHX1 encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. 再加上，我们可以发LIM Homeobox 1 抗体 (74) 和 LIM Homeobox 1 蛋白 (9)和数多这个蛋白质的别的产品。
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Report novel missense mutation in LHX1 in congenital absence of the uterus and vagina which could change the transcriptional activity of LHX1 and its effect on the regulation of the downstream target gene GSC.
Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4 (显示 WNT4 ELISA试剂盒), HNF1B (显示 HNF1B ELISA试剂盒), and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%.
Data have identified TBX6 as a new gene associated with Mullerian aplasia. The results also support the relevance of LHX1 and CNVs in the development of this congenital malformation.
study concludes that heterozygous mutations of LHX1 might be one cause of the Mayer-Rokitansky-Kuster-Hauser syndrome in a subgroup of patients
Data indicate that expression of ERAS, LHX1, and CCRK (显示 CDK20 ELISA试剂盒) is increased in aggressive subgroups of medulloblastomas.
Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling
Mutations in the coding regions of LHX1 may not be a common genetic etiologic factor involved in Han Chinese patients with mullerian duct abnormalities.
Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity.
findings establish that the developmental marker Lim1 acts as an oncogene (显示 RAB1A ELISA试剂盒) in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma
Lim1 (also known as Lhx1) gene consists of a DNA-binding homeodomain and 2 cysteine-rich LIM (显示 PDLIM5 ELISA试剂盒) domains, which may participate in protein to protein interactions, and encodes a transcription factor.
Smad4 (显示 SMAD4 ELISA试剂盒)/Eomes (显示 EOMES ELISA试剂盒)-dependent Lhx1 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, and midline progenitors.
LHX1 is required in the anterior mesendoderm, but not in the mesoderm, for formation of the head.
Lhx1 maintains synchrony among circadian oscillator neurons of the suprachiasmatic nucleus.
Lhx1 is necessary for SCN (显示 SRI ELISA试剂盒) terminal differentiation, including expression of neuropeptides profoundly important for circadian function.
OTX2 (显示 OTX2 ELISA试剂盒) has a role in regulating Dkk1 (显示 DKK1 ELISA试剂盒) and Lhx1 activity in the anterior mesendoderm
These studies identify LHX1 as the first transcription factor that is essential in the Mullerian duct epithelial progenitor cells for female reproductive tract development.
a core regulatory subcircuit composed of Pax2/8, Gata3 (显示 GATA3 ELISA试剂盒) and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
Lhx1 therefore may influence the localization of primordial germ cells by modulating Ifitm1-mediated repulsive activity.
The response of LMC motor neurons to Reelin (显示 RELN ELISA试剂盒) is gated by Foxp1 (显示 FOXP1 ELISA试剂盒)- and Lhx1-mediated regulation of expression of the critical Reelin (显示 RELN ELISA试剂盒) signalling intermediate Dab1 (显示 DAB1 ELISA试剂盒).
Inactivation of either PINCH (显示 LIMS1 ELISA试剂盒) isoform independently leads to instability of ILK (显示 ILK ELISA试剂盒), loss of stretch-responsive anf (显示 HESX1 ELISA试剂盒) and vegf (显示 VEGFA ELISA试剂盒) expression, and progressive heart failure
These results demonstrate an essential role for Lhx1 in driving specification of the entire kidney field from the intermediate mesoderm.
nephrogenic transcription factors (osr1, osr2, hnf1b (显示 HNF1B ELISA试剂盒), lhx1, pax8 (显示 PAX8 ELISA试剂盒))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (显示 INHBA ELISA试剂盒), retinoic acid
Substantial evidence is found for a prosomeric organization of the diencephalon based on alternating expression of Lhx1/5 and Lhx2 (显示 LHX2 ELISA试剂盒)/9 genes during larval development and in the adult.
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract.
LIM homeobox protein 1
, LIM/homeobox protein Lhx1
, homeobox protein Lim-1
, LIM homeo box protein 1
, domesticus (clone 2.3 kB) lim-1
, Homeobox protein LMX-2
, Homeobox protein Lim-1