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There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. 再加上，我们可以发LIMK2 蛋白 (10) 和 LIMK2 试剂盒 (7)和数多这个蛋白质的别的产品。
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Human LIMK2 Primary Antibody for IHC - ABIN966486
Ohashi, Nagata, Maekawa, Ishizaki, Narumiya, Mizuno: Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. in The Journal of biological chemistry 2000
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Human Polyclonal LIMK2 Primary Antibody for IHC - ABIN966487
Soosairajah, Maiti, Wiggan, Sarmiere, Moussi, Sarcevic, Sampath, Bamburg, Bernard: Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. in The EMBO journal 2005
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Human Polyclonal LIMK2 Primary Antibody for ICC, IF - ABIN4330985
Kim, Ryu, Kim, Kang: LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission. in Cell death and differentiation 2014
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In turn, LIMK1 (显示 LIMK1 抗体) and LIMK2 are required for MT1-MMP (显示 MMP14 抗体)-dependent matrix degradation and cell invasion in a three-dimensional type I collagen environment.
High LIMK2 expression is associated with alcoholic hepatitis.
these results suggested that TUG1 mediates cell growth and chemoresistance of SCLC by regulating LIMK2b via EZH2 (显示 EZH2 抗体).
LIMK2 (rs149034313) is associated with Behcet's disease. The LIMK2 association is a missense variant with predicted protein damage that may influence functional interactions with proteins involved in cytoskeletal regulation by Rho GTPase (显示 RACGAP1 抗体), inflammation mediated by chemokine (显示 CCL1 抗体) and cytokine signaling pathways, T cell activation, and angiogenesis.
We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1 (显示 CFL1 抗体)) gene expressions in metabolic syndrome patients.
This study showed that LIMK2 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples.
Actin remodelling factor LIMK2 is a key player in the ciliogenesis control network in which YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) and directional vesicle trafficking are integral components.
Results show that in addition to a potential role in promoting metastasis, changes in LIMK1 (显示 LIMK1 抗体) and LIMK2 expression and/or activity might contribute to AR function in prostate cancer via regulation of microtubule cytoskeletal dynamics.
results highlight the exciting possibility of combining specific LIMK2 inhibitors with anticancer drugs in the treatment of multi-drug resistant cancers
LIMK2 expression was reduced in intestinal tumours of cancer-prone mice and in human colorectal cancer cell lines and tumours. LIMK2 expression progressively decreased with advancing stage of colorectal cancer.
These data suggest that osteoblasts can increase their mechanosensitivity under continuous mechanical stimulation by reducing the actin stress fiber formation through inhibiting the LIMK2 expression.
LIMK2 expression was reduced in intestinal tumours of cancer-prone mice.
LIMK2 activity is required for keratinocyte migration in the developing eyelid.
Using RNAi against LIMK2 to inhibit the cytoskeleton reorganization can promote the expression of c-fos gene and thus enhance the mechanosensitivity of c-fos gene in osteoblasts.
Results suggest that constitutive activation of the Rho-ROCK-LIM (显示 PDLIM5 抗体) kinase pathway by extracellular production of lysophosphatidic acid by the action of autotaxin (显示 ENPP2 抗体) is required to maintain the large size of lysosomes in visceral endoderm cells.
LIMK-1 (显示 LIMK1 抗体)/2 double knockout mice were more severely impaired in both ADF/cofilin (显示 CFL1 抗体) phosphorylation and excitatory synaptic function in the CA1 (显示 CA1 抗体) region of the hippocampus.
a novel pathway emanating from the TGF-beta type I receptor (显示 TGFBR1 抗体) and leading to regulation of actin assembly, via the kinase LIMK2.
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
, LIM domain kinase 2
, LIM domain kinase 2-like
, LIM motif-containing protein kinase 2
, LIM kinase 2
, LIM-containing protein kinase 2a
, LIM-containing protein kinase 2t
, Limk2t-1 and Limk2t-2