Ketohexokinase 蛋白 (KHK)

KHK encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. 再加上,我们可以发Ketohexokinase 抗体 (139)Ketohexokinase 试剂盒 (10)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
KHK 16548 P97328
大鼠 KHK KHK 25659 Q02974
KHK 3795 P50053
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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大肠杆菌(E. Coli) 非结合性 0.05 mg Log in to see 2至3个工作日
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大肠杆菌(E. Coli) 非结合性 Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 6至8个工作日
$322.14
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Mammalian Cells His tag   50 μg Log in to see 4 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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酵母菌 Orang-Utan His tag   1 mg Log in to see 60至71个工作日
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Human His tag   10 μg Log in to see 15至16个工作日
$212.50
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大肠杆菌(E. Coli) 非结合性   1 mg Log in to see 2至3个工作日
$2,546.15
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KHK 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , , , , ,
, ,

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Mouse (Murine) Ketohexokinase (KHK) interaction partners

  1. This studies provided the first evidence that fructokinase modulates vasopressin (显示 AVP 蛋白) synthesis in the SON and secretion from the posterior pituitary into circulation.

  2. Fructokinase knockout mice were protected from renal injury both at baseline and after high salt intake (3 wk) compared with wild-type mice. This was associated with higher levels of active (phosphorylated serine 1177) endothelial nitric oxide synthase (显示 NOS3 蛋白) in their kidneys.

  3. Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.

  4. Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5, probably by endogenous synthesis of fructose.

  5. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (显示 HIF1A 蛋白)) activation of SF3B1 (显示 SF3B1 蛋白) and SF3B1 (显示 SF3B1 蛋白)-mediated splice switching of KHK-A to KHK-C

  6. Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway.

  7. This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin (显示 INS 蛋白) resistance induced by high fructose, a widespread component of Western diets.

  8. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.

  9. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.

  10. Fructose-induced metabolic syndrome is prevented in mice lacking both fructokinase B and A but is exacerbated in mice lacking fructokinase A.

Human Ketohexokinase (KHK) interaction partners

  1. Data indicate metabolic enzymes NAD kinase (显示 NADK 蛋白) and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C (显示 INO80C 蛋白) as a tumor suppressor in KRAS(MUT (显示 MUT 蛋白)) colorectal tumor xenograft.

  2. Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C.

  3. compared with normal hepatocytes, hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc (显示 MYC 蛋白)-dependent and heterogeneous nuclear ribonucleoprotein (显示 PCBP2 蛋白) (hnRNP (显示 HNRNPC 蛋白)) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform.

  4. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (显示 HIF1A 蛋白)) activation of SF3B1 (显示 SF3B2 蛋白) and SF3B1 (显示 SF3B2 蛋白)-mediated splice switching of KHK-A to KHK-C

  5. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.

  6. This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 and SLC2A5 and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes.

  7. In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose.

  8. ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria.

  9. The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma (显示 MOK 蛋白)

  10. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.

蛋白简介Ketohexokinase (KHK)

蛋白简介

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Ketohexokinase 蛋白 (KHK)

  • ketohexokinase (KHK)
  • ketohexokinase (khk)
  • ketohexokinase (Hhal_0921)
  • ketohexokinase (AaeL_AAEL006316)
  • Ketohexokinase (Nwat_0240)
  • ketohexokinase (Khk)
  • KETHPRO 蛋白
  • khk 蛋白
  • wu:fj68h03 蛋白
  • zgc:92219 蛋白
  • zgc:92626 蛋白

Protein level used designations for Ketohexokinase 蛋白 (KHK)

ketohexokinase , Ketohexokinase , hepatic fructokinase

GENE ID SPECIES
100055449 Equus caballus
436909 Danio rerio
698328 Macaca mulatta
4710193 Halorhodospira halophila SL1
5567860 Aedes aegypti
9391692 Nitrosococcus watsonii C-113
100306748 Salmo salar
100351729 Oryctolagus cuniculus
16548 Mus musculus
25659 Rattus norvegicus
3795 Homo sapiens
100170647 Canis lupus familiaris
614868 Bos taurus
100447147 Pongo abelii
100523241 Sus scrofa
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