Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. 再加上，我们可以发Junctophilin 1 蛋白 (7) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal JPH1 Primary Antibody for ELISA, WB - ABIN527954
Vihola, Sirito, Bachinski, Raheem, Screen, Suominen, Krahe, Udd: Altered expression and splicing of Ca(2+) metabolism genes in myotonic dystrophies DM1 and DM2. in Neuropathology and applied neurobiology 2013
Human Polyclonal JPH1 Primary Antibody for ICC, IF - ABIN4327979
Boncompagni, Thomas, Lopez, Allen, Yuan, Kranias, Franzini-Armstrong, Perez: Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. in PLoS ONE 2012
Results show that JPH1 and GDAP1 share a common pathway and depend on each other; therefore, JPH1 can contribute to the phenotypical consequences of GDAP1 mutations.
This study suggests that genetic variants of JPH1 may modulate the effect of smoking on carotid plaque burden.
This study demonstrates that both JP1 and JP2 in skeletal muscle undergo Ca2+-dependent proteolysis by endogenous proteases when the intracellular Ca2+ is raised within the physiological range for a sustained period
JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery
Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction.
JP1 gene is expressed during the whole process of cardiogenesis, while JP1 protein only appears during the early stage.
an important fraction of resting plasmalemmal Ca(2+) permeability is mediated by the Orai1 pathway, which contributes to the control of [Ca(2+)](rest) and resting Ca(2+) stores and that this pathway is defective in JP1 KO myotubes
Skeletal muscle JP1/2 damage is significantly associated with early (0-3 days) strength deficits after performance of eccentric contractions.
Abnormal junctional membrane structures in cardiac myocytes in transgenic mice expressing junctophilin type 1.
We report a novel Junctophilin subtype, JP-4, encoded in the human (chromosome 14q11.1) and mouse (chromosome 14C1-2) genomes. JP-4 shares characteristic structural features with other JP subtypes, and is found in the brain.
Junctophilins support the Ca(2+)-mediated communication between voltage-gated Ca(2+) channels, which modulates the excitability of Purkinje cells and is fundamental to cerebellar long-term depression and motor functions.
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.
junctophilin type 1
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