Iron-Sulfur Cluster Scaffold Homolog (E. Coli) 蛋白 (ISCU)

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. 再加上,我们可以发ISCU 抗体 (61)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
ISCU 23479 Q9H1K1
大鼠 ISCU ISCU 288740  
ISCU 66383 Q9D7P6
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,465.26
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) His tag 50 μg Log in to see 15至19个工作日
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酵母菌 Shigella flexneri His tag   1 mg Log in to see 60至71个工作日
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非结合性   50 μg Log in to see 6 Days
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ISCU 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

更多Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU)互动伙伴

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. we report the first heterozygous dominant mutation in ISCU; notably, this alteration resulted in a similar phenotype as the recessive ISCU disease previously described.

  2. When ISCU was replaced by the fully structured variant ISCU(M108I), the addition of rdFDX2 to the [NIA-ISCU(M108I)-FXN (显示 FXN 蛋白)]2 complex led to the release of FXN (显示 FXN 蛋白). Thus, the displacement of FXN (显示 FXN 蛋白) by rdFDX2 explains the failure of FXN (显示 FXN 蛋白) to stimulate Fe-S cluster assembly on ISCU(M108I).

  3. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (显示 SDHB 蛋白) in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  4. The NFS1 (显示 NFS1 蛋白)/ISD11 (显示 LYRM4 蛋白) complex further interacts with scaffold protein (显示 HOMER1 蛋白) ISCU and regulator protein frataxin (显示 FXN 蛋白), thereby forming a quaternary complex for Fe-S cluster formation.

  5. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (显示 FXN 蛋白)(42-210)]24.[NFS1 (显示 NFS1 蛋白)]24.[ISD11 (显示 LYRM4 蛋白)]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  6. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (显示 TP53 蛋白) mutation.

  7. Thus, driven by acquired (hypoxia) or genetic causes, the miR (显示 MLXIP 蛋白)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  8. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  9. IscU is a new substrate of MK2 (显示 KCNA2 蛋白) both in Drosophila cells and in human cells

  10. Fe-S assembly protein (ISCU2) and frataxin (显示 FXN 蛋白) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (显示 TP53 蛋白) mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma (显示 IFNG 蛋白) alone induced Nfs1 (显示 NFS1 蛋白) protein instability, LPS (显示 TLR4 蛋白) triggered a delayed decline of Nfs1 (显示 NFS1 蛋白), rather involving transcriptional events or mRNA instability.

蛋白简介ISCU

蛋白简介

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene names and symbols associated with ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (LOC409130)
  • iron-sulfur cluster assembly enzyme (ISCU)
  • iron-sulfur cluster assembly enzyme a (iscua)
  • iron-sulfur cluster assembly enzyme (Iscu)
  • 2310020H20Rik 蛋白
  • AA407971 蛋白
  • HML 蛋白
  • hnifU 蛋白
  • ISU2 蛋白
  • Nifu 蛋白
  • Nifun 蛋白
  • RGD1309562 蛋白
  • si:ch211-191d15.3 蛋白
  • zC191D15.3 蛋白

Protein level used designations for ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPECIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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