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IL32A encodes a member of the cytokine family.
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Human Polyclonal IL32A Primary Antibody for ELISA, WB - ABIN1043804
Nishida, Andoh, Inatomi, Fujiyama: Interleukin-32 expression in the pancreas. in The Journal of biological chemistry 2009
Strong expression of IL-32 (显示 IL32 抗体) was detected in cardiomyocytes from heart failure patients.
The increase in serum levels of IL-32 (显示 IL32 抗体) in accordance with additive effect of the presence of C allele in Multiple sclerosis patients might introduce IL-32 (显示 IL32 抗体) as a key player in MS pathogenesis or immunedysregulation
Collectively, these results demonstrated that IL-32alpha upregulates the atheroprotective genes Timp3 (显示 TIMP3 抗体) and Reck (显示 RECK 抗体) by downregulating microRNA-205 through regulation of the Rprd2-Dgcr8 (显示 DGCR8 抗体)/Ddx5 (显示 DDX5 抗体)-Dicer1 (显示 DICER1 抗体) biogenesis pathway.
high expression of both IL17A (显示 IL17A 抗体) and IL32 (显示 IL32 抗体) leads to enhancement of T cell responses in breast tumors
High IL32 (显示 IL32 抗体) expression is associated with lung metastasis in melanoma.
In Kaposi sarcoma (KS) splicing ratio of the IL-32 (显示 IL32 抗体) isoforms showed IL-32gamma as the highest expressed isoform, followed by IL-32beta, in HIV-related KS cases compared with controls. Our data suggest a possible survival mechanism by the splicing of IL-32gamma to IL-32beta and also IL-6 (显示 IL6 抗体), IL-8 (显示 IL8 抗体), and CXCR1 (显示 CXCR1 抗体) signaling pathways to reverse the proapoptotic effect of the IL-32gamma isoform, leading to tumor cell survival and th...
Three single nucleotide polymorphisms (SNPs) (rs28372698, rs12934561, rs4786370) of the IL32 (显示 IL32 抗体) gene have been proposed as modifiers for different diseases. The present study found no significant differences in the genotypic frequencies between the patients and healthy controls and no relation to survival for any of the SNPs.
This study showed that the induction level of IL-32 (显示 IL32 抗体) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (显示 IRF6 抗体)-induced IL-32 (显示 IL32 抗体) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (显示 TLR4 抗体)/JNK (显示 MAPK8 抗体)/AKT (显示 AKT1 抗体)/CREB (显示 CREB1 抗体) signaling pathway.
findings show that IL-32alpha acts on NK cells to inhibit IL-15 (显示 IL15 抗体)-mediated STAT5 (显示 STAT5A 抗体) phosphorylation and to suppress their IL-15 (显示 IL15 抗体)-induced effector molecule expression and cytolytic capacity. IL-32alpha also acted on DCs by downregulating IL-15 (显示 IL15 抗体)-induced IL-18 (显示 IL18 抗体) production, an important cytokine in NK cell activity.
Thus, endogenous IL-32 (显示 IL32 抗体) is a crucial cytokine involved in the host defense against Leishmania parasites.
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, interleukin-32 eta
, interleukin-32 small
, interleukin-32 theta
, natural killer cell transcript 4
, natural killer cells protein 4
, tumor necrosis factor alpha-inducing factor