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The protein encoded by IL10RB belongs to the cytokine receptor family.
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Human IL10RB Protein expressed in Wheat germ - ABIN1307668
Frede, Glocker, Wanders, Engelhardt, Kreisel, Ruemmele, Grimbacher: Evidence for non-neutralizing autoantibodies against IL-10 signalling components in patients with inflammatory bowel disease. in BMC immunology 2014
We identified 32 compound heterozygous mutations and 9 homozygous mutations in IL10 receptor subunit alpha (显示 IL10RA 蛋白) and 1 homozygous mutation in IL10 receptor subunit beta. Among these mutations, 10 novel mutations were identified, and 6 pathogenic mutations had been previously described. In patients with IL10 receptor subunit alpha (显示 IL10RA 蛋白) mutations, c.301C>T (p.R101RW) and c.537 G>A (p.T179T) were the most common mutations.
IL-10 (显示 IL10 蛋白) and IL-10R gene polymorphisms may not contribute to the susceptibility to MM but may be associated with the severity and prognosis of MM. In particular, IL-10RB K47E polymorphism may contribute to the poor prognosis of MM patients treated with thalidomide and/or bortezomib.
systemic mRNA expression of IL10RB strongly differentiated children who failed to achieve asthma control with triamcinolone administration
Expression of IL10R (显示 IL10RA 蛋白) subunits within the leukocyte population (CD45 (显示 PTPRC 蛋白)(+) cells) was significantly higher in primary brain tumors than in metastases.
IL10R2 Overexpression promotes IL22 (显示 IL22 蛋白)/STAT3 (显示 STAT3 蛋白) signaling in colorectal carcinogenesis.
genetic association study in cohort of infants/children: Data suggest perianal fistulas are exhibited in patients with very early-onset inflammatory bowel disease with IL10 (显示 IL10 蛋白) receptor mutations (IL10RA (显示 IL10RA 蛋白)/B); prognosis and response to treatment are poor.
High IL10RB expression is associated with diffuse large B-cell lymphoma.
Inflammatory bowel disease (IBD) in infancy is phenotypically and genetically different disease entity from adult-onset or older child-onset IBD. It has a strong association with IL-10 (显示 IL10 蛋白) receptor gene.
PAPL, IL10RB and DEPDC5 polymorphisms have an impact on progression of hepatitis B virus-related liver disease.
Results show that the distribution of IL10RB and IL28RA (显示 IL28RA 蛋白) genotypes among the Hepatitis C virus-infected and control groups did not differ significantly.
The investigation of the IL-10R complex revealed that both the extracellular and intracellular domains of IL-10R2 influence the conformation of IL-10R1 (显示 IL10RA 蛋白) and that both domains were required for transducing IL-10 (显示 IL10 蛋白) signals.
evaluation of the ability of specific fatty acids to modulate production of the proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha (显示 TNF 蛋白)), and the anti-inflammatory cytokine, interleukin-10 (IL-10 (显示 IL10 蛋白)), in murine 3T3-L1 adipocytes
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.
cytokine receptor family II, member 4
, interleukin-10 receptor subunit beta
, interleukin 10 receptor, beta
, interleukin 10 receptor, 2
, IL-10 receptor subunit beta
, IL-10R subunit 2
, IL-10R subunit beta
, cytokine receptor class-II CRF2-4
, cytokine receptor class-II member 4
, cytokine receptor family 2 member 4
, interleukin-10 receptor subunit 2
, interleukin 10 receptor 2