Immune Receptor Expressed On Myeloid Cells 1 蛋白 (IREM1)

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. 再加上,我们可以发Immune Receptor Expressed On Myeloid Cells 1 抗体 (81)Immune Receptor Expressed On Myeloid Cells 1 试剂盒 (17)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
IREM1 246746 Q6SJQ7
IREM1 287818 Q566E6
IREM1 146722 Q8TDQ1
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
$5,262.31
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,370.21
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,370.21
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
$7,493.38
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大肠杆菌(E. Coli) 小鼠 His tag,GST tag 100 μg Log in to see 15至18个工作日
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人细胞 Fc Tag SDS-PAGE 50 μg Log in to see 14至16个工作日
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 11 Days
$411.40
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酵母菌 His tag 100 μg Log in to see 8至11个工作日
$484.00
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
$2,370.50
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大肠杆菌(E. Coli) 小鼠 非结合性   100 μg Log in to see 11至18个工作日
$582.75
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IREM1 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,
, ,
Rat (Rattus)

Human , , ,
, ,

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Mouse (Murine) Immune Receptor Expressed On Myeloid Cells 1 (IREM1) interaction partners

  1. Docking of the cocomplex structures onto a cryo-EM-derived model of MNoV suggests that each virion can make multiple CD300lf engagements, and thus, infection may be driven by the avidity of cell surface clustered CD300lf.

  2. sCD300lf bound on the mouse norovirus P domain. The receptor-binding site was located on the topside of the P2 subdomain and involved hydrophilic and hydrophobic interactions. The sCD300lf bound in a small cavity and was further supported by a positive surface charge on the sCD300lf and negative surface charge on the P domain.

  3. Our results indicate that direct interaction of MNV with two cell-surface molecules, CD300lf and CD300ld, dictates permissive noroviral infection.

  4. CD300f helps to maintain immune homeostasis by promoting macrophage clearance of self-antigens, while conversely inhibiting DC uptake and presentation of self-antigens.

  5. dextran sodium sulfate-treated Cd300f-/- mice exhibit attenuated disease activity and histopathology in comparison with wild type controls

  6. data highlight a previously unappreciated role for dendritic cells in controlling gut homeostasis and show that CD300f-dependent regulation of apoptotic cell uptake is essential for suppressing overactive dendritic cell-mediated inflammatory responses, thereby controlling the development of chronic gut inflammation.

  7. ceramide-CD300f binding inhibits LPS-induced skin inflammation, implicating CD300f as a negative regulator of Toll-like receptor 4 (TLR4) signaling in vivo

  8. CD300lf is essential for murine noroviruse binding and replication in cell lines and primary cells.

  9. CD300f is implicated in Wallerian degeneration and nerve regeneration by modulating both the influx and phenotype of macrophages

  10. Y276 phosphorylation is necessary for enhanced CD300f-mediated phagocytosis through the recruitment of the p85alpha regulatory subunit of phosphatidylinositol-3-kinase

  11. data highlight a previously unidentified role for CD300f in IL-4Ralpha-induced immune cell responses

  12. CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis.

  13. Several extracellular lipids (including ceramide) and lipoproteins were possible ligands for LMIR3.

  14. We conclude that expression of CD300f conveys additional capacity to recognize phosphatidylserine to myeloid cells.

  15. CLM-1 as a negative regulator of myeloid effector cells in autoimmune demyelination.

  16. DIgR2 is a functionally inhibitory receptor and can mediate negative signaling to regulate DC-initiated antigen-specific T-cell responses.

  17. the innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4

  18. These results indicate that CD300LF mediates caspase and endoplasmic reticulum stress-independent cell death by a novel mechanism.

  19. LMIR3 has a unique property to associate with FcRgamma and thereby functions as an activating receptor in concert with TLR4 stimulation

Human Immune Receptor Expressed On Myeloid Cells 1 (IREM1) interaction partners

  1. this study demonstrates the role of CD300f in governing innate immune eosinophil activities in pediatric Crohn's disease patients and in active ulcerative colitis patients

  2. findings suggest that two rare heterozygous truncating variations (RPS24 Q191X and CD300LF P261fsX266) are risk candidates for autism spectrum disorder.

  3. CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.

  4. The data suggest that the neuroprotective role of CD300f would be the result of a complex network of cell interactions.

  5. peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling

  6. CD300f blocked the activation of cells induced by all TLR ligands

  7. Data indicate that CD300F is an active regulator of TLR-mediated macrophage activation through association with SHP-1 involving MyD88 and/or TRIF.

  8. Findings indicate that IREM-1 exerted its inhibitory effect on BAFF-medicated signalling through ITIM-mediated regulation of ERK activities in THP-1 cells.

  9. IgSF13 was identified from dendritic cells; preferentially expressed in myelo-monocytic cells, including monocytes, monocyte-derived DC and monocyte-related cell lines; may be involved in the negative regulation of specific leukocyte population [IgSF13]

  10. a novel inhibitory receptor of the Ig superfamily in myeloid cells. (IREM-1 = immune receptor expressed on myeloid cells-1)

  11. reveal a putative functional duality of the IREM-1 myeloid cell receptor

蛋白简介Immune Receptor Expressed On Myeloid Cells 1 (IREM1)

蛋白简介

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6\; MIM 176883) or SHIP (INPP5D\; MIM 601582) (Sui et al., 2004

Gene names and symbols associated with IREM1

  • CD300 molecule like family member F (Cd300lf)
  • Cd300 molecule-like family member F (Cd300lf)
  • CD300 molecule like family member f (CD300LF)
  • CD300f 蛋白
  • CLIM1 蛋白
  • CLM-1 蛋白
  • CLM1 蛋白
  • Digr2 蛋白
  • F730004D16Rik 蛋白
  • IgSF13 蛋白
  • IREM-1 蛋白
  • IREM1 蛋白
  • LMIR3 蛋白
  • NKIR 蛋白
  • Pigr3 蛋白
  • RGD1309733 蛋白

Protein level used designations for IREM1

CD300 antigen-like family member F , CMRF-35-like molecule 1 , CMRF35-like molecule 1 , DC-derived Ig-like receptor 2 , MAIR-5 , MAIR-V , leukocyte mono-Ig-like receptor 3 , myeloid-associated immunoglobulin-like receptor 5 , CD300 antigen like family member F , CLM-1 , CD300 molecule like family member f , NK inhibitory receptor , immune receptor expressed on myeloid cells 1 , immunoglobin superfamily member 13 , immunoglobulin superfamily member 13 , inhibitory receptor IREM1

GENE ID SPECIES
246746 Mus musculus
287818 Rattus norvegicus
146722 Homo sapiens
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