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HOXD11 belongs to the homeobox family of genes. 再加上，我们可以发Homeobox D11 蛋白 (6) 和 和数多这个蛋白质的别的产品。
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Knock down of the dickkopf (显示 DKK1 抗体) WNT (显示 WNT2 抗体) signaling pathway inhibitor 2 (DKK2 (显示 DKK2 抗体)) resulted in a significant suppression of HOXD10 (显示 HOXD10 抗体), HOXD11 and HOXD13 (显示 HOXD13 抗体) while over-expression of DKK2 (显示 DKK2 抗体) and stimulation with factors of the WNT (显示 WNT2 抗体) signaling pathway.
High expression of HOXD11 is associated with laryngeal squamous cell carcinoma.
POU2F1 (显示 POU2F1 抗体) activity regulates HOXD10 (显示 HOXD10 抗体) and HOXD11 gene expression in head and neck squamous cell carcinoma, promoting a proliferative and invasive phenotype.
data show no significant difference in HOXD11, HOXD12 (显示 HOXD12 抗体) & HOXD13 (显示 HOXD13 抗体) genotype frequencies between the autism spectrum disorder & healthy controls, but one SNP in promoter region of HOXD11 was observed in only 4 patients with ASD (显示 ARSD 抗体)
In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (显示 HOXD12 抗体) (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease (显示 DCLRE1C 抗体) sensitivity as hESCs differentiate.
The HOXD11 gene is fused to the NUP98 (显示 NUP98 抗体) gene in acute myeloid leukemia (显示 BCL11A 抗体) with t(2;11)(q31;p15 (显示 CDKN2B 抗体)).
Our findings do not support the hypothesis that mutations in the HOXD11 coding regions are involved in the pathogenesis of human non-syndromal congenital renal parenchymal malformations.
expressed adjacent to the pisiform in late-stage embryonic limbs, supporting a role for Hox (显示 MSH2 抗体) genes in growth plate specification
Hoxa11 (显示 HOXA11 抗体) and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 (显示 RUNX2 抗体) and Shox2 (显示 SHOX2 抗体) in mice.
Hox11 (显示 TLX1 抗体) genes (Hoxa11 (显示 HOXA11 抗体), Hoxc11 (显示 HOXC11 抗体) and Hoxd11) co-regulate and coordinate the development of zeugopod skeletal elements and adjacent elbow and knee joints, and dictate joint identity, morphogenesis and anatomical and functional organization.
mice individually mutant for Hoxa11 (显示 HOXA11 抗体) or Hoxd11 show no discernible kidney abnormalities. Hoxa11 (显示 HOXA11 抗体)/Hoxd11 double mutants, however, demonstrate hypoplasia of the kidneys
analysis of the Hoxd11 duplication demonstrated that the Hoxd11 can perform some functions supplied by its paralogue Hoxa11 (显示 HOXA11 抗体), the defects in forelimb bones are corrected when extra copies of Hoxd11 are present in the Hoxa11 (显示 HOXA11 抗体) homozygous mutant background
malformation of the forelimb zeugopod in Hoxa11 (显示 HOXA11 抗体)/Hoxd11 double mutants is a consequence of interruption at multiple steps during the formation of the radius and ulna
early posterior restriction of Hox (显示 MSH2 抗体) gene products sets up an anterior-posterior prepattern, which determines the localized activation of Shh (显示 SHH 抗体); this signal is then translated into digit morphological asymmetry by promoting the late expression of Hoxd genes
identify the multiple molecular pathways downstream of Hoxa11 (显示 HOXA11 抗体)/Hoxd11 function in the developing kidney
Mice lacking all Hox11 (显示 TLX1 抗体) activity fail to form metanephric kidney structures; when Hoxd11 is ectopically activated in the anterior mesonephros, we observe a partial transformation to a metanephric program of development.
mice mutant for Hoxd11 and Hoxa11 (显示 HOXA11 抗体) show absence of radius and ulna, anterior homeotic transformation of vertebra, and severe kidney defects, suggesting Hoxd11 and Hoxa11 (显示 HOXA11 抗体) act together to specify limb outgrowth and patterning of proximodistal axis
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis.
Hox-4.6, mouse, homolog of
, homeo box 4F
, homeo box D11
, homeobox protein Hox-4F
, homeobox protein Hox-D11
, homeobox protein Hox-4.6
, homeobox protein Hox-5.5
, homeobox gene D-11
, homeobox protein Hox-C11
, homeobox protein Hox-D11a
, Hox D11
, homeobox protein Hox-4E
, homeodomain-containing protein
, homeobox D11
, LOW QUALITY PROTEIN: homeobox protein Hox-D11