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HOXC4 belongs to the homeobox family of genes. 再加上，我们可以发Homeobox C4 蛋白 (6) 和 Homeobox C4 试剂盒 (2)和数多这个蛋白质的别的产品。
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HOXC4 homeoprotein expands human hematopoietic immature cells by 3 to 6 times ex vivo and significantly improves the level of in vivo engraftment.
Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 (显示 HOXC6 抗体) in lymphocytic progenitor cells.
Esr1 (显示 ESR1 抗体) bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation.
Selective inhibition of class switching to IgG and IgE by recruitment of this and Oct-1 (显示 POU2F1 抗体) proteins and Ku70 (显示 XRCC6 抗体)/Ku86 (显示 XRCC5 抗体) to newly identified ATTT cis (显示 CISH 抗体)-elements.
The hs1,2mediated enhancement of V(H) and C(H) promoter-driven transcription as induced by HoxC4 and Oct-1/Oct-2 suggests an important role of these homeodomain proteins in the overall regulation of the IgH locus expression.
The HOXC4 expression was clearly detected in all inv (显示 INVS 抗体)(7) positive patients.
HoxC4 directly activates the Aicda (显示 AICDA 抗体) promoter
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (显示 HOXA1 抗体), HoxA5 (显示 HOXA5 抗体), HoxC4 &HoxC8 (显示 HOXC8 抗体) markedly enhanced. Irrespective of presence or absence of T3, insulin (显示 INS 抗体) down regulates HoxA10 (显示 HOXA10 抗体). T3 results in over expression of HoxA5 (显示 HOXA5 抗体), HoxC4 and HoxC8 (显示 HOXC8 抗体) genes, whereas insulin (显示 INS 抗体) up regulates expression of only HoxC8 (显示 HOXC8 抗体)
NF-kappaB (显示 NFKB1 抗体) mediates APRIL-induced HoxC4 transcription.
These findings suggest that in lupus B cells, upregulation of HoxC4 plays a major role in dysregulation of AID expression.
Quantitative RNA analysis for the genes flanking the breakpoint indicated no changes in expression levels except for some homeobox (显示 PRRX1 抗体) C (Hoxc) genes whose expression was elevated in developing and mature skin of the ears but not of other body regions.
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.
homeobox protein Hox-C4
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