anti-Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) 抗体

Expression of HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. 再加上,我们可以发HEXIM1 蛋白 (11)HEXIM1 试剂盒 (9)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
HEXIM1 10614 O94992
HEXIM1 192231 Q8R409
HEXIM1 498008 Q5M9G1
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Showing 10 out of 141 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
山羊 非结合性 ELISA, WB ABIN334418 (0.3µg/ml) staining of 1) HeLa cell lysate and 2) recombinant HEXIM1 (3ng). Detected by chemiluminescence. Data kindly provided by David Price and Jeff Coopper, University of Iowa, USA. ABIN334418 (0.1µg/ml) staining of Human (A) and Mouse (B) Heart lysates (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
$429.84
详细
Cow 非结合性 WB WB Suggested Anti-HEXIM1 Antibody Titration:  0.6ug/ml  ELISA Titer:  1:12500  Positive Control:  Jurkat cell lysate 100 μL Log in to see 2至3个工作日
$229.00
详细
小鼠 非结合性 IHC (p), WB HEXIM1 antibody (Center) (ABIN655589) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10至11个工作日
$385.00
详细
非结合性 IHC (p), WB HEXIM1 Antibody (N-term)  western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the HEXIM1 antibody detected the HEXIM1 protein (arrow). HEXIM1 Antibody (N-term)  western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the HEXIM1 antibody detected the HEXIM1 protein (arrow). 400 μL Log in to see 10至11个工作日
$385.00
详细
非结合性 EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue reacted with AP52035PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of HEXIM1 antibody (Center) in mouse liver tissue lysates (35ug/lane). This demonstrates the HEXIM1 antibody detected the HEXIM1 protein (arrow). 0.4 mL Log in to see 6至8个工作日
$484.00
详细
非结合性 IF, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using HEXIM1 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using HEXIM1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 IC, IF, IHC, WB   200 μL Log in to see 13至14个工作日
$487.50
详细
非结合性 ELISA, IF, IHC, IHC (p), WB Human, Small intestine: Formalin-Fixed Paraffin-Embedded (FFPE) 50 μL Log in to see 11至14个工作日
$484.00
详细
Bat 非结合性 WB 100 μg Log in to see 11至14个工作日
$493.17
详细
Bat 山羊 非结合性 ELISA, WB 100 μg Log in to see 11至14个工作日
$610.50
详细

引用最多的anti-HEXIM1 抗体

  1. Human Polyclonal HEXIM1 Primary Antibody for WB - ABIN2801953 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal HEXIM1 Primary Antibody for ELISA, WB - ABIN188667 : Schulte, Czudnochowski, Barboric, Schönichen, Blazek, Peterlin, Geyer: Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat. in The Journal of biological chemistry 2005 (PubMed)

更多抗HEXIM1的相互作用对抗体

Human Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) interaction partners

  1. The 7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (P-TEFb). And in addition to its action on P-TEFb, it plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets.

  2. We conclude that the degradation of NPM1 and HEXIM1 through autophagy in certain AML subsets contributes to the activation of the BET pathway in these cells.

  3. Identify a HEXIM1-containing ribonuclear protein complex composed also of DNA-PK, paraspeckle subunits, and the long non-coding RNA (lncRNA) NEAT1, which acts as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway.

  4. HMBA and derivative HMBA4a1 induce HEXIM1 activity, targeting several signaling pathways critical in tumorigenesis and metastasis.

  5. HSP70 activator shows similar activity as HMBA and 4a1 to induce HEXIM1 expression, suggesting that HMBA and 4a1 might be putative HSP70 activators

  6. Our results demonstrated that HEXIM1 exhibited the most consistent response to BET inhibitors in all of the settings examined, including tumors and surrogate tissues.

  7. Suggest that greater tumor associated macrophage density, strong Hexim1 expression, strong SMAD2 expression, and mild SMAD7 expression play important roles in the progression of prostate adenocarcinoma.

  8. Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes.

  9. Data indicate the binding of RNA-binding protein HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE and LARP7.

  10. PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP.

  11. This study demonstrates a novel role of HEXIM1 in regulating human pluripotent stem cells fate through a P-TEFb-independent pathway.

  12. HEXIM1 functions as an AR (androgen receptor) co-repressor as it physically interacts with the AR and is required for the ability of anti-androgens to inhibit androgen-induced target gene expression and cell proliferation.

  13. the release of P-TEFb from the 7SK snRNP led to increased synthesis of HEXIM1 but not HEXIM2

  14. There is evidence for a direct interaction between HIF-1alpha and HEXIM1, and HEXIM1 up-regulated hydroxylation of HIF-1alpha.

  15. P-TEFb/HEXIM1-dependent transcriptional regulation may play a pathophysiological role in RVH and be a novel therapeutic target for mitigating RVH in PAH

  16. results not only identify HEXIM1 as a positive regulator of p53, but also propose a novel molecular mechanism of p53 activation caused by the anti-cancer drugs and compounds.

  17. Changes in Hexim-1 protein expression and cellular distribution significantly influence androgen receptor activation and transforming growth factor (TGF)-beta signaling in prostate cancer progression.

  18. N-terminal residues in cyclin T1 are specifically involved in the binding of cyclin T1 to HEXIM1 but not to Tat.

  19. Structural insights were provided into the recognition of the regulator protein Hexim1 by P-TEFb and the modulation of coiledcoil dynamics by specific discontinuities.

  20. Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb.

Cow (Bovine) Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) interaction partners

  1. The authors demonstrate that bovine hexamethylene bisacetamide-induced protein 1 (BHEXIM1) inhibits the bovine immunodeficiency virus-mediated BIV LTR transcription. In vivo and in vitro assays show direct binding of BHEXIM1 to the bovine cyclin T1.

Mouse (Murine) Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1) interaction partners

  1. Trypanosoma cruzi (T. cruzi) infected mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene have compromised cardiac function, altered expression of both pro- and anti-inflammatory cytokines, and increased inflammation and fibrosis. The profound exacerbation of pathologic findings in the tissues of heart, lung, spleen, and intestines suggests a protective role for Hexim1 in T. cruzi infection.

  2. Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 respectively.

  3. Hexim1 selectively modulates leptin-mediated signal transduction pathways in the hypothalamus.

  4. conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition

  5. HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy

  6. re-expression of HEXIM1 in mammary epithelial cells resulted in inhibition of metastasis to the lung

  7. a crucial role for the HEXIM1/P-TEFb pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases.

  8. Our findings underscore the critical role of CLP-1 in remodeling of the genetic response during hypertrophy and fibrosis.

  9. these results show that the improvement in cardiac function in CLP-1(+/-) mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling.

  10. CLP-1 and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy

  11. HEXIM1 plays critical roles in coronary vessel development and myocardial growth

  12. the reduced level of CLP-1 introduced in the background of elevated levels of cyclin T1 elevates derepression of P-TEFb activity and emphasizes the importance of the role of CLP-1 in the mechanism governing compensatory hypertrophy in cardiomyocytes.

HEXIM1 抗原简介

蛋白简介

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.

Gene names and symbols associated with HEXIM1

  • hexamethylene bisacetamide inducible 1 (HEXIM1) 抗体
  • hexamethylene bis-acetamide inducible 1 (hexim1) 抗体
  • hexamethylene bis-acetamide inducible 1 (Hexim1) 抗体
  • hexamethylene bis-acetamide inducible 1 L homeolog (hexim1.L) 抗体
  • 7330426E13Rik 抗体
  • Clp-1 抗体
  • Clp1 抗体
  • EDG1 抗体
  • fd44h02 抗体
  • hexim 抗体
  • HEXIM1 抗体
  • HIS1 抗体
  • MAQ1 抗体
  • wu:fd44h02 抗体
  • zgc:162976 抗体

Protein level used designations for HEXIM1

hexamethylene bis-acetamide inducible 1 , HMBA-inducible , protein HEXIM1 , protein HEXIM1-like , protein HEXIM , cardiac lineage protein 1 , estrogen down-regulated gene 1 protein , hexamethylene bis-acetamide-inducible protein 1 , hexamethylene bisacetamide-inducible protein , hexamethylene-bis-acetamide-inducible transcript 1 , hexamthylene bis-acetamide inducible 1 , menage a quatre 1 , menage a quatre protein 1 , HMBA-inducible 1

GENE ID SPECIES
454746 Pan troglodytes
716006 Macaca mulatta
100339675 Oryctolagus cuniculus
100601526 Nomascus leucogenys
562319 Danio rerio
10614 Homo sapiens
606811 Canis lupus familiaris
539696 Bos taurus
192231 Mus musculus
498008 Rattus norvegicus
735111 Xenopus laevis
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