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Expression of HEXIM1 is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells.
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Human Polyclonal HEXIM1 Primary Antibody for WB - ABIN2801953
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Human Polyclonal HEXIM1 Primary Antibody for ELISA, WB - ABIN188667
Schulte, Czudnochowski, Barboric, Schönichen, Blazek, Peterlin, Geyer: Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat. in The Journal of biological chemistry 2005
We conclude that the degradation of NPM1 (显示 NPM1 抗体) and HEXIM1 through autophagy in certain AML (显示 RUNX1 抗体) subsets contributes to the activation of the BET pathway in these cells.
Identify a HEXIM1-containing ribonuclear protein complex composed also of DNA-PK, paraspeckle subunits, and the long non-coding RNA (lncRNA) NEAT1, which acts as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway.
HMBA and derivative HMBA4a1 induce HEXIM1 activity, targeting several signaling pathways critical in tumorigenesis and metastasis.
HSP70 (显示 HSP70 抗体) activator shows similar activity as HMBA and 4a1 to induce HEXIM1 expression, suggesting that HMBA and 4a1 might be putative HSP70 (显示 HSP70 抗体) activators
Our results demonstrated that HEXIM1 exhibited the most consistent response to BET inhibitors in all of the settings examined, including tumors and surrogate tissues.
Suggest that greater tumor associated macrophage density, strong Hexim1 expression, strong SMAD2 (显示 SMAD2 抗体) expression, and mild SMAD7 (显示 SMAD7 抗体) expression play important roles in the progression of prostate adenocarcinoma.
Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes.
Data indicate the binding of RNA-binding protein (显示 PTBP1 抗体) HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE (显示 MEPCE 抗体) and LARP7 (显示 LARP7 抗体).
PPM1G (显示 PPM1G 抗体) phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb (显示 CCNT1 抗体) has been released from the 7SK snRNP (显示 LSM2 抗体).
This study demonstrates a novel role of HEXIM1 in regulating human pluripotent stem cells fate through a P-TEFb (显示 CCNT1 抗体)-independent pathway.
The authors demonstrate that bovine hexamethylene bisacetamide-induced protein 1 (BHEXIM1) inhibits the bovine immunodeficiency virus-mediated BIV LTR transcription. In vivo and in vitro assays show direct binding of BHEXIM1 to the bovine cyclin T1 (显示 CCNT1 抗体).
Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE (显示 APOE 抗体) null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta (显示 TGFB1 抗体) pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 (显示 SOCS3 抗体) respectively.
Hexim1 selectively modulates leptin (显示 LEP 抗体)-mediated signal transduction pathways in the hypothalamus.
conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha (显示 HIF1A 抗体) and VEGF (显示 VEGFA 抗体) in the myocardium under hypoxic condition
HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy
re-expression of HEXIM1 in mammary epithelial cells resulted in inhibition of metastasis to the lung
a crucial role for the HEXIM1/P-TEFb (显示 CCNT1 抗体) pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases.
Our findings underscore the critical role of CLP-1 (显示 CNNM1 抗体) in remodeling of the genetic response during hypertrophy and fibrosis.
these results show that the improvement in cardiac function in CLP-1 (显示 CNNM1 抗体)(+/-) mice after ischemia-reperfusion injury is achieved through the potentiation of redox signaling.
CLP-1 (显示 CNNM1 抗体) and the HAND transcription factors may be part of a genetic program critical to proper heart development, and their perturbation can lead to cardiomyopathy
HEXIM1 plays critical roles in coronary vessel development and myocardial growth
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
hexamethylene bis-acetamide inducible 1
, protein HEXIM1
, protein HEXIM1-like
, protein HEXIM
, cardiac lineage protein 1
, estrogen down-regulated gene 1 protein
, hexamethylene bis-acetamide-inducible protein 1
, hexamethylene bisacetamide-inducible protein
, hexamethylene-bis-acetamide-inducible transcript 1
, hexamthylene bis-acetamide inducible 1
, menage a quatre 1
, menage a quatre protein 1
, HMBA-inducible 1