Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) ELISA试剂盒

HNRNPU belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). 再加上,我们可以发Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) 抗体 (65)Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) 蛋白 (5)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
HNRNPU 51810 Q8VEK3
HNRNPU 117280  
HNRNPU 3192 Q00839
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0.057 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13至16个工作日
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37.5 pg/mL 62.5-4000 pg/mL   96 Tests Log in to see 12至14个工作日
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豚鼠 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12至14个工作日
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小鸡 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12至14个工作日
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0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12至14个工作日
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1.0 ng/mL 2.5-50 ng/mL   96 Tests Log in to see 15至18个工作日
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< 0.057 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11至18个工作日
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适于 Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) interaction partners

  1. we demonstrated that HNRNPU functions as a major factor maintaining 3D chromatin architecture, suggesting important roles of NM-associated proteins in genome organization.

  2. We found that heterogeneous nuclear ribonucleoprotein U (hnRNP U) is essential for the expression of Avp (显示 AVP ELISA试剂盒) and Vip (显示 Vip ELISA试剂盒). Loss of one copy of the Hnrnpu gene resulted in fragmented locomotor activities and disrupted metabolic rhythms. Hnrnpu(+/-) mice were more active than wild-type mice in the daytime but more inactive at night.

  3. findings provide conclusive evidence for the essential role of hnRNP U in heart development and function and in the regulation of alternative splicing.

  4. SAF-A interacts with BRG1 and both components are required for RNA Polymerase II Mediated Transcription

  5. Macrophage expression of hnRNP U was induced by TLR stimulation. hnRNP U knockdown attenuated & overexpression increased TLR-induced expression of TNF-alpha (显示 TNF ELISA试剂盒), IL-6 (显示 IL6 ELISA试剂盒) & IL-1beta (显示 IL1B ELISA试剂盒). hnRNP U bound to the mRNA of these cytokines via the RGG motif.

  6. Data report that endogenous SAF-A is involved in regulation of Oct4 (显示 POU5F1 ELISA试剂盒) expression, binds the Oct4 (显示 POU5F1 ELISA试剂盒) proximal promoter in ES cells, and dissociates from the promoter upon early differentiation induced by LIF (显示 LIF ELISA试剂盒) withdrawal.

  7. hnRNP-U engages a highly neddylated active SCF (显示 KITLG ELISA试剂盒) beta-TrCP (显示 BTRC ELISA试剂盒) which dissociates in the presence of a high-affinity substrate, resulting in the ubiquitination of the latter.

  8. hnRNP U participates in nuclear regulatory events that are involved in mammalian central and peripheral circadian clocks.

  9. nuclear matrix protein SAF-A binds to the 3'-flanking region of the Bmal1 (显示 ARNTL ELISA试剂盒) gene with circadian timing

  10. HnRNP U binding to the 5'-UTR (显示 UTS2R ELISA试剂盒) of the Shh (显示 SHH ELISA试剂盒) facilitates gene expression during limb development.

Human Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) interaction partners

  1. This series demonstrates common phenotypic features, including emerging dysmorphism, associated with heterozygous HNRNPU mutations. This allows us to define a novel neurodevelopmental syndrome, with a likely mechanism of haploinsufficiency

  2. SAF-A, in concert with Ku, temporally regulates base damage repair in irradiated cell genome.

  3. HNRPU deletion is associated with neurodevelopmental disorders.

  4. We broaden the clinical and mutational HNRNPU-associated spectrum, and demonstrate that heterozygous HNRNPU variants cause epilepsy, severe intellectual disability with striking speech impairment and variable central nervous system, cardiac, and renal anomalies.

  5. Results show that SAF-A and caRNAs form a dynamic, transcriptionally responsive chromatin mesh that organizes large-scale chromosome structures and protects the genome from instability.

  6. results confirm and refine the complex genotype-phenotype correlations existing in the 1qter microdeletion syndrome and define more precisely the neurodevelopmental phenotypes associated with genetic alterations of AKT3 (显示 AKT3 ELISA试剂盒), ZBTB18 and HNRNPU in humans

  7. mutual regulatory mechanisms exist between PP4 (显示 ANXA5 ELISA试剂盒) and SAF-A. Interactions between PP4 (显示 ANXA5 ELISA试剂盒) and SAF-A played a role in prometaphase/metaphase transition.

  8. CENP-W (显示 CENPW ELISA试剂盒) interacts with hnRNPU and may contribute to kinetochore-microtubule attachment in mitotic cells.

  9. Nuclear TDP-43 becomes neurotoxic by escaping from the inhibitory regulation by hnRNP-U or hnRNP-A2. hnRNP-U inhibits TDP-43-mediated alterations in splicing of POLDIP3 mRNA.

  10. These results suggest that HNRNPU, FAM36A, and NCRNA00201 are not major genes for microcephaly and corpus callosum abnormalities but are good candidates for intellectual disability (ID) and seizures.

Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU) 抗原简介

Antigen Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with HNRNPU

  • heterogeneous nuclear ribonucleoprotein U (Hnrnpu) 抗体
  • heterogeneous nuclear ribonucleoprotein U (HNRNPU) 抗体
  • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) S homeolog (hnrnpu.S) 抗体
  • heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (HNRNPU) 抗体
  • AA408410 抗体
  • AI256620 抗体
  • AL024194 抗体
  • AL024437 抗体
  • AW557595 抗体
  • C86794 抗体
  • hnRNP U 抗体
  • HNRPU 抗体
  • saf-a 抗体
  • SAFA 抗体
  • SN1 抗体
  • Sp120 抗体
  • U21.1 抗体

Protein level used designations for HNRNPU

SAF-A , heterogenous nuclear ribonucleoprotein U , nuclear matrix protein sp120 , scaffold attachment factor A , system N1 Na+ and H+-coupled glutamine transporter , transporter protein , transporter protein; system N1 Na+ and H+-coupled glutamine transporter , heterogeneous nuclear ribonucleoprotein U , p120 nuclear protein , pp120

GENE ID SPECIES
51810 Mus musculus
117280 Rattus norvegicus
100348766 Oryctolagus cuniculus
3192 Homo sapiens
399374 Xenopus laevis
539950 Bos taurus
100515571 Sus scrofa
421492 Gallus gallus
100725944 Cavia porcellus
101107118 Ovis aries
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