Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) 蛋白 (HNRNPD)

HNRNPD belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). 再加上,我们可以发Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) 抗体 (118)Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) 试剂盒 (15)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HNRNPD 3184 Q14103
HNRNPD 79256 Q9JJ54
HNRNPD 11991 Q60668
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HNRNPD 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

更多Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) (HNRNPD)互动伙伴

Human Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) (HNRNPD) interaction partners

  1. Our study provides new insights into the regulation of APP (显示 APP 蛋白) pre-mRNA processing, supports the role for nELAVLs as neuron-specific splicing regulators and reveals a novel function of AUF1 in alternative splicing.

  2. Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism.

  3. Lnc_ASNR interacted with the protein ARE/poly (U)-binding/degradation factor 1(AUF1), which is reported to promote rapid degradation of the Bcl-2 (显示 BCL2 蛋白) mRNA, an inhibitor of apoptosis. Lnc_ASNR binds to AUFI in nucleus, decreasing the cytoplasmic proportion of AUF1 which targets the B-cell lymphoma-2 (Bcl-2 (显示 BCL2 蛋白)) mRNA.

  4. in the present case, the identified mutations in HNRNPD and risk polymorphisms are plausible molecular players in the manifestation of CD.

  5. AUF1 p45 (显示 CASP1 蛋白) triggers the RNA switch in the flaviviral genome that is crucial for viral replication. These findings represent an important example of how cellular (host) factors promote the propagation of RNA viruses

  6. AUF1 might be a potential player in renal tubulointerstitial fibrosis through modulation of TGF-beta (显示 TGFB1 蛋白) signal transduction via posttranscriptional regulation of Nedd4L (显示 NEDD4L 蛋白).

  7. Results indicate that the IL-6 (显示 IL6 蛋白)/STAT3 (显示 STAT3 蛋白)/NF-kappaB (显示 NFKB1 蛋白) positive feedback loop includes AUF1 and is responsible for the sustained active status of cancer-associated fibroblasts.

  8. Depletion of AUF1 abolishes the global interaction of miRNAs and AGO2 (显示 EIF2C2 蛋白). AUF1 functions in promoting miRNA-mediated mRNA decay globally.

  9. High AUF1 expression is associated with esophageal squamous cell carcinoma.

  10. Arginine methylation improves the viral RNA chaperone activity of AUF1 p45 (显示 CASP1 蛋白).

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) (HNRNPD) interaction partners

  1. Control of ARE-mRNA decay by AUF1 represents a mechanism for adult stem cell regulation.

  2. These results suggest that the post-transcriptional regulation of ATX (显示 ENPP2 蛋白) expression by HuR (显示 ELAVL1 蛋白) and AUF1 modulates cancer cell migration.

  3. MEF2C (显示 MEF2C 蛋白) is a key effector of the myogenesis program promoted by AUF1.

  4. hnRNP (显示 HNRNPH2 蛋白) D is critically involved in LDLR (显示 LDLR 蛋白) mRNA degradation in liver tissue in vivo.

  5. This study showed that arginines in the RGG domain of AUF1 are methylated, and AUF1-RGG peptides may be novel reagents that reduce macrophage activation in inflammation.

  6. Mitochondrial biogenesis occurs in the presence of increased CUG-BP1 (显示 CELF1 蛋白) and AUF1, suggesting that reductions in known mRNA destabilizing proteins likely does not contribute to exercise-induced mitochondrial biogenesis.

  7. Data show that AUF1 binds and strongly activates the transcription promoter for telomerase catalytic subunit Tert (显示 TERT 蛋白).

  8. These findings demonstrate that AUF1 regulates VEGF (显示 VEGFA 蛋白) expression, and this study identifies an RGG peptide that suppresses VEGF (显示 VEGFA 蛋白) gene expression.

  9. 30-kDa protein is a novel isoform of AUF1 family and is the main component of the DAP (显示 DAP 蛋白)-II complex that binds to the DAS (显示 ube3a 蛋白) sequence.

  10. p16( INK4a) is also a modulator of transcription and apoptosis through controlling the expression of two major transcription regulators, AUF1 and E2F1 (显示 E2F1 蛋白)

Xenopus laevis Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) (HNRNPD) interaction partners

  1. These results show that ElrA and AUF1 bind to cyclin B2 (显示 CCNB2 蛋白) mRNA independent of cytoplasmic polyadenylation elements and function by binding other elements.

Pig (Porcine) Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) (HNRNPD) interaction partners

  1. Concurrent binding and modifications of AUF1 and HuR (显示 ELAVL1 蛋白) mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase (显示 PEPCK 蛋白) mRNA in kidney cells.

  2. the renal proximal tubule, may require the remodeling of AUF1 binding to the elements that mediate the rapid turnover of PEPCK (显示 PEPCK 蛋白) mRNA.

蛋白简介Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) (HNRNPD)

蛋白简介

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.

Gene names and symbols associated with HNRNPD

  • heterogeneous nuclear ribonucleoprotein D (HNRNPD)
  • heterogeneous nuclear ribonucleoprotein D (Hnrnpd)
  • heterogeneous nuclear ribonucleoprotein D (hnrnpd)
  • heterogeneous nuclear ribonucleoprotein D L homeolog (hnrnpd.L)
  • Auf1 蛋白
  • auf1a 蛋白
  • C230004L04 蛋白
  • HNRNPD 蛋白
  • hnrnpd0 蛋白
  • Hnrpd 蛋白
  • p37 蛋白
  • wu:fa28b06 蛋白
  • zgc:162951 蛋白

Protein level used designations for HNRNPD

ARE-binding protein AUFI, type A , heterogeneous nuclear ribonucleoprotein D0 , hnRNP D0 , AU-rich element RNA-binding factor 1 , AU-rich element RNA-binding protein 1 , RNA binding protein p45AUF1 , heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) , AUF1 , p37 AUF1 , RNA binding protein

GENE ID SPECIES
3184 Homo sapiens
79256 Rattus norvegicus
422602 Gallus gallus
527471 Bos taurus
461216 Pan troglodytes
478450 Canis lupus familiaris
594903 Xenopus (Silurana) tropicalis
100294646 Ovis aries
11991 Mus musculus
496375 Xenopus laevis
560522 Danio rerio
100512244 Sus scrofa
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