Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) 蛋白 (HNRNPC)

HNRNPC belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). 再加上,我们可以发Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) 抗体 (126)Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) 试剂盒 (15)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HNRNPC 3183 P07910
HNRNPC 15381 Q9Z204
HNRNPC 290046  
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) His tag 50 μg Log in to see 15至19个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 非洲爪蟾 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 His tag   1 mg Log in to see 60至71个工作日
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非结合性   50 μg Log in to see 6 Days
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HNRNPC 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

更多Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC)互动伙伴

Human Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) interaction partners

  1. APP levels then decrease progressively as a function of age in close relationship with the gradual normalization of FMRP and hnRNP C levels.

  2. Endoplasmic reticulum resident chaperone GRP78, mitochondrial protein Prohibitin and heterogeneous nuclear ribonucleoprotein hnRNPC (C1/C2) have been shown to interact with viral RNA. Hence it is proposed that these are the principle candidates governing endoplasmic reticulum stress-induced apoptosis in JEV infection.

  3. Our results indicate that a balance between lncRNA SNHG1 and hnRNPC regulates p53 activity and p53-dependent apoptosis upon doxorubicin treatment, and further indicate that a change in lncRNA subcellular localization under specific circumstances is biologically significant.

  4. These data suggest an interplay between CELF2 and hnRNP C as the mechanistic basis for activation-dependent alternative splicing of TRAF3 exon 8.

  5. These data indicate that hnRNPC1/C2 binds to both DNA and RNA and influences both gene expression and RNA splicing, but these actions do not appear to be linked through 1,25(OH)2D-mediated induction of transcription.

  6. These findings suggest that hnRNP C1/C2 is involved in dengue virus replication at the stage of viral RNA synthesis.

  7. HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform.

  8. Our results suggested that hnRNP C1 controls HPV16 late gene expression.

  9. m(6)A-switch-regulated HNRNPC-binding activities affect the abundance as well as alternative splicing of target mRNAs, demonstrating the regulatory role of m(6)A-switches on gene expression and RNA maturation

  10. PTBP1 and hnRNP C repress exon 3 inclusion, and that downregulation of PTBP1 inhibited BIM-mediated apoptosis.

  11. down-regulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest

  12. Heterogeneous nuclear ribonucleoprotein C is a key regulator of BRCA gene expression and homologous recombination-based DNA repair.

  13. By preventing U2AF65 binding to Alu elements, hnRNP C plays a critical role as a genome-wide sentinel protecting the transcriptome.

  14. The data indicated that hnRNPC controls the aggressiveness of glioblastoma cells through the regulation of PDCD4. Silencing of hnRNPC lowered miR-21 levels, in turn increasing the expression of PDCD4, suppressing Akt and p70S6K activation.

  15. p27kip1 upregulated by hnRNPC1/2 antagonizes CagA-mediated pathogenesis.

  16. study shows mechanism by which Pol II transcripts are classified according to length; heterotetramer of hnRNP C1/C2 measures the length of the transcripts like a molecular ruler, by binding to unstructured RNA regions longer than 200 to 300 nucleotides

  17. One of the identified proteins, hnRNPC, was found to interact with small hepatitis delta virus antigen in vitro and in vivo in human liver cells.

  18. Studies indicated that DDX21, HNRNPC, and RCC2 were isolated from Ku86 multicomponent complex in response to DNA damage.

  19. HNRNP C recognizes uridine tracts with a defined long-range spacing consistent with HNRNP particle organization.

  20. FMRP represses translation by recruiting APP mRNA to processing bodies, whereas hnRNP C promotes APP translation by displacing FMRP, thereby relieving the translational block.

Mouse (Murine) Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) interaction partners

  1. APP levels then decrease progressively as a function of age in close relationship with the gradual normalization of FMRP and hnRNP C levels.

  2. hnRNP C and hnRNP H bind to the 3'-UTR of the circadian clock gene Period 2 (mPer2).

  3. Neither hnRNP-C nor FMRP is required for cyclic AMP to stimulate APP and Amyloid beta production.

  4. our results reveal a new function of the splicing factor hnRNP C in the maturation of dendritic cells that involves regulating the expression of NF-kappaB p65 and its downstream targets CD80 and CD40.

  5. CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C

  6. Data suggest that increased levels of hnRNP C1/C2 may modulate XIAP translation by interacting with the XIAP-IRES, and may foster synthesis of XIAP as a protective pathway by which neurons try to counteract the initial deleterious effects of apoptosis.

蛋白简介Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC)

蛋白简介

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.

Gene names and symbols associated with HNRNPC

  • heterogeneous nuclear ribonucleoprotein C (C1/C2) (HNRNPC)
  • heterogeneous nuclear ribonucleoprotein C (C1/C2) S homeolog (hnrnpc.S)
  • heterogeneous nuclear ribonucleoprotein C (hnrnpc)
  • heterogeneous nuclear ribonucleoprotein C (Hnrnpc)
  • heterogeneous nuclear ribonucleoprotein C (C1/C2) L homeolog (hnrnpc.L)
  • heterogeneous nuclear ribonucleoprotein C (C1/C2) (Hnrnpc)
  • AL022939 蛋白
  • bZ1G18.4 蛋白
  • C1 蛋白
  • C2 蛋白
  • D14Wsu171e 蛋白
  • fb57h12 蛋白
  • fi16b11 蛋白
  • hnrnp 蛋白
  • hnrnp-C 蛋白
  • hnRNP C 蛋白
  • HNRNPC 蛋白
  • hnRNPC1 蛋白
  • hnRNPC2 蛋白
  • hnrpc 蛋白
  • Hnrpc1 蛋白
  • Hnrpc2 蛋白
  • MGC53243 蛋白
  • snrpc 蛋白
  • wu:fb57h12 蛋白
  • wu:fi16b11 蛋白
  • zgc:55701 蛋白

Protein level used designations for HNRNPC

heterogeneous nuclear ribonucleoproteins C1/C2 , hnRNP C1/C2 , nuclear ribonucleoprotein particle C1 protein , nuclear ribonucleoprotein particle C2 protein , heterogeneous nuclear ribonucleoprotein C (C1/C2) , heterogeneous nuclear ribonucleoprotein C1 , heterogeneous nuclear ribonucleoprotein C2 , heterogeneous ribonucleoprotein C1/C2 , hnRNP C1 / hnRNP C2 , hnRNP C2 , snoRNA MBI-122 , heterogeneous nuclear ribonucleoprotein C , hnRNP C protein C-terminal fragment (158 AA) , hnRNP core protein C , hnRNP C , C protein

GENE ID SPECIES
3183 Homo sapiens
379948 Xenopus laevis
465214 Pan troglodytes
475399 Canis lupus familiaris
510852 Bos taurus
406352 Danio rerio
15381 Mus musculus
290046 Rattus norvegicus
100008686 Oryctolagus cuniculus
100860966 Capra hircus
397793 Xenopus laevis
100713856 Cavia porcellus
100059269 Equus caballus
100626496 Sus scrofa
101925475 Macaca fascicularis
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