Hes Family bHLH Transcription Factor 1 蛋白 (HES1)

This protein belongs to the basic helix-loop-helix family of transcription factors. 再加上,我们可以发HES1 抗体 (166)HES1 试剂盒 (16)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HES1 3280 Q14469
HES1 15205 P35428
HES1 29577 Q04666
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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小麦胚 GST tag 2 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) His tag Validation with Western Blot 50 μg Log in to see Available
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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酵母菌 非洲爪蟾 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 Cow His tag   1 mg Log in to see 60至71个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 小鸡 His tag   1 mg Log in to see 60至71个工作日
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大肠杆菌(E. Coli) His tag   10 μg Log in to see 5至8个工作日
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HES1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

更多Hes Family bHLH Transcription Factor 1 (HES1)互动伙伴

Human Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. HES1 is mono-ubiquitinated in a Fanconi anemia (显示 PALB2 蛋白) core complex-dependent manner.

  2. Hes-1 knockdown promotes osteopontin (显示 SPP1 蛋白) expression in HUVECs and enhances OPN (显示 SPP1 蛋白)-induced angiogenesis.

  3. Our results suggest that KN promotes goblet cell differentiation by regulating Wnt (显示 WNT2 蛋白), Notch (显示 NOTCH1 蛋白), and AhR (显示 AHR 蛋白) signals and expression of Hes1 and Hath1 (显示 ATOH1 蛋白).

  4. In the present study, the authors reported the first observation of Hes1 oscillatory expression in human neural progenitor /stem cells, with an approximately 1.5 hour periodicity and a Hes1 protein half-life of about 17 (17.6 +/- 0.2) minutes. Human cytomegalovirus infection disrupts the Hes1 rhythm and down-regulates its expression.

  5. A three-molecule score based on the expression of Notch (显示 NOTCH1 蛋白) pathway molecules: Jagged1 (显示 JAG1 蛋白), intracellular Notch1 (显示 NOTCH1 蛋白) (ICN1) and Hes1 (JIH score) to assess prognostic value in non-metastasis clear cell renal cell carcinoma (显示 MOK 蛋白) (ccRCC).

  6. we demonstrate for the first time an essential role of HPV oncoprotein E6 that selectively overexpresses in CaCxSLCs and participates in maintenance of stem cell phenotype and stemness through upregulation of Hes1 while preponderance of E7 leads to differentiation.

  7. IE1 is involved in Hes1 degradation by assembling a ubiquitination complex and promoting Hes1 ubiquitination as a potential E3 ubiquitin ligase (显示 MUL1 蛋白), followed by proteasomal degradation of Hes1.

  8. Notch (显示 NOTCH1 蛋白) signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch (显示 NOTCH1 蛋白).

  9. The phenotype was rescued by ectopic expression of miRNA182-5p in Delta182 cells. A bioinformatic analysis and Hes1 modulation data suggested that Hes1 could be a putative target of miRNA182-5p. A reciprocal relationship between miRNA182-5p and Hes1 was seen in the context of TK inhibition

  10. These results suggest that HES1 promotes extracellular matrix protein expression and inhibits proliferative and migratory functions in the trabecular meshwork cells under oxidative stress, thereby providing a novel pathogenic mechanism underlying and a potential therapeutic target to primary open-angle glaucoma

Mouse (Murine) Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia.

  2. the results raise the possibility that HES1 or other genes that affect HES1 expression could be involved in the etiology of Ectopic pancreas .

  3. These results suggest that hyperhomocysteinemia-enhanced brain damage is associated with increased autophagy and neuronal apoptosis in Apo E (显示 APOE 蛋白)(-/-) mice, in which downregulation of hes1 and hes5 (显示 HES5 蛋白) is involved.

  4. Although Hes5 (显示 HES5 蛋白)-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5 (显示 HES5 蛋白)-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis (显示 CISH 蛋白)-regulatory elements that regulate endogenous Hes5 (显示 HES5 蛋白) in the mouse lens and retina.

  5. there is a link between Dmrta2 (显示 DMRTA2 蛋白) modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development

  6. Hes-1 expression is maintained in neural progenitor territory throughout mouse neocortical development, a simple shift from Notch (显示 NOTCH1 蛋白)-independent to -dependent state makes it pleiotropic as the former maintains the neural stem cells in a non-dividing/slow-dividing state, whereas the latter is very much required for maintenance and proliferation of radial glial cells.

  7. inhibition of PTEN by Notch1 (显示 NOTCH1 蛋白)/Hes1 in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis in diabetic nephropathy

  8. this paper shows the critical role of the Notch1 (显示 NOTCH1 蛋白)-Hes1 signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation

  9. results suggest that SCF (显示 KITLG 蛋白)(FBXL14 (显示 FBXL14 蛋白)) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process

  10. Notch (显示 NOTCH1 蛋白) signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch (显示 NOTCH1 蛋白).

Pig (Porcine) Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. study identified nucleolar complex protein 3 homolog(FAD24 (显示 NOC3L 蛋白)) as a novel downstream target of transcription factor HES1 during adipogenesis

蛋白简介HES1

蛋白简介

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

Gene names and symbols associated with HES1

  • hes family bHLH transcription factor 1 (HES1)
  • hairy and enhancer of split 1 (Drosophila) (Hes1)
  • hes family bHLH transcription factor 1 (Hes1)
  • hes family bHLH transcription factor 4 (HES4)
  • hes family bHLH transcription factor 1 L homeolog (hes1.L)
  • bHLHb39 蛋白
  • c-hairy1A 蛋白
  • HAIRY1 蛋白
  • HES-1 蛋白
  • hes1 蛋白
  • HHL 蛋白
  • Hry 蛋白
  • Xhairy-1 蛋白
  • Xhairy1 蛋白
  • Xlh1 蛋白

Protein level used designations for HES1

class B basic helix-loop-helix protein 39 , hairy homolog , hairy-like protein , transcription factor HES-1 , RHL , C-HAIRY1 , c-hairy1B , Hairy and enhancer of split 1-A , Protein hairy-1 , hairy1 , transcription factor HES-1-A , hairy and enhancer of split 1 , LOW QUALITY PROTEIN: transcription factor HES-1

GENE ID SPECIES
3280 Homo sapiens
539547 Bos taurus
15205 Mus musculus
29577 Rattus norvegicus
395128 Gallus gallus
100499567 Sus scrofa
397813 Xenopus laevis
100734567 Cavia porcellus
101106560 Ovis aries musimon
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