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This protein belongs to the basic helix-loop-helix family of transcription factors. 再加上，我们可以发HES1 抗体 (166) 和 HES1 试剂盒 (16)和数多这个蛋白质的别的产品。
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HES1 is mono-ubiquitinated in a Fanconi anemia (显示 PALB2 蛋白) core complex-dependent manner.
Hes-1 knockdown promotes osteopontin (显示 SPP1 蛋白) expression in HUVECs and enhances OPN (显示 SPP1 蛋白)-induced angiogenesis.
Our results suggest that KN promotes goblet cell differentiation by regulating Wnt (显示 WNT2 蛋白), Notch (显示 NOTCH1 蛋白), and AhR (显示 AHR 蛋白) signals and expression of Hes1 and Hath1 (显示 ATOH1 蛋白).
In the present study, the authors reported the first observation of Hes1 oscillatory expression in human neural progenitor /stem cells, with an approximately 1.5 hour periodicity and a Hes1 protein half-life of about 17 (17.6 +/- 0.2) minutes. Human cytomegalovirus infection disrupts the Hes1 rhythm and down-regulates its expression.
A three-molecule score based on the expression of Notch (显示 NOTCH1 蛋白) pathway molecules: Jagged1 (显示 JAG1 蛋白), intracellular Notch1 (显示 NOTCH1 蛋白) (ICN1) and Hes1 (JIH score) to assess prognostic value in non-metastasis clear cell renal cell carcinoma (显示 MOK 蛋白) (ccRCC).
we demonstrate for the first time an essential role of HPV oncoprotein E6 that selectively overexpresses in CaCxSLCs and participates in maintenance of stem cell phenotype and stemness through upregulation of Hes1 while preponderance of E7 leads to differentiation.
IE1 is involved in Hes1 degradation by assembling a ubiquitination complex and promoting Hes1 ubiquitination as a potential E3 ubiquitin ligase (显示 MUL1 蛋白), followed by proteasomal degradation of Hes1.
Notch (显示 NOTCH1 蛋白) signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch (显示 NOTCH1 蛋白).
The phenotype was rescued by ectopic expression of miRNA182-5p in Delta182 cells. A bioinformatic analysis and Hes1 modulation data suggested that Hes1 could be a putative target of miRNA182-5p. A reciprocal relationship between miRNA182-5p and Hes1 was seen in the context of TK inhibition
These results suggest that HES1 promotes extracellular matrix protein expression and inhibits proliferative and migratory functions in the trabecular meshwork cells under oxidative stress, thereby providing a novel pathogenic mechanism underlying and a potential therapeutic target to primary open-angle glaucoma
Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia.
the results raise the possibility that HES1 or other genes that affect HES1 expression could be involved in the etiology of Ectopic pancreas .
These results suggest that hyperhomocysteinemia-enhanced brain damage is associated with increased autophagy and neuronal apoptosis in Apo E (显示 APOE 蛋白)(-/-) mice, in which downregulation of hes1 and hes5 (显示 HES5 蛋白) is involved.
Although Hes5 (显示 HES5 蛋白)-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5 (显示 HES5 蛋白)-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis (显示 CISH 蛋白)-regulatory elements that regulate endogenous Hes5 (显示 HES5 蛋白) in the mouse lens and retina.
there is a link between Dmrta2 (显示 DMRTA2 蛋白) modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development
Hes-1 expression is maintained in neural progenitor territory throughout mouse neocortical development, a simple shift from Notch (显示 NOTCH1 蛋白)-independent to -dependent state makes it pleiotropic as the former maintains the neural stem cells in a non-dividing/slow-dividing state, whereas the latter is very much required for maintenance and proliferation of radial glial cells.
inhibition of PTEN by Notch1 (显示 NOTCH1 蛋白)/Hes1 in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis in diabetic nephropathy
this paper shows the critical role of the Notch1 (显示 NOTCH1 蛋白)-Hes1 signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation
results suggest that SCF (显示 KITLG 蛋白)(FBXL14 (显示 FBXL14 蛋白)) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process
study identified nucleolar complex protein 3 homolog(FAD24 (显示 NOC3L 蛋白)) as a novel downstream target of transcription factor HES1 during adipogenesis
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
class B basic helix-loop-helix protein 39
, hairy homolog
, hairy-like protein
, transcription factor HES-1
, Hairy and enhancer of split 1-A
, Protein hairy-1
, transcription factor HES-1-A
, hairy and enhancer of split 1
, LOW QUALITY PROTEIN: transcription factor HES-1