Hes Family bHLH Transcription Factor 1 蛋白 (HES1)

This protein belongs to the basic helix-loop-helix family of transcription factors. 再加上,我们可以发HES1 抗体 (162)HES1 试剂盒 (15)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HES1 3280 Q14469
HES1 15205 P35428
HES1 29577 Q04666
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Showing 10 out of 15 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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小麦胚 GST tag 2 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) His tag Validation with Western Blot 50 μg Log in to see 11 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
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酵母菌 非洲爪蟾 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 Cow His tag   1 mg Log in to see 60至71个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
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酵母菌 小鸡 His tag   1 mg Log in to see 60至71个工作日
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大肠杆菌(E. Coli) His tag   10 μg Log in to see 5至8个工作日
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HES1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

更多Hes Family bHLH Transcription Factor 1 (HES1)互动伙伴

Human Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. High HES1 expression is associated with invasiveness and tumorigenicity of non-small cell lung cancer.

  2. High expression of Hes1 is associated with Colorectal Cancer.

  3. High HES1 expression is associated with pancreatic neoplasms.

  4. Depletion of HES1 increased cell death in response to endoplasmic reticulum stress in mouse and human cells, in a manner that depended on the pro-apoptotic gene growth arrest and DNA damage-inducible protein GADD34.

  5. The Sox17-Notch1-Hes1 pathway is critical for maintaining the undifferentiated state of IAHCs.

  6. MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1

  7. The results of this study demonstrate that HES1 is a specific downstream gene of NOTCH1 and that it contributes to SACC proliferation, apoptosis and metastasis.

  8. HES1 is mono-ubiquitinated in a Fanconi anemia core complex-dependent manner.

  9. Hes-1 knockdown promotes osteopontin expression in HUVECs and enhances OPN-induced angiogenesis.

  10. Our results suggest that KN promotes goblet cell differentiation by regulating Wnt, Notch, and AhR signals and expression of Hes1 and Hath1.

  11. In the present study, the authors reported the first observation of Hes1 oscillatory expression in human neural progenitor /stem cells, with an approximately 1.5 hour periodicity and a Hes1 protein half-life of about 17 (17.6 +/- 0.2) minutes. Human cytomegalovirus infection disrupts the Hes1 rhythm and down-regulates its expression.

  12. A three-molecule score based on the expression of Notch pathway molecules: Jagged1, intracellular Notch1 (ICN1) and Hes1 (JIH score) to assess prognostic value in non-metastasis clear cell renal cell carcinoma (ccRCC).

  13. we demonstrate for the first time an essential role of HPV oncoprotein E6 that selectively overexpresses in CaCxSLCs and participates in maintenance of stem cell phenotype and stemness through upregulation of Hes1 while preponderance of E7 leads to differentiation.

  14. IE1 is involved in Hes1 degradation by assembling a ubiquitination complex and promoting Hes1 ubiquitination as a potential E3 ubiquitin ligase, followed by proteasomal degradation of Hes1.

  15. Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.

  16. The phenotype was rescued by ectopic expression of miRNA182-5p in Delta182 cells. A bioinformatic analysis and Hes1 modulation data suggested that Hes1 could be a putative target of miRNA182-5p. A reciprocal relationship between miRNA182-5p and Hes1 was seen in the context of TK inhibition

  17. These results suggest that HES1 promotes extracellular matrix protein expression and inhibits proliferative and migratory functions in the trabecular meshwork cells under oxidative stress, thereby providing a novel pathogenic mechanism underlying and a potential therapeutic target to primary open-angle glaucoma

  18. Hes1 disruption leads to tumor regression without perturbing normal stem cell homeostasis, preclinically validating Hes1 as a cancer therapeutic target.

  19. Low Hes1 expression is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy.

  20. GPR146 has an antiviral role in fighting against viral infection, although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling.

Mouse (Murine) Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. Findings indicate that nuclear translocation of MSX-1, alone or in combination with HES-1, produce chondrocyte-like cells, and simultaneous activation of HES-1 and MSX-1 increases the generation of smooth muscle and neuronal cells.

  2. Olig2 represses expression of the Notch signaling pathway effectors Hes1 and Hes5

  3. Depletion of HES1 increased cell death in response to endoplasmic reticulum stress in mouse and human cells, in a manner that depended on the pro-apoptotic gene growth arrest and DNA damage-inducible protein GADD34.

  4. this paper shows that epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis

  5. miR-374b regulates the proliferation and differentiation of neural stem cells through targeting Hes1. Overexpression of Hes1 reverses the effect of miR-374b overexpression on neural stem cells differentiation.

  6. Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia.

  7. the results raise the possibility that HES1 or other genes that affect HES1 expression could be involved in the etiology of Ectopic pancreas .

  8. These results suggest that hyperhomocysteinemia-enhanced brain damage is associated with increased autophagy and neuronal apoptosis in Apo E(-/-) mice, in which downregulation of hes1 and hes5 is involved.

  9. Although Hes5-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis-regulatory elements that regulate endogenous Hes5 in the mouse lens and retina.

  10. there is a link between Dmrta2 modulation of Hes1 expression and the maintenance of neural progenitor cells during cortical development

  11. Hes-1 expression is maintained in neural progenitor territory throughout mouse neocortical development, a simple shift from Notch-independent to -dependent state makes it pleiotropic as the former maintains the neural stem cells in a non-dividing/slow-dividing state, whereas the latter is very much required for maintenance and proliferation of radial glial cells.

  12. inhibition of PTEN by Notch1/Hes1 in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis in diabetic nephropathy

  13. this paper shows the critical role of the Notch1-Hes1 signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation

  14. results suggest that SCF(FBXL14) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process

  15. Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.

  16. that HIF-1alpha but not HIF-2alpha is able to interact with either GA-binding protein alpha or GA-binding protein beta1

  17. Hes1 disruption leads to tumor regression without perturbing normal stem cell homeostasis, preclinically validating Hes1 as a cancer therapeutic target.

  18. Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.

  19. Hes1 plays a key role in acinar cell integrity and plasticity on cellular insults.

  20. the RBPjkappa-dependent Notch targets HES1 and HES5 suppress chondrogenesis and promote the onset of chondrocyte hypertrophy.

Pig (Porcine) Hes Family bHLH Transcription Factor 1 (HES1) interaction partners

  1. study identified nucleolar complex protein 3 homolog(FAD24) as a novel downstream target of transcription factor HES1 during adipogenesis

蛋白简介HES1

蛋白简介

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.

Gene names and symbols associated with HES1

  • hes family bHLH transcription factor 1 (HES1)
  • hairy and enhancer of split 1 (Drosophila) (Hes1)
  • hes family bHLH transcription factor 1 (Hes1)
  • hes family bHLH transcription factor 4 (HES4)
  • hes family bHLH transcription factor 1 L homeolog (hes1.L)
  • bHLHb39 蛋白
  • c-hairy1A 蛋白
  • HAIRY1 蛋白
  • HES-1 蛋白
  • hes1 蛋白
  • HHL 蛋白
  • Hry 蛋白
  • Xhairy-1 蛋白
  • Xhairy1 蛋白
  • Xlh1 蛋白

Protein level used designations for HES1

class B basic helix-loop-helix protein 39 , hairy homolog , hairy-like protein , transcription factor HES-1 , RHL , C-HAIRY1 , c-hairy1B , Hairy and enhancer of split 1-A , Protein hairy-1 , hairy1 , transcription factor HES-1-A , hairy and enhancer of split 1 , LOW QUALITY PROTEIN: transcription factor HES-1

GENE ID SPECIES
3280 Homo sapiens
539547 Bos taurus
15205 Mus musculus
29577 Rattus norvegicus
395128 Gallus gallus
100499567 Sus scrofa
397813 Xenopus laevis
100734567 Cavia porcellus
101106560 Ovis aries musimon
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