Hepatic Leukemia Factor 蛋白 (HLF)

HLF encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. 再加上,我们可以发HLF 抗体 (46)HLF 试剂盒 (6)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
HLF 217082 Q8BW74
HLF 3131 Q16534
HLF 690286  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$331.20
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大肠杆菌(E. Coli) His tag 50 μg Log in to see 15至19个工作日
$953.85
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
$2,781.17
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HLF 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , ,
,
Rat (Rattus)

更多Hepatic Leukemia Factor (HLF)互动伙伴

Mouse (Murine) Hepatic Leukemia Factor (HLF) interaction partners

  1. HLF-deficient hematopoietic stem cells display loss of quiescence and increased sensitivity to chemotoxic insults.

  2. Results demonstrate that Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations and that modulation of the pyridoxine pathway can also influence phenotype severity

  3. Conditional expression of E2A (显示 TCF3 蛋白)-HLF induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.

  4. Data indicate that Meis homeobox 1 (MEIS1 (显示 MEIS1 蛋白)) is required for the maintenance of myeloid-lymphoid leukemia protein MLL (显示 MLL 蛋白)-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1 (显示 MEIS1 蛋白).

  5. we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor (显示 TEF 蛋白)/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure

  6. mice deficient for all three PAR (显示 AFG3L2 蛋白) bZip proteins (DBP (显示 GC 蛋白),HLF,& TEF (显示 TEF 蛋白)) are highly susceptible to generalized spontaneous and audiogenic epilepsies, frequently lethal. Pyridoxal kinase (显示 PDXK 蛋白) is a target gene of PAR (显示 AFG3L2 蛋白) bZip proteins in both liver and brain

  7. The HLF protein control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (显示 NR1I3 蛋白) (CAR).

  8. Data show that the clock knockout mice or mice devoid of dbp (显示 GC 蛋白)/hlf/tef (显示 TEF 蛋白) (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance.

Human Hepatic Leukemia Factor (HLF) interaction partners

  1. Poly (ADP-ribose) polymerase (显示 PARP1 蛋白) inhibitors selectively induce cytotoxicity in TCF3 (显示 TCF3 蛋白)-HLF (显示 EPAS1 蛋白)-positive leukemic cells.

  2. HLF-mediated miR-132 directly suppresses TTK expression, thus exerting inhibitory effects on cancer cell proliferation, metastasis and radioresistance.

  3. Drug response profiling of matched patient-derived xenografts revealed a distinct profile for TCF3 (显示 TCF3 蛋白)-HLF (显示 EPAS1 蛋白) ALL with resistance to conventional chemotherapeutics but sensitivity to glucocorticoids.

  4. ectopic expression of HLF (显示 EPAS1 蛋白), an established transcription factor that cycles with circadian rhythms, can recapitulate many features associated with circadian-dependent physiological variation.

  5. both Lmo2 (显示 LMO2 蛋白) and Bcl-2 (显示 BCL2 蛋白) are required for the action of E2A (显示 TCF3 蛋白)-HLF (显示 EPAS1 蛋白) in leukemogenesis

  6. E2A (显示 TCF3 蛋白)-HLF (显示 EPAS1 蛋白) promotes cell survival of t(17;19)- acute lymphoblastic leukemia cells by aberrantly up-regulating LMO2 (显示 LMO2 蛋白) expression

  7. Evidence pertaining to leukemogenesis by the well-characterized oncogenic fusion protein E2A (显示 TCF3 蛋白)-HLF (显示 EPAS1 蛋白) is reviewed and its mechanistic implications are considered.

  8. E2A-HLF induces annexin II by substituting for cytokines that activate downstream pathways of Ras

  9. The E2A (显示 TCF3 蛋白)-HLF (显示 EPAS1 蛋白)-mediated over-expression of ABCB1 (显示 ABCB1 蛋白) may play a role in the clinical phenotype of ALLs with a t(17;19), suggesting pharmacologic modulation of ABCB1 (显示 ABCB1 蛋白) activity as a rational therapeutic strategy for this chemotherapy resistant subtype of ALL.

  10. The patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: E2A (显示 TCF3 蛋白)/PBX1 (显示 PBX1 蛋白) and E2A (显示 TCF3 蛋白)/HLF (显示 EPAS1 蛋白).

蛋白简介HLF

蛋白简介

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene names and symbols associated with Hepatic Leukemia Factor 蛋白 (HLF)

  • HLF, PAR bZIP transcription factor (HLF)
  • hepatic leukemia factor (Hlf)
  • hepatic leukemia factor a (hlfa)
  • Hepatic leukemia factor (Bm1_18395)
  • Hepatic leukemia factor (hlf)
  • HLF, PAR bZIP transcription factor (Hlf)
  • DKFZp469P0721 蛋白
  • E230015K02Rik 蛋白
  • Hlf 蛋白
  • HLF1 蛋白
  • zgc:153035 蛋白

Protein level used designations for Hepatic Leukemia Factor 蛋白 (HLF)

hepatic leukemia factor , hepatic leukemia factor 1 , zhlf1 , Hepatic leukemia factor

GENE ID SPECIES
706623 Macaca mulatta
516069 Bos taurus
217082 Mus musculus
100192429 Ovis aries
100171535 Pongo abelii
593063 Strongylocentrotus purpuratus
417395 Gallus gallus
455140 Pan troglodytes
3131 Homo sapiens
768192 Danio rerio
6098588 Brugia malayi
100380463 Salmo salar
100724740 Cavia porcellus
690286 Rattus norvegicus
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