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The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. 再加上，我们可以发Hemoglobin Alpha, Adult Chain 1 蛋白 (122) 和 Hemoglobin Alpha, Adult Chain 1 试剂盒 (1)和数多这个蛋白质的别的产品。
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Human Polyclonal HBA-A1 Primary Antibody for ChIP, ELISA - ABIN258357
Chen, Mclean, Thomas, Anderson, Sparling: Point mutations in HpuB enable gonococcal HpuA deletion mutants to grow on hemoglobin. in Journal of bacteriology 2001
Show all 10 Pubmed References
identify a novel sequence on Hb alpha that is important for Hb alpha/eNOS (显示 NOS3 抗体) complex formation and is critical for nitric oxide signaling at myoendothelial junctions
The human locus establishes prominent sites of Polycomb (显示 CBX2 抗体) complex recruitment in pluripotent stem cells, whereas the corresponding mouse locus does not.
The objective of this study was to test whether amino acid differences among triplicated alpha-globin paralogs are attributable to a relaxation of purifying selection or to a history of positive selection.
It is suggested that the higher expression of hemoglobin (显示 HBB 抗体) alpha1 in the brain may be associated with ECM (显示 MMRN1 抗体) and could be a source of excess heme, a molecule that is considered to trigger the pathogenesis of cerebral malaria.
These data suggest that CP2b (显示 CYP27B1 抗体) potentiate erythroid cell-specific alpha-globin expression by recruiting CP2c into the nucleus.
In this study, a novel promoter mutation of -72 (T-->A) within the conserved CCAAT box of beta-globin (显示 HBB 抗体) gene has been identified in heterozygous state. The proband and his two relatives carrying the same mutation showed almost normal mean corpuscular volume (MCV) and mean corpuscular hemoglobin (显示 HBB 抗体) (MCH (显示 PMCH 抗体)) level and slightly elevated HbA2 (显示 HBa2 抗体).
Carriers of Hb Nanning are asymptomatic and could be missed by screening based on MCV and MCH (显示 PMCH 抗体) cutoffs of <80.0 fL and <27.0 pg, respectively. Both carriers of the mutation in the study have MCV and MCH (显示 PMCH 抗体) values that are 2 standard deviations (SDs (显示 SDS 抗体)) below normal, as would be predicted for an alpha+-thal.
Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF (显示 VWF 抗体)) or type I collagen under shear stresses.
Hb Adana mutation was preferentially present in the alpha2-globin genes in Malays compared to the other ethnicities in Malaysia.
Seven novel nondeletional alpha-thalassemia mutations localized on the alpha2-globin gene in the heterozygous state were identified
Gene frequency for HBA2 (显示 HBa2 抗体):c.301-24delGinsCTCGGCCC carriers among the Chinese population in Guangxi.
Hemoglobin Constant Spring mutation in Southeast Asians with thalassemia.
We report herein for the first time the description of HbA2 (显示 HBa2 抗体)' in the Tunisian population.
In maturing RBC (显示 CACNA1C 抗体) progenitors AHSP (显示 aHSP 抗体) bind to free alpha-globin (显示 HBA1 抗体) chains to increase the HbA (显示 SCN2A 抗体) production. (Review)
Two mutations detected the -a(3,7) single gene deletion found in 75% of cases and the nongene deletion a2 IVS1 [-5nt (显示 ACPP 抗体)] in the remaining samples
Data indicate that on incubating hemoglobin with glyoxal for 0-20 days, advanced glycation end products (AGEs) were detected on day 20.
Residues 33-61a of hemoglobin alpha-chain from cattle tick gut (显示 GUSB 抗体) exhibit nonconventional conformation for an antimicrobial peptide (显示 cAMP 抗体), bound to sodium dodecyl sulfate micelles. The peptide is able to disrupt the bacterial membrane of Micrococcus luteus A270.
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin\; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1\; some nondeletion alpha thalassemias have also been reported.
, globin, alpha 1
, hemoglobin alpha chain
, hemoglobin subunit alpha
, alpha 1 globin
, alpha globin 1
, haemaglobin alpha 1
, Hemoglobin alpha chain