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Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. 再加上，我们可以发HSP90AA2 抗体 (235)和数多这个蛋白质的别的产品。
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Human HSP90AA2 Protein expressed in Escherichia coli (E. coli) - ABIN1686664
Arlander, Eapen, Vroman, McDonald, Toft, Karnitz: Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress. in The Journal of biological chemistry 2003
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The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models
Data indicate that heat shock protein 90alpha (Hsp90alpha1) function in myosin thick filament organization is potentially regulated by post-translational modification (PTM) involving phosphorylation and acetylation.
The chaperone proteins Ahsa1 (显示 AHSA1 蛋白) and Hsp90 (显示 HSP90 蛋白) promote severe craniofacial phenotypes in zebrafish model of HDR (显示 GATA3 蛋白) syndrome.
Perturbation of the HSP70 (显示 HSPA1A 蛋白)-HSP90 (显示 HSP90 蛋白) heat-shock protein axis stimulates degradation of endothelial VEGFR2 (显示 KDR 蛋白).
studies indicate that the hsp90alpha1 mutant phenotype is not simply due to disruption of myosin folding and assembly, suggesting that Hsp90alpha1 may play a role in the assembly and organization of other sarcomeric structures
Mild perturbation of Hsp90 (显示 HSP90 蛋白) function at critical developmental stages may underpin the variable penetrance and expressivity of many developmental anomalies where the interaction between genotype and environment plays a major role.
Steif/Unc-45b (显示 UNC45B 蛋白) interacts with the chaperone Hsp90a (显示 HSP90AA1 蛋白) in vitro. The two genes are co-expressed in the skeletal musculature.
Embryonic heat shock reveals latent hsp90 (显示 HSP90 蛋白) translation in zebrafish.
Loss of Hsp90a (显示 HSP90AA1 蛋白) function leads to the downregulation of genes encoding sarcomeric proteins and upregulation of hsp90a (显示 HSP90AA1 蛋白) and several other genes encoding proteins that may act with Hsp90a (显示 HSP90AA1 蛋白) during sarcomere assembly.
In response to stress or damage to the myofiber, Unc45b and Hsp90a dissociate from the Z line and transiently associate with myosin.
Knocking out Hsp90beta (显示 HSP90AB1 蛋白) leads to tumour cell death. Extracellular supplementation with recombinant Hsp90alpha, but not Hsp90beta (显示 HSP90AB1 蛋白), protein recovers tumourigenicity of the Hsp90alpha-knockout cells. Sequential mutagenesis identifies two evolutionarily conserved lysine residues, lys (显示 LYZ 蛋白)-270 and lys (显示 LYZ 蛋白)-277, in the Hsp90alpha subfamily that determine the extracellular Hsp90alpha function.
We revealed that Hsp90A (显示 HSP90AA1 蛋白) and Hsp90B (显示 HSP90AB1 蛋白) are partly colocalized with heparan sulfate proteoglycans (HSPGs) on the cell surface and that this colocalization was sensitive to heparin.
Heat shock protein 90 stimulates rat mesenchymal stem cell migration via PI3K/Akt and ERK1/2 pathways
Studied the serum prolactin (显示 PRL 蛋白), cortisol, and ACTH (显示 POMC 蛋白) stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects.
These results indicate that cytoplasmic HSP90alpha may serve as a biomarker for perineural invasion in pancreatic cancer
Increased expression of nucleated RBC (显示 CACNA1C 蛋白), HSP90alpha and corresponding decreased expression of HO-2 (显示 HMOX2 蛋白) in such hypoxic condition may play a protective role; to prevent cord blood RBC (显示 CACNA1C 蛋白) against stress induced damage during preeclampsia.
STAT5b (显示 STAT5B 蛋白) pathway regulates Hsp90alpha expression under hypoxic conditions
HSP90alpha was an IMH-2 epitope-associated protein. Tumor HSP90alpha overexpression was correlated with the metastasis and poor prognosis of colorectal cancer patients.
extracellular HSP90alpha transactivates EGFR/ErbB1 (显示 EGFR 蛋白) through TLR4 (显示 TLR4 蛋白) and a PKCdelta (显示 PKCd 蛋白)/c-Src (显示 SRC 蛋白) pathway, which induces ATP release and cytosolic Ca(2 (显示 CA2 蛋白)+) increase and finally favors glioblastoma cell migration.
High gene expression of Hsp90 alpha (显示 HSP90AA1 蛋白) is associated with leukemia.
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Plays a key role in slow and fast muscle development in the embryo. Plays a role in myosin expression and assembly.
, heat shock protein 90-alpha 1
, heat shock protein HSP 90-alpha 1