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The product of HSF1 is a heat-shock transcription factor. 再加上，我们可以发HSF1 抗体 (498) 和 HSF1 蛋白 (14)和数多这个蛋白质的别的产品。
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These functions of HPK-1/HSF-1 undergo rapid down-regulation once animals reach reproductive maturity. We show that HPK-1 fortifies proteostasis and extends longevity by an additional independent mechanism: induction of autophagy.
Diminution in phenotypic variation for both gene expression and life span at 25 degrees C may be a consequence of low level hsf-1-dependent expression of HSP-16.2 and other chaperones at the higher temperature.
We demonstrate that while DAF-16/FOXO is dispensable, the age-dependent suppression of cilia phenotypes in IFT mutants requires cell-autonomous functions of the HSF1 heat shock factor and the Hsp90 chaperone
HSF-1 is a codeterminant of both alcohol and nicotine sensitivity in C. elegans and that this phenotype requires the small HSP, HSP-16.48. HSP-16.48 function in drug sensitivity is unrelated to a chaperone action during the heat shock stress response.
Heat-stress-enhanced ascaroside production appears to be mediated at least in part by HSF-1, which seems to be important in adaptation strategies for coping with heat stress in this nematode.
FUdR treatment can modulate the HSR and proteostasis, and should be used with caution when used to inhibit reproduction.
Excitation of the AFD thermosensory neurons is sufficient to activate HSF1 in another cell, even in the absence of temperature increase. Excitation of the AFD thermosensory neurons enhances serotonin release.
hsf-1 RNAi suppressed the restoration of thrashing reduced by heat stress. In contrast, hsf-1 knockdown cancelled prevention of movement reduction in a daf-2 mutant, but didn't suppress thrashing restoration in daf-2 mutant.
we engaged C. elegans mutants and identified that the p38 MAPK signaling, insulin (显示 INS ELISA试剂盒)/IGF-1 (显示 IGF1 ELISA试剂盒) signaling (IIS), and HSF-1 play pivotal roles in the WCESP-mediated host immune response
HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging. Overexpression of pat-10 increased actin filament stability, thermotolerance, and longevity, indicating that in addition to chaperone regulation, HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging.
HSF1 activity is decreased in fibrotic hearts. HSF1 inhibits phosphorylation and nuclear distribution of Smad3 (显示 SMAD3 ELISA试剂盒) via direct binding to Smad3 (显示 SMAD3 ELISA试剂盒). Active Smad3 (显示 SMAD3 ELISA试剂盒) blocks the anti-fibrotic effect of HSF1.
the expression level of NFATc2 (显示 NFAT1 ELISA试剂盒), miR (显示 MLXIP ELISA试剂盒)-208b and miR (显示 MLXIP ELISA试剂盒)-499 suggested that these responses were suppressed in HSF1-null mice
identify 4 huntingtin (显示 HTT ELISA试剂盒)-targeting miRNAs viz. miR (显示 MLXIP ELISA试剂盒)-125b, miR (显示 MLXIP ELISA试剂盒)-146a, miR (显示 MLXIP ELISA试剂盒)-150 and miR (显示 MLXIP ELISA试剂盒)-214 as candidate miRNAs responsible for observed inhibitory effect of HSF1 on huntingtin (显示 HTT ELISA试剂盒) expression.
HSF1 plays an important role in the occurrence of UVR-B-induced cataracts, possibly via regulation of HSPs such as HSP25 (显示 HSPB1 ELISA试剂盒).
Targeted deletion of HSF1 results in changes of locomotor function associated with changes in cerebellar calbindin (显示 CALB1 ELISA试剂盒) protein levels. These findings suggest a role of HSF1 in regular Purkinje cell calcium homeostasis.
this study shows that HSF1 overexpression protects against TDP-43 (显示 TARDBP ELISA试剂盒) pathology by upregulation of chaperones, especially HSP70 (显示 HSP70 ELISA试剂盒), rather than enhancing autophagy
Acetylation of the protein triggers TDP-43 (显示 TARDBP ELISA试剂盒) pathology in cultured cells and mouse skeletal muscle, which can be cleared through an HSF1-dependent chaperone mechanism that disaggregates the protein.
These findings provide insight into the role of HSF1 in Leydig cell steroidogenesis, suggesting that it maintains cholesterol transport by recovering StAR under chronic heat stress.
In mammalian cell lines, only heat shock-induced but not basal expression of chaperones is dependent on the mammalian Hsf1 homolog.
Upregulating HSF1 relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (显示 DDIT3 ELISA试剂盒) and increasing HSP70 (显示 HSP70 ELISA试剂盒) a5 (BiP/GRP78 (显示 HSPA5 ELISA试剂盒)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 being one likely key player in both systems.
Our findings show that miR-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of Hepatocellular carcinoma (HCC) by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR-487a as a potential prognostic marker or a potential therapeutic target against HCC.
Results suggest for targeting heat shock factor 1 (HSF1)activation in combination with bortezomib to enhance multiple myeloma treatment efficacy.
MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction.
We found that HSF1 activation mediated by 1,4-NQ upregulated downstream genes, such as HSPA6 (显示 HSPA6 ELISA试剂盒). The results suggest that activation of the HSP90 (显示 HSP90 ELISA试剂盒)-HSF1 signal transduction pathway mediated by 1,4-NQ protects cells against 1,4-NQ and that per/polysulfides can diminish the reactivity of 1,4-NQ by forming sulfur adducts.
casein kinase 1 (显示 CSNK1A1 ELISA试剂盒) phosphorylates the SQSTM1 (显示 SQSTM1 ELISA试剂盒) S349 residue when harmful proteins accumulate under HSF1 stress
Evidence for the essential function of HSF1 in the transcriptional activation of TERRA and in telomere protection upon stress.
Low glucose culture hampered typical epithelial-mesenchymal transition-like morphological change, "cadherin switching," and cell migration of hepatocellular carcinoma cells through inducing persistent down-regulation of HSF1, resulting in direct inhibition of snail1 (显示 SNAI1 ELISA试剂盒) expression.
piR (显示 PIR ELISA试剂盒)-823 increased the transcriptional activity of HSF1, the common transcription factor of HSPs, by binding to HSF1 and promoting its phosphorylation at Ser326.
As the 4693-T mutation caused the disruption of microRNA target binding (resulting in the relief of the transcriptional repression), the HSF1 gene is useful in dairy cattle thermal tolerant breeding.
HSF1 is a key trans-acting factor for counteracting transgene promoter silencing in Chlamydomonas.
Data show that activated HSF1 and CRR1 transcription factors mediate the acetylation of histones H3/4, nucleosome eviction, remodeling of the H3K4 mono- and dimethylation marks, and transcription initiation/elongation.
data suggest that HSF1 is a key regulator of the stress response in Chlamydomonas
Data suggest that myocardial HSF1 and HSP70 (显示 HSP70 ELISA试剂盒) (70 kDa heat-shock protein (显示 HSPA9 ELISA试剂盒)) can be up-regulated by dietary factors (here, antioxidant taurine as a dietary supplement administered to counteract effects of atherogenic diet).
The results indicate that Heat shock protein 70 (Hsp70) mediates distinct stress-related functions in different tissues during transportation. Heat shock factor-1 (HSF-1) levels were reduced at 1 and 4 h only in the hearts of transported pigs.
The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models
data suggest that HSF1 is involved in regulating constitutive lens specific expression of hsp70 (显示 HSPA1A ELISA试剂盒) in the embryonic zebrafish
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.
heat shock factor protein
, heat shock transcription factor
, Heat Shock Factor family member (hsf-1)
, HSF 1
, HSTF 1
, heat shock factor protein 1
, heat shock transcription factor 1