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E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. 再加上，我们可以发HACE1 抗体 (28) 和 HACE1 蛋白 (4)和数多这个蛋白质的别的产品。
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Results indicated that HACE1 rs9404576 polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population.
3-deazaneplanocin A treatment increased HACE1 gene expression which was further increased by the addition of trichostatine A (TSA (显示 PRDX2 ELISA试剂盒)), a promising therapeutic compound for the treatment of human B-Lymphoma
Mechanistic studies showed that HACE1 exerts its inhibitory role on virus-induced signaling by disrupting the MAVS (显示 MAVS ELISA试剂盒)-TRAF3 (显示 TRAF3 ELISA试剂盒) complex.
HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin
Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival.
HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains.
Biallelic loss-of-function mutations in HACE1 are associated with an autosomal recessive neurodevelopmental syndrome.
supports a critical role for HACE1 in breast cancer progression and identifies patients that may benefit from Rac (显示 AKT1 ELISA试剂盒)-targeted therapies
contrary to previous report, overexpression of HACE1 by transduction of recombinant protein did not affect proliferation or survival of NKTCL cell lines. We therefore conclude that HACE1 is not directly involved in NKTCL pathophysiology
HACE1-OPTN (显示 OPTN ELISA试剂盒) axis synergistically suppresses growth and tumorigenicity of lung cancer cells.
HACE1 controls TNF-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1 (显示 TNFRSF1A ELISA试剂盒)-RIP3 kinase-necroptosis pathway.
Increased reactive oxygen species (ROS (显示 ROS1 ELISA试剂盒)) production due to Hace1 loss leads to glutamine (显示 GFPT1 ELISA试剂盒) addiction as a mechanism to cope with increased ROS (显示 ROS1 ELISA试剂盒)-induced oxidative stress.
Data indicate that HECT E3 ubiquitin ligase HACE1 deficiency accelerates pressure overload-induced heart failure.
Hace1 controls ROS (显示 ROS1 ELISA试剂盒) generation of vertebrate Rac1-dependent NADPH oxidase (显示 NOX1 ELISA试剂盒) complexes.
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB (By similarity).
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
, E3 ubiquitin-protein ligase HACE1
, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1
, E3 ubiquitin-protein ligase HACE1-like
, e3 ubiquitin-protein ligase HACE1-like