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The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. 再加上，我们可以发GFER 抗体 (82) 和 GFER 试剂盒 (19)和数多这个蛋白质的别的产品。
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WWC2 functions as a tumor suppressor by negatively regulating the Hippo signaling pathway and may serve as a prognostic marker in hepatocellular carcinoma.
the results of this study demonstrated that targeted inhibition of the ALR expression in Jurkat cells triggered cell growth inhibition and sensitized cells to VCR via promoting apoptosis and regulating the cell cycle.
IKBKE (显示 IKBKE 蛋白) plays a pivotal role in regulating cell proliferation, invasion and epithelial-mesenchymal transition of malignant glioma cells in vitro and in vivo by impacting on the Hippo pathway.
we found 2 additional patients carrying compound heterozygous variants in GFER. Reverse phenotyping confirmed the phenotypical similarities between the 4 patients. Together with the first literature reports, the review of these 8 cases from 4 unrelated families enables us to better describe this apparently homogeneous disorder, with the clinical and biological stigmata of mitochondrial disease
ese findings collectively indicate that ALR negatively regulates the autophagy process through an association with the AMPK (显示 PRKAA1 蛋白)/mTOR (显示 FRAP1 蛋白) signaling pathway. Autophagy inhibit apoptosis and play a protective role under conditions of oxidative stress.
HPO interaction with MOB1 (显示 MOBKL3 蛋白) is not essential for development and tissue growth control.
Overexpression of augmenter of liver regeneration (ALR) in liver cancer was studied and found to improve sensitivity to antitumor drugs by increasing the retention of intracellular drugs, at least partly through the modulation of the ABCB1 (显示 ABCB1 蛋白) and ABCG2 signaling pathway.
ALR protects steatotic hepatocytes from ischemia reperfusion injury by attenuating oxidative stress and mitochondrial dysfunction.
Our results show that MARK4 (显示 MARK4 蛋白) acts as a negative regulator of the Hippo kinase cassette to promote YAP (显示 YAP1 蛋白)/TAZ (显示 TAZ 蛋白) activity and that loss of MARK4 (显示 MARK4 蛋白) restrains the tumorigenic properties of breast cancer cells.
ALR, dependent on its localization, changes the acute-phase response (APR (显示 LRP1 蛋白)) at least in part, by modifying STAT3 (显示 STAT3 蛋白) activation; dual signaling of ALR suggests that ALR is pivotal for the regulation of APR (显示 LRP1 蛋白), a crucial event in liver injury and regeneration
The exogenous expression of hepatic stimulator substance (HSS (显示 PANK2 蛋白) was renamed augmenter of liver regeneration ALR) protected the liver from steatosis in mice with nonalcoholic steatohepatitis.
this study shows that ALR can weaken ConA-induced hepatitis
ALR is apparently required to ensure appropriate liver regeneration following PH in mice, and deletion of the ALR gene may delay liver regeneration in part due to impaired mitochondrial biogenesis.
ALR can protect mice against acute liver injury by up-regulating the expression of regulatory T cells.
From weeks 2-4 after birth, levels of steatosis and apoptosis decreased in ALR-L-KO mice, and numbers of ALR-expressing cells increased, along with ATP level
As a mechanism, we suggest a direct protective effect of ALR on apoptotic and necrotic death of hepatocytes and an attenuation of inflammatory cell influx into the postischemic tissue.
ALR may serve as a potential diagnostic marker of hepatocellular stress and/or acute inflammatory conditions.
Growth factor erv1-like (Gfer) inhibits the COP9 (显示 COPS8 蛋白) signalosome subunit jun activation-domain binding protein 1 (Jab1 (显示 COPS5 蛋白))-mediated degradation of the cyclin-dependent kinase inhibitor p27(kip1 (显示 CDKN1B 蛋白)) to restrict proliferation of hematopoietic stem cells.
Gfer plays an essential pro-survival role in the maintenance of murine embryonic stem cell pluripotency by preserving the structural and functional integrity of their mitochondria, through modulation of the key mitochondrial fission factor (显示 MFF 蛋白) Drp1 (显示 CRMP1 蛋白).
Growth factor erv1-like modulates Drp1 (显示 CRMP1 蛋白) to preserve mitochondrial dynamics and function in mouse embryonic stem cells
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene.
, FAD-linked sulfhydryl oxidase ALR
, erv1-like growth factor
, hepatic regenerative stimulation substance
, hepatopoietin protein
, augmenter of liver regeneration
, growth factor, erv1 homolog
, growth factor, erv1-like (augmenter of liver regeneration)
, growth factor, augmenter of liver regeneration
, growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)