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Bone morphogenetic proteins (e.g., BMP9\; MIM 605120) are members of the transforming growth factor-beta (see TGFB1\; MIM 190180) superfamily and regulate tissue differentiation and maintenance. 再加上，我们可以发GDF15 抗体 (314) 和 GDF15 蛋白 (34)和数多这个蛋白质的别的产品。
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Human GDF15 ELISA Kit for Sandwich ELISA - ABIN624984
Barderas, Mendes, Torres, Bartolomé, López-Lucendo, Villar-Vázquez, Peláez-García, Fuente, Bonilla, Casal: In-depth characterization of the secretome of colorectal cancer metastatic cells identifies key proteins in cell adhesion, migration, and invasion. in Molecular & cellular proteomics : MCP 2013
Show all 9 Pubmed References
Human GDF15 ELISA Kit for Sandwich ELISA - ABIN365728
Jiang, Yu, Wang, Tang, Guo, Jiao: Regulation of hepcidin through GDF-15 in cancer-related anemia. in Clinica chimica acta; international journal of clinical chemistry 2014
Human GDF15 ELISA Kit for Sandwich ELISA - ABIN415137
Sun, Huang, Phillips, Luo, Zhu, Shi, Li: Growth differentiation factor 15 and coronary collateral formation. in Clinical cardiology 2010
Data show that serum growth differentiation factor 15 (GDF15)levels were significantly higher in subjects with thyroid nodules compared with nodule negative subjects, and this was influenced by age.
Findings suggest that GDF15 induces tumor sphere formation through GDF15-ERK1/2 (显示 MAPK1/3 ELISA试剂盒)-GDF15 circuits, leading to maintenance of GDF15high cancer stem-like cells.
These authors demonstrate that blocking cardiomyocyte production of GDF15 normalizes circulating GDF15 level and restores liver growth hormone (显示 GH1 ELISA试剂盒) signaling, establishing GDF15 as a bona fide heart-derived hormone that regulates pediatric body growth.
Authors demonstrated that GDF15 contributed to radioresistance of HNC (显示 MMP8 ELISA试剂盒), as determined by both gain- and lost-of-functional experiments. Authors further showed that GDF15 facilitated the conversion of cancer stemness, as assessed by the promotion of CD44 (显示 CD44 ELISA试剂盒)+ and ALDH1 (显示 ALDH1A1 ELISA试剂盒)+ cell populations and spheroid cell formation.
this study, for the first time, demonstrates that GDF15 is a promising target for preventing cold I/R injury in heart transplantation. This study also shows that the resultant protective effects are mediated by the Foxo3 and NFkappaB signaling pathways
High circulating GDF-15 levels are predictive of secondary cardiovascular events in women but not in men with carotid atherosclerosis.
In patients with chronic obstructive pulmonary disease, high levels of GDF15 were independently associated with a higher yearly rate of exacerbations, higher mortality and increased decline in both FEV1 and FVC.
Data suggested NAG-1 protein as a crucial mediator of epithelial ovarian cancer (EOC) progression and resistance to the standard first-line chemotherapy against EOC, particularly in MyD88 (显示 MYD88 ELISA试剂盒)-positive ovarian cancer stem-like cells.
The GDF-15 gene rs1804826G/T polymorphism and sGDF-15 levels are associated with ischemic stroke in the Chinese population.
NSAID-activated gene 1 (NAG-1) has been assessed for its involvement in cellular integrity and pathogenesis in mucosal inflammation and carcinogenesis. [review]
isolating GFRAL as the receptor for GDF15-induced anorexia and weight loss, the identification of a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress; findings provide opportunities to develop therapeutic agents for the treatment of disorders with altered energy demand
These data suggest that GDF15 is required for IL-13 (显示 IL13 ELISA试剂盒)-induced improvement of glucose intolerance in mice fed an HFD.
HIF-1alpha (显示 HIF1A ELISA试剂盒) and GDF15 expression are inversely related under normoxia and hyperoxia.
This is the first study defining the role of Mic-1/Gdf15 in a number of behavioural domains.
epithelial restitution was promoted by enhanced NAG-1 expression and subsequent enterocyte locomotion during the early wound-healing process
both GDF-15 and TGF-beta1 (显示 TGFB1 ELISA试剂盒) counteract chemokine (显示 CCL1 ELISA试剂盒)-induced integrin activation on neutrophils via the ALK-5 (显示 TGFBR1 ELISA试剂盒)/TGF-betaRII heterodimer.
GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin (显示 INS ELISA试剂盒) resistance.
The aim of this study was to identify the role of endogenous Gdf-15 in the MPTP (显示 PTPN2 ELISA试剂盒) (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease (PD) by comparing Gdf-15 (+/+) and Gdf-15 (-/-) mice.
The results of this study indicated the importance of Gdf-15 in promoting survival of DAergic neurons and regulating the inflammatory response post 6-OHDA lesion.
endogenous Growth/differentiation factor-15 is beneficial for axon regeneration following sciatic nerve crush
Bone morphogenetic proteins (e.g., BMP9\; MIM 605120) are members of the transforming growth factor-beta (see TGFB1\; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.
growth differentiation factor 15
, NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
, NSAID-activated gene 1 protein
, NSAID-regulated gene 1 protein
, growth/differentiation factor 15
, macrophage inhibitory cytokine 1
, placental TGF-beta
, placental bone morphogenetic protein
, prostate differentiation factor
, macrophage inhibiting cytokine-1