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The protein encoded by GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. 再加上，我们可以发GDF11 抗体 (54) 和 GDF11 蛋白 (23)和数多这个蛋白质的别的产品。
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Mouse (Murine) GDF11 ELISA Kit for Sandwich ELISA - ABIN425326
Wang, Shen, Li, Chen, Wang, Qin, Zhou, Peng, Feng, Li, Liang: Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice. in Oncotarget 2015
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Rat (Rattus) GDF11 ELISA Kit for Sandwich ELISA - ABIN840607
Bickford, Kaneko, Grimmig, Pappas, Small, Sanberg, Sanberg, Tan, Douglas Shytle: Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells. in Age (Dordrecht, Netherlands) 2015
Tumor-suppressor inactivation of GDF11 occurs by precursor sequestration in triple-negative breast cancer
These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8 (显示 MSTN ELISA试剂盒); however, the biological consequences of these differences remain to be determined.
In elderly Chinese women, osteoporosis risk was significantly increased with increases in GDF11 serum levels.
A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble
MSTN (显示 MSTN ELISA试剂盒), but not GDF11, declines in healthy men throughout aging.
GDF11 is highly concentrated in human platelets.
The crystal structure of GDF11 was determined to a resolution of 1.50 A.
GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review.
GDF11 inhibits rather than helps muscle regeneration.
Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.
Our results showed that GDF11 inhibited osteoblastic differentiation of bone marrow mesenchymal stem cells in vitro and had no effect on osteoclast differentiation or bone resorption
In conclusion, our findings show that GDF11 expression declines with age and the protective effects of ultrasound-targeted microbubble destruction-mediated delivery of GDF11 on the aged ischemic heart provide support for the classification of GDF11 as an anti-aging factor
we found that myostatin (显示 MSTN ELISA试剂盒) forms a complex with LTBP4 (显示 LTBP4 ELISA试剂盒) and that overexpression of LTBP4 (显示 LTBP4 ELISA试剂盒) led to a decrease in myostatin (显示 MSTN ELISA试剂盒) levels. LTBP4 (显示 LTBP4 ELISA试剂盒) also interacted with TGFbeta (显示 TGFB1 ELISA试剂盒) and GDF11, a protein highly related to myostatin (显示 MSTN ELISA试剂盒). These data identify LTBP4 (显示 LTBP4 ELISA试剂盒) as a multi-TGFbeta (显示 TGFB1 ELISA试剂盒) family ligand binding protein with the capacity to modify muscle disease through overexpression
Circulating levels of GDF11/8 declines with age in mice (and sheep, horses and rats).
Data show that circulating myostatin (显示 MSTN ELISA试剂盒) levels decreased with age and estimates of growth differentiation factor 11 (GDF11) levels using myostatin (显示 MSTN ELISA试剂盒) null mice indicate that they were almost 500 times lower than those for myostatin (显示 MSTN ELISA试剂盒).
Two new studies demonstrate that GDF11 this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.
Therefore, we postulate that GDF (显示 GDF5 ELISA试剂盒)-11DeltaEx1 may act as a long non-coding RNA to regulate the transcription of canonical GDF-11 and/or other genes in skeletal muscle and other tissues
Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic mice.
GDF11 inhibited erythroid maturation in mice in vivo and ex vivo. Expression of GDF11 in erythroid precursors decreased progressively with maturation, suggesting an inhibitory role for GDF11 in late-stage erythroid differentiation.
Gdf11 stimulates expression of a Hoxd11/lacZ (显示 GLB1 ELISA试剂盒) transgene in the mouse embryo tailbud.
First non-mammalian growth/differentiation factor (GDF) 11-like homolog was cloned from zebrafish. Sequencing,phylogenetic analysis,tissue expression, and mRNA levels during embryonic development are reported.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
, bone morphogenetic protein 11
, growth/differentiation factor 11
, growth differentiation factor 11