Gremlin 2 蛋白 (GREM2)

GREM2 encodes a member of the BMP (bone morphogenic protein) antagonist family. 再加上,我们可以发Gremlin 2 抗体 (51)Gremlin 2 试剂盒 (12)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
大鼠 GREM2 GREM2 289264  
GREM2 23893 O88273
GREM2 64388 Q9H772
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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大肠杆菌(E. Coli) 非结合性   20 μg Log in to see 2至3个工作日
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GREM2 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , ,
, ,

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Zebrafish Gremlin 2 (GREM2) interaction partners

  1. Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development.

  2. Gremlin 2 regulates distinct roles of BMP and Endothelin 1 (显示 EDN1 蛋白) signaling in dorsoventral patterning of the facial skeleton.

  3. Prdc is expressed in the developing eyes and the first two pharyngeal arches, in the outer layers of the optic cup, in the arch mesenchyme expands stepwise to the remaining posterior arches, and in the somites and the the swim bladder.

Mouse (Murine) Gremlin 2 (GREM2) interaction partners

  1. Grem2 knockdown inhibited cardiomyocyte differentiation, and this effect was similar to that of Notch1 (显示 NOTCH1 蛋白) pathway inhibition in vitro. Grem2 enhances the protective effect of cardiac progenitor cells on heart function in a mouse model of myocardial infarction.

  2. Grem2 provides a molecular barrier that controls the extent of inflammatory cell infiltration by suppressing BMP2 (显示 BMP2 蛋白) after myocardial infarction.

  3. Grem2 expression is regulated during development and embryonic stem cell differentiation.

  4. PRDC binds heparin with high affinity and that heparin binding to PRDC interferes with BMP antagonism.

  5. We show that Tbx2 directly represses Grem1 in distal regions of the posterior limb mesenchyme allowing Bone morphogenetic protein (Bmp) signaling to abrogate Fgf4/9/17 expression in the overlying epithelium.

  6. Through a combination of biophysical and biochemical studies, the authors determined that PRDC forms biologically active dimers that potently inhibit BMP ligands.

  7. The differential regulation of Gremlin2 gene expressions by BMP2 (显示 BMP2 蛋白) may explain the critical function of these genes during osteoblast differentiation.

  8. ovarian PRDC expressed in granulosa cells could be involved in follicular development by antagonizing the actions of theca cell-derived Bone morphogenetic proteins

  9. We propose that PRDC might serve as a mediator to antagonize BMP-4 (显示 BMP4 蛋白) signaling by Wnt (显示 WNT2 蛋白).

  10. PRDC expression in osteoblasts suppresses differentiation and that reduction of PRDC expression promotes osteogenesis in vitro. PRDC is accordingly identified as a potential novel therapeutic target for the regulation of bone formation.

Human Gremlin 2 (GREM2) interaction partners

  1. Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes.

  2. The structure of Grem2-GDF5 (显示 GDF5 蛋白) complex has revealed a number of key findings for DAN-family mediated BMP2 (显示 BMP2 蛋白) inhibition.

  3. This study showed that si-Grem2 increased the BMP-2 (显示 BMP2 蛋白)-induced osteogenic differentiation of hBMSCs via the BMP-2 (显示 BMP2 蛋白)/Smad (显示 SMAD1 蛋白)/Runx2 (显示 RUNX2 蛋白) pathway.

  4. The present study shows that the Grem2 heparin/HS and BMP2 (显示 BMP2 蛋白)-binding epitopes are unique and independent, where the Grem2-BMP2 (显示 BMP2 蛋白) complex exhibits a significant increase in binding affinity toward heparin moieties that appear to be partially independent of the Grem2 heparin/HS-binding epitope.

  5. Gremlin 2 inhibits adipocyte differentiation through activation of Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling

  6. GREM2 variants have been identified in atrial fibrillation cohort studies, demonstrating abnormalities in cardiac excitation - supra ventricular tachycardia and atrial fibrillation.

  7. The minor allele of rs4454537 is significantly associated with low bone density at the total hip of southern Chinese people. Our study further suggests GREM2 as a novel susceptibility gene for osteoporosis.

  8. Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development.

  9. and that a genetic variant in the FMN2/GREM2 locus influences GREM2 expression in osteoblasts and thereby trabecular number and thickness as well as fracture risk.

蛋白简介Gremlin 2 (GREM2)

蛋白简介

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.

Gene names and symbols associated with Gremlin 2 蛋白 (GREM2)

  • gremlin 2, DAN family BMP antagonist (GREM2)
  • gremlin 2, DAN family BMP antagonist b (grem2b)
  • gremlin 2, cysteine knot superfamily (grem2)
  • gremlin 2, DAN family BMP antagonist (grem2)
  • gremlin 2, DAN family BMP antagonist (Grem2)
  • CKTSF1B2 蛋白
  • DAND3 蛋白
  • Gremlin2 蛋白
  • PRDC 蛋白
  • RGD1560008 蛋白
  • zgc:112207 蛋白

Protein level used designations for Gremlin 2 蛋白 (GREM2)

gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) , gremlin 2, cysteine knot superfamily, homolog , gremlin-2 , protein related to DAN and cerberus homolog , gremlin 2, cysteine knot superfamily , gremlin 2 homolog, cysteine knot superfamily , Gremlin1 , cysteine knot superfamily 1, BMP antagonist 2 , protein related to DAN and cerberus , DAN domain family member 3

GENE ID SPECIES
421507 Gallus gallus
469727 Pan troglodytes
490367 Canis lupus familiaris
550399 Danio rerio
100194915 Salmo salar
100528649 Ictalurus punctatus
289264 Rattus norvegicus
23893 Mus musculus
64388 Homo sapiens
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