Granzyme K (Granzyme 3, Tryptase II) 蛋白 (GZMK)

GZMK product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. 再加上,我们可以发Granzyme K (Granzyme 3, Tryptase II) 抗体 (84)Granzyme K (Granzyme 3, Tryptase II) 试剂盒 (31)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GZMK 14945 O35205
GZMK 29165 P49864
GZMK 3003 P49863
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Showing 10 out of 14 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至18个工作日
$512.00
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Baculovirus infected Insect Cells His tag 50 μg Log in to see 13至16个工作日
$400.00
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 13至16个工作日
$400.00
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小麦胚 GST tag 2 μg Log in to see 11至12个工作日
$230.67
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
$2,588.67
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大肠杆菌(E. Coli) 小鼠 His tag 100 μg Log in to see 15至18个工作日
$656.00
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大肠杆菌(E. Coli) 小鼠 非结合性   100 μg Log in to see 11至18个工作日
$582.75
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大肠杆菌(E. Coli) 非结合性   10 μg Log in to see 11至16个工作日
$783.93
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GZMK 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,

Rat (Rattus)

Human , , ,
,

更多Granzyme K (Granzyme 3, Tryptase II) (GZMK)互动伙伴

Mouse (Murine) Granzyme K (Granzyme 3, Tryptase II) (GZMK) interaction partners

  1. these data suggest that granzyme K does not play an essential role in viral immunity or cytotoxicity

  2. Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC).

  3. The data suggest that T-killer cells control lymphocytic choriomeningitis virus through non-cytotoxic processes that involve gzmK.

  4. It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1, Il6st, Gzmk, and Hspb3 genes' coexpression network.

  5. GzmK-induced caspase-independent death occurs through Bid-dependent mitochondrial damage that is different from GzmA

  6. grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B.

Human Granzyme K (Granzyme 3, Tryptase II) (GZMK) interaction partners

  1. Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1.

  2. Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells.

  3. Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC).

  4. Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 signaling during the antimicrobial innate immune response.

  5. Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56(bright) natural killer (NK) cells toward activated T cells.

  6. Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3.

  7. The 2.2-A crystal structure reveals a rigid zymogen with unusual features

  8. The present findings thus introduce the possibility that human beta-tryptase, after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart.

  9. We found human GzmK triggers rapid cell death independently of caspase activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks.

  10. GzmK-induced caspase-independent death occurs through Bid-dependent mitochondrial damage that is different from GzmA

  11. Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis.

  12. GrK not only constitutes a redundant functional backup mechanism that assists GrA-induced cell death but that it also displays a unique function by cleaving its own specific substrates.

  13. p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy.

Rabbit Granzyme K (Granzyme 3, Tryptase II) (GZMK) interaction partners

  1. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.

蛋白简介Granzyme K (Granzyme 3, Tryptase II) (GZMK)

蛋白简介

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.

Gene names and symbols associated with GZMK

  • granzyme K (GZMK)
  • granzyme K (Gzmk)
  • TRYP2 蛋白

Protein level used designations for GZMK

NK-Tryp-2 , NK-tryptase-2 , RNK-Tryp-2 , fragmentin-3 , granzyme 3 , granzyme K , granzyme K (serine protease, granzyme 3; tryptase II) , granzyme-3 , tryptase II

GENE ID SPECIES
100052126 Equus caballus
14945 Mus musculus
29165 Rattus norvegicus
3003 Homo sapiens
100233185 Sus scrofa
426168 Gallus gallus
100727863 Cavia porcellus
100345938 Oryctolagus cuniculus
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