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GZMK product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. 再加上，我们可以发Granzyme K (Granzyme 3, Tryptase II) 抗体 (84) 和 Granzyme K (Granzyme 3, Tryptase II) 试剂盒 (31)和数多这个蛋白质的别的产品。
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these data suggest that granzyme K does not play an essential role in viral immunity or cytotoxicity
Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC).
The data suggest that T-killer cells control lymphocytic choriomeningitis virus through non-cytotoxic processes that involve gzmK.
It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1, Il6st, Gzmk, and Hspb3 genes' coexpression network.
GzmK-induced caspase-independent death occurs through Bid-dependent mitochondrial damage that is different from GzmA
grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B.
Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1.
Carbamate pesticides significantly reduced the intracellular levels of perforin, GrA, GrB, Gr3/K, and GRN in NK-92CI cells.
Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 signaling during the antimicrobial innate immune response.
Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56(bright) natural killer (NK) cells toward activated T cells.
Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3.
The 2.2-A crystal structure reveals a rigid zymogen with unusual features
The present findings thus introduce the possibility that human beta-tryptase, after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart.
We found human GzmK triggers rapid cell death independently of caspase activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks.
Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis.
GrK not only constitutes a redundant functional backup mechanism that assists GrA-induced cell death but that it also displays a unique function by cleaving its own specific substrates.
p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.
, granzyme 3
, granzyme K
, granzyme K (serine protease, granzyme 3; tryptase II)
, tryptase II