Glycine Dehydrogenase 蛋白 (GLDC)

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). 再加上,我们可以发Glycine Dehydrogenase 抗体 (71)Glycine Dehydrogenase 试剂盒 (27)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GLDC 104174 Q91W43
GLDC 2731 P23378
GLDC 309312  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至18个工作日
$858.00
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$325.44
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大肠杆菌(E. Coli) 小鼠 T7 tag,His tag 100 μg Log in to see 15至18个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性   100 μg Log in to see 11至18个工作日
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大肠杆菌(E. Coli) 大鼠 非结合性   100 μg Log in to see 11至18个工作日
$582.75
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GLDC 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,
,
Human , ,
,
Rat (Rattus)

更多Glycine Dehydrogenase (GLDC)互动伙伴

Mouse (Murine) Glycine Dehydrogenase (GLDC) interaction partners

  1. Exencephaly and ventriculomegaly were detectable by High-frequency ultrasound in homozygous Gldc-deficient mouse embryos indicating this to be an effective tool to study CNS development.

  2. These studies support a direct relationship between p53 mutations and GLDC expression in B cell lymphoma.

  3. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice through limiting supply of one-carbon units from mitochondrial folate metabolism.

  4. Results suggest that there is a direct correlation between ischemic injury and extracellular glycine concentration maintained by glycine decarboxylase and the glycine cleavage multienzyme system.

Human Glycine Dehydrogenase (GLDC) interaction partners

  1. A novel compound heterozygous variant was identified in the GLDC gene in a Chinese family with non-ketotic hyperglycinemia

  2. it was concluded that elevated serum GLDC may increase lung cancer risk, and that smoking, GLDC, the miR29 family and DNMT signaling pathways may serve an important role in early malignant transformation during the development of lung cancer.

  3. a comprehensive functional and structural analysis of 19 GLDC missense variants identified in a cohort of 26 nonketotic hyperglycinemia patients was performed

  4. The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT

  5. We show that the combination of GLDC and HIF-1alpha expression is an independent prognostic factor in early-stage lung non-small cell cancer

  6. Data indicate no mutation was found in glycine cleavage system protein-H (GCSH) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT) are the main cause of glycine encephalopathy in Malaysian population.

  7. study reports a novel mutation, c.2296G>T (p.Gly766Cys), in exon 19 of the glycine decarboxylase (GLDC) gene in a consanguineous Indian couple with a history of 4 neonatal deaths

  8. Identification of a splice acceptor site mutation and five different non-synonymous variants in GLDC were found in patients with neural tube defects.

  9. Study shows that glycine metabolism and the metabolic enzyme glycine decarboxylase (GLDC) drive tumor-initiating cells and tumorigenesis in non-small cell lung cancer.

  10. Heterozygous GLDC gene mutation in transient neonatal hyperglycinemia.

  11. Missense and nonsense mutations found in glycine encephalopathy

  12. Three adults with mild hyperglycinemia, infantile hypotonia, mental retardation, behavioral hyperirritability, and aggressive outbursts were screened for glycine decarboxylase mutations; two novel missense mutations were found.

  13. The mutation in this nonketotic hyperglycinemia kindred led to missplicing and reduced GLDC (glycine decarboxylase) expression.

  14. Single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is associated with glycine encephalopathy

  15. the nonketotic hyperglycinemia is due to a novel GLDC mutation.

  16. forty different gene alterations in the GLDC gene were identified in patients with glycine encephalopathy

  17. A screening system for GLDC deletions by multiplex ligation-dependent probe amplification identified 14 deletions of different length & Alu-mediated recombination in non-ketotic hyperglycinaemia patients.

  18. a histidine-to-aspartic acid change at amino acid position 371 (p. His371Asp mutation) in the glycine decarboxylase in a non-ketotic hyperglycemia patient.

蛋白简介Glycine Dehydrogenase (GLDC)

蛋白简介

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).

Gene names and symbols associated with Glycine Dehydrogenase 蛋白 (GLDC)

  • glycine dehydrogenase (decarboxylating) GcvP (gcvP)
  • glycine dehydrogenase (gcvP)
  • glycine dehydrogenase (Tb927.7.1910)
  • glycine cleavage system P-protein (gcvP)
  • glycine decarboxylase (Gldc)
  • glycine decarboxylase (GLDC)
  • glycine dehydrogenase (decarboxylating) (gldc)
  • glycine decarboxylase S homeolog (gldc.S)
  • D030049L12Rik 蛋白
  • D19Wsu57e 蛋白
  • DDBDRAFT_0219205 蛋白
  • DDBDRAFT_0231130 蛋白
  • DDB_0219205 蛋白
  • DDB_0231130 蛋白
  • fb23b05 蛋白
  • GCE 蛋白
  • GCSP 蛋白
  • gldc 蛋白
  • HYGN1 蛋白
  • PSPTO1276 蛋白
  • Tb07.43M14.350 蛋白
  • wu:fb23b05 蛋白
  • zgc:66198 蛋白

Protein level used designations for Glycine Dehydrogenase 蛋白 (GLDC)

glycine dehydrogenase , glycine cleavage system P protein , glycine dehydrogenase [decarboxylating], mitochondrial , glycine cleavage system protein P , glycine decarboxylase P-protein , glycine cleavage system protein P) , glycine decarboxylase , glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P) , glycine decarboxylase, glycine cleavage system protein P) , glycine dehydrogenase (decarboxylating), mitochondrial , glycine decarboxylase S homeolog , glycine dehydrogenase (decarboxylating) S homeolog

GENE ID SPECIES
1168636 Shewanella oneidensis MR-1
1182912 Pseudomonas syringae pv. tomato str. DC3000
3196586 Ruegeria pomeroyi DSS-3
3658401 Trypanosoma brucei brucei strain 927/4 GUTat10.1
8626028 Dictyostelium discoideum AX4
104174 Mus musculus
2731 Homo sapiens
374222 Gallus gallus
309312 Rattus norvegicus
481534 Canis lupus familiaris
321621 Danio rerio
379833 Xenopus laevis
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