anti-Glial Cells Missing Homolog 2 (Drosophila) (GCM2) 抗体

GCM2 is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. 再加上,我们可以发GCM2 蛋白 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
GCM2 9247 O75603
GCM2 107889 O09102
GCM2 291047  
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Cow 非结合性 WB Host: Rabbit Target Name: GCM2 Sample Tissue: Human Hela Whole Cell Antibody Dilution: 1ug/ml 100 μL Log in to see 2至3个工作日
$289.00
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非结合性 WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1至2个工作日
$358.60
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非结合性 ELISA, WB   100 μL Log in to see 16 Days
$181.73
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非结合性 WB   100 μL Log in to see 7至9个工作日
$507.83
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非结合性 WB   100 μL Log in to see 2至3个工作日
$289.00
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HRP IHC (p), WB   100 μL Log in to see 14至21个工作日
$405.90
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FITC IF (p)   100 μL Log in to see 14至21个工作日
$405.90
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Cy5.5 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
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Cy3 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
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Alexa Fluor 555 IF (p)   100 μL Log in to see 14至21个工作日
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更多抗GCM2的相互作用对抗体

Zebrafish Glial Cells Missing Homolog 2 (Drosophila) (GCM2) interaction partners

  1. Overexpression of gcm2 mRNA resulted in a significant increase in the numbers of ecac (显示 TRPV6 抗体)-expressing ionocytes and Ca2 (显示 CA2 抗体)+ uptake.

  2. PTH1 (显示 PTH 抗体) morphants failed to express gcm2. Coinjection of PTH1 (显示 PTH 抗体) morpholino with gcm2 capped RNA rescued the phenotypes observed in the PTH1 (显示 PTH 抗体) morphants, suggesting that the defects in PTH1 (显示 PTH 抗体)-deficient fish were caused, at least in part, by the suppression of gcm2.

  3. Results suggest that an acquisition of enhancers for the expression of gcm2 contributes to a diversity of ionocytes in zebrafish during evolution.

  4. role of Shh (显示 SHH 抗体) signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium

  5. Results suggest a role for glial cells missing 2 during the evolution of divergent pharyngeal morphologies.

  6. Gcm-2 is required for the formation of the internal gill buds in zebrafish

  7. The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase (显示 ATP6AP1 抗体)-rich cells in zebrafish.

Human Glial Cells Missing Homolog 2 (Drosophila) (GCM2) interaction partners

  1. The present study investigated the prevalence of the Y282D variant of the GCM2 gene and its association with clinical parameters in patients with a definitive histological diagnosis of sporadic parathyroid carcinoma (SPC) or atypical adenoma (AA).

  2. GCM2-associated primary hyperparathyroidism patients have greater preoperative parathyroid hormone (显示 PTH 抗体) levels, a greater rate of multigland disease, a lesser rate of biochemical cure

  3. Our results demonstrate that germline-activating mutations affecting the C-terminal conserved inhibitory domain of GCM2 can cause familial isolated hyperparathyroidism.

  4. Gata3 (显示 GATA3 抗体) interacted with Gcm2 and MafB (显示 MAFB 抗体), two known transcriptional regulators of parathyroid development, and synergistically stimulated the PTH (显示 PTH 抗体) promoter.

  5. The higher frequency of GCM2 282D in primary hyperparathyroidismand enhanced transcriptional activity of this variant supports the notion that it could contribute causally to parathyroid tumorigenesis

  6. we identified the genetic defect in 35% of hypoparathyroidism patients in our cohort and discovered novel GCM2 mutations including submicroscopic deletion that was undetectable by array comparative genomic hybridization

  7. Four single nucleotide polymorphisms of GCMB gene were found in the GCMB gene (c.-44T > C [rs16870746], c.91-242A > G [rs9379881], c.343+163G > A [rs9393726], and c.583-72A > T [rs2076257]) in our cohort.

  8. First described GCM2 mutation in exon 3 in patients with severe congenital hypoparathyroidism.

  9. Data suggest that replacement of cysteine 106 with arginine (C106R) would interfere with DNA binding of glial cells missing B (GCMB).

  10. We conclude that mutations in the transcription factor GCMB do not seem to play a major role in the pathogenesis of primary hyperparathyroidism.

Mouse (Murine) Glial Cells Missing Homolog 2 (Drosophila) (GCM2) interaction partners

  1. results suggest that MafB (显示 MAFB 抗体) regulates later steps of parathyroid development, that is, separation from the thymus and migration toward the thyroid. MafB (显示 MAFB 抗体) also regulates the expression of PTH (显示 PTH 抗体) in cooperation with Gcm2

  2. Gcm2 (glial cells missing 2) are involved in the epigenetic regulation of Hes5 (显示 HES5 抗体) transcription by DNA demethylation independently of DNA replication.

  3. role of Shh (显示 SHH 抗体) signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium

  4. GCM (显示 GCM1 抗体) domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain.

  5. Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia.

GCM2 抗原简介

蛋白简介

This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.

Gene names and symbols associated with GCM2

  • glial cells missing homolog 2 (GCM2) 抗体
  • glial cells missing homolog 2 (Drosophila) (gcm2) 抗体
  • glial cells missing homolog 2 S homeolog (gcm2.S) 抗体
  • glial cells missing homolog 2 (Drosophila) (Gcm2) 抗体
  • glial cells missing homolog 2 (Gcm2) 抗体
  • gcm-2 抗体
  • Gcm-rs1 抗体
  • Gcm1 抗体
  • Gcm1-rs2 抗体
  • GCMB 抗体
  • hGCMb 抗体

Protein level used designations for GCM2

chorion-specific transcription factor GCMb , glial cells missing 2 , gcmB transcription factor , glial cell missing-like protein , transcription factor glial cells missing-2 , transcription factor Glial cells missing-2 , glial cells missing protein homolog 2 , glial cells missing homolog 2 , GCM motif protein 2 , glial cells missing homolog b , glide/gcm protein homolog , mGCMb

GENE ID SPECIES
428478 Gallus gallus
449615 Danio rerio
496398 Xenopus laevis
539454 Bos taurus
100228942 Taeniopygia guttata
100358264 Oryctolagus cuniculus
9247 Homo sapiens
107889 Mus musculus
488217 Canis lupus familiaris
291047 Rattus norvegicus
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