anti-Germ Cell Associated 2 (Haspin) (GSG2) 抗体

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. 再加上,我们可以发Germ Cell Associated 2 (Haspin) 蛋白 (7)Germ Cell Associated 2 (Haspin) 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
GSG2 83903 Q8TF76
GSG2 687827  
GSG2 14841 Q9Z0R0
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antibodies-online.cn销售最多的anti-Germ Cell Associated 2 (Haspin) 抗体

Showing 10 out of 53 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB WB Suggested Anti-GSG2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: 721_B cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 WB WB Suggested Anti-GSG2 Antibody Titration: 1.0 ug/ml Positive Control: Placenta 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
详细
非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
详细
非结合性 ELISA, WB Western blot analysis GSG2 using Jurkat whole cell lysates 100 μL Log in to see 11至12个工作日
$390.77
详细
非结合性 IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: GSG2 Antibody [NBP1-26626] - Human prostate carcinoma. Antibody used at a dilution of 1:200. 0.1 mL Log in to see 7至9个工作日
$559.35
详细
非结合性 IHC (p), WB Western Blot at 1:1000 dilution Lane 1: human testis lysate Lane 2: Daudi whole cell lysate Lysates/proteins at 20 ug per lane. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL Log in to see 2至3个工作日
$515.63
详细
非结合性 IHC (p), WB Haspin Antibody (R330) (ABIN1882168) western blot analysis in Daudi,Raji cell line lysates (35 µg/lane). This demonstrates the Haspin antibody detected the Haspin protein (arrow). Haspin Antibody (R330) (ABIN1882168) western blot analysis in Daudi,Raji cell line lysates (35 µg/lane). This demonstrates the Haspin antibody detected the Haspin protein (arrow). 400 μL Log in to see 10至11个工作日
$385.00
详细
非结合性 WB Western Blot: GSG2 Antibody [NBP1-79837] - Human placenta Lysate 1ug/ml Gel Concentration 12% 100 μL Log in to see 8至11个工作日
$488.73
详细
小鼠 非结合性 WB Western Blot analysis of GSG2 expression in transfected 293T cell line by GSG2 MaxPab polyclonal antibody.Lane 1: GSG2 transfected lysate(88.50 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 11至12个工作日
$440.00
详细

引用最多的anti-Germ Cell Associated 2 (Haspin) 抗体

  1. Human Polyclonal GSG2 Primary Antibody for IHC (p), WB - ABIN1882168 : Dai, Sultan, Taylor, Higgins: The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. in Genes & development 2005 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal GSG2 Primary Antibody for WB - ABIN949715 : Wang, Wei, Du, Cao, Zhang, Liu, Liu, Chen, Ma: H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis. in Cell cycle (Georgetown, Tex.) 2016 (PubMed)

更多抗Germ Cell Associated 2 (Haspin)的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

  1. These data provide insight into how Hasp and Hig construct the synaptic cleft matrix and regulate the differentiation of cholinergic synapses, and also illuminate a previously unidentified architecture within synaptic clefts

Human Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

  1. The results indicate a kinase-dependent role for Haspin in antagonizing Wapl and protecting centromeric cohesion in mitosis.

  2. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B.

  3. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved.

  4. Autosomal recessive RP associated with mutations in the male germ cell-associated kinase (MAK) gene is associated with preservation of foveal vision even in advanced stages of retinal degeneration despite similar rates of peripheral visual field loss to other forms of autosomal recessive RP

  5. This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors

  6. Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool.

  7. Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing.

  8. Haspin inhibitors reveal centromeric roles of Aurora B in chromosome movement and spindle checkpoint signaling

  9. Aurora B phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B and Haspin functions in mitosis

  10. findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells

  11. phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B during mitosis

  12. Haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion.

  13. Haspin is a relatively newly discovered kinase that phosphorylates histone H3 during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW]

  14. This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis

  15. Haspin is required to maintain centromeric cohesion during mitosis.

Mouse (Murine) Germ Cell Associated 2 (Haspin) (GSG2) interaction partners

  1. These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes.

  2. Data implicate haspin as a regulator of the chromosomal passenger complex and chromosome segregation during meiosis I.

  3. the tissue-dependent and differentially methylated region functions as a modulator in a DNA methylation-dependent manner; Gsg2 is under epigenetic control

  4. the 193-bp DNA sequence in Haspin promotor is sufficient for the specific, bidirectional, and synchronous expression in germ cells in the testis.

Germ Cell Associated 2 (Haspin) (GSG2) 抗原简介

蛋白简介

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity).

Gene names and symbols associated with GSG2

  • putative serine/threonine-protein kinase haspin homolog (LOC552287) 抗体
  • histone H3 associated protein kinase (HASPIN) 抗体
  • CG40080 gene product from transcript CG40080-RA (Haspin) 抗体
  • uncharacterized LOC100122327 (LOC100122327) 抗体
  • histone H3 associated protein kinase (Haspin) 抗体
  • BcDNA:LD07633 抗体
  • CG40080 抗体
  • Dmel\\CG40080 抗体
  • Haspin 抗体
  • NV16901 抗体

Protein level used designations for GSG2

serine/threonine-protein kinase haspin-like protein , germ cell associated 2 (haspin) , haspin , CG40080-PA , Haspin-PA , putative serine/threonine-protein kinase haspin homolog , H-haspin , germ cell-specific gene 2 protein , haploid germ cell-specific nuclear protein kinase , serine/threonine-protein kinase haspin

GENE ID SPECIES
552287 Apis mellifera
748101 Pan troglodytes
3355064 Drosophila melanogaster
100122327 Nasonia vitripennis
83903 Homo sapiens
767819 Bos taurus
687827 Rattus norvegicus
14841 Mus musculus
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