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Gasdermin D is a member of the gasdermin family. 再加上，我们可以发Gasdermin D 抗体 (32) 和 Gasdermin D 蛋白 (6)和数多这个蛋白质的别的产品。
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High GSDMD expression is associated with tumor-node-metastasis in nonsmall cell lung cancer.
the gasdermin-D pore: Executor of pyroptotic cell death
Results implicate pyroptosis induced by the CASP11 (显示 SCAF11 ELISA试剂盒)/4-GSDMD pathway in the pathogenesis of alcoholic hepatitis
The present study not only contributes to our understanding of GSDMD recognition by inflammatory caspases but also reports a specific inhibitor for these caspases that can serve as a tool for investigating inflammasome signaling.
Pyroptosis regulator gasdermin D was necessary for IL-1beta (显示 IL1B ELISA试剂盒) secretion from living macrophages that have been exposed to inflammasome activators, such as bacteria and their products or host-derived oxidized lipids
These findings reveal that GSDMD-C acts as an auto-inhibition executor and GSDMD-N could form pore structures via a charge-charge interaction upon cleavage by caspases during cell pyroptosis.
This study reveals the pore-forming activity of GSDMD and channel-forming activity of MLKL determine different ways of plasma membrane rupture in pyroptosis and necroptosis.
GsdmD p30 kills cells by forming pores that compromise the integrity of the cell membrane.
Data, including data from studies using recombinant fusion forms of GSDMD, suggest that GSDMD participates in inflammasome-dependent pyroptosis of macrophages in response to various stimuli; this mechanism involves proteolysis of GSDMD by caspase-1 (显示 CASP1 ELISA试剂盒) and caspase-11 (显示 CASP4 ELISA试剂盒).
Remarkably, the Enterovirus 71 protease 3C directly targets GSDMD and induces its cleavage, which is dependent on the protease activity.
Because DFNA5-induced secondary necrosis and GSDMD-induced pyroptosis are dependent on CASP3 (显示 CASP3 ELISA试剂盒) activation, we propose that they are forms of programmed necrosis.
Results implicate pyroptosis induced by the CASP11 (显示 CASP4 ELISA试剂盒)/4-GSDMD pathway in the pathogenesis of alcoholic hepatitis
Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta (显示 IL1B ELISA试剂盒) in both canonical and non-canonical inflammasome responses.
identification of gasdermin D (Gsdmd) by genome-wide clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 nuclease screens of caspase-11 (显示 CASP4 ELISA试剂盒)- and caspase-1 (显示 CASP1 ELISA试剂盒)-mediated pyroptosis in mouse bone marrow macrophages
gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation
This study clearly shows that Gsdmd is not essential for development of mouse intestinal tract or epithelial cell differentiation.
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
gasdermin domain containing 1
, gasdermin D
, gasdermin domain-containing protein 1