anti-Gasdermin D (GSDMD) 抗体

Gasdermin D is a member of the gasdermin family. 再加上,我们可以发Gasdermin D 试剂盒 (13)Gasdermin D 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
GSDMD 79792 P57764
GSDMD 69146 Q9D8T2
GSDMD 315084  
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antibodies-online.cn销售最多的anti-Gasdermin D 抗体

Showing 10 out of 32 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: GSDMDC1 Antibody [NBP2-33422] - Ovarian cancer Immunohistochemistry-Paraffin: GSDMDC1 Antibody [NBP2-33422] - Liver 0.1 mL Log in to see 10至13个工作日
$494.38
详细
小鼠 非结合性 ELISA, IF, IHC, WB Immunofluorescence of monoclonal antibody to GSDMDC1 on HeLa cell (antibody concentration 10 µg/mL). GSDMDC1 monoclonal antibody (M01), clone 3F12-1B2 Western Blot analysis of GSDMDC1 expression in Jurkat. 100 μg Log in to see 8至11个工作日
$527.50
详细
非结合性 IHC, WB Western blot analysis of extracts of Jurkat cells, using GSDMD antibody. ABIN6273119 at 1/100 staining Human lymph node tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11至12个工作日
$390.77
详细
小鼠 非结合性 EIA, IF, IHC (p), WB 50 μg Log in to see 6至8个工作日
$550.00
详细
非结合性 WB Western blot analysis of extracts of mouse lung and rat liver cell lines, using GSDMD antibody. Western blot analysis of extracts of various cell lines, using GSDMD antibody (ABIN4903834) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s. 100 μL Log in to see 16 Days
$366.77
详细
小鼠 非结合性 IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to GSDMDC1 on formalin-fixed paraffin-embedded human tonsil tissue. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to GSDMDC1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11至12个工作日
$440.00
详细
小鼠 非结合性 ELISA, IF, IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-GSDMD / DFNA5L antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11至14个工作日
$550.00
详细
小鼠 非结合性 ELISA, IF, IHC (p), WB Immunohistochemistry-Paraffin: GSDMDC1 Antibody (3F12-1B2) [NBP1-69898] - Analysis of anti-GSDMD / DFNA5L antibody with human small intestine at concentration 5 ug/ml. 0.05 mg Log in to see 34 Days
$587.60
详细
非结合性 WB Western Blot: GSDMDC1 Antibody [NBP2-14973] - Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE, antibody diluted at 1:500. 0.1 mL Log in to see 8至11个工作日
$516.98
详细
非结合性 WB Western Blot analysis of GSDMD expression in transfected 293T cell line by GSDMD MaxPab polyclonal antibody.Lane 1: GSDMDC1 transfected lysate(52.80 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 11至12个工作日
$425.71
详细

引用最多的anti-Gasdermin D 抗体

  1. Human Polyclonal GSDMD Primary Antibody for ICC, IF - ABIN4316340 : Liu, Zhang, Ruan, Pan, Magupalli, Wu, Lieberman: Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. in Nature 2016 (PubMed)
    Show all 4 Pubmed References

更多抗Gasdermin D的相互作用对抗体

Human Gasdermin D (GSDMD) interaction partners

  1. lncRNA RP185F18.6 and DeltaNp63 may be considered unfavorable biomarkers, whereas GSDMD may be a favorable biomarker in colorectal cancer (CRC) ; these markers may prove valuable in the future diagnosis and prognosis of CRC

  2. High GSDMD expression is associated with tumor-node-metastasis in nonsmall cell lung cancer.

  3. the gasdermin-D pore: Executor of pyroptotic cell death

  4. Results implicate pyroptosis induced by the CASP11/4-GSDMD pathway in the pathogenesis of alcoholic hepatitis

  5. The present study not only contributes to our understanding of GSDMD recognition by inflammatory caspases but also reports a specific inhibitor for these caspases that can serve as a tool for investigating inflammasome signaling.

  6. Pyroptosis regulator gasdermin D was necessary for IL-1beta secretion from living macrophages that have been exposed to inflammasome activators, such as bacteria and their products or host-derived oxidized lipids

  7. These findings reveal that GSDMD-C acts as an auto-inhibition executor and GSDMD-N could form pore structures via a charge-charge interaction upon cleavage by caspases during cell pyroptosis.

  8. This study reveals the pore-forming activity of GSDMD and channel-forming activity of MLKL determine different ways of plasma membrane rupture in pyroptosis and necroptosis.

  9. GsdmD p30 kills cells by forming pores that compromise the integrity of the cell membrane.

  10. Data, including data from studies using recombinant fusion forms of GSDMD, suggest that GSDMD participates in inflammasome-dependent pyroptosis of macrophages in response to various stimuli; this mechanism involves proteolysis of GSDMD by caspase-1 and caspase-11.

  11. Remarkably, the Enterovirus 71 protease 3C directly targets GSDMD and induces its cleavage, which is dependent on the protease activity.

  12. The pyroptosis is redefined as gasdermin D-mediated programmed necrosis. Gasdermin D are associated with various genetic diseases, and their cellular function and mechanism of activation.

  13. Overall, these data demonstrate that GSDMD is the direct and final executor of pyroptotic cell death.

  14. Studies show that the membrane-pores composed of gasdermin D-N domains (GSDMD-N domain) are required for pyroptosis.

  15. Studies indicate that gasdermin D (GSDMD) is cleaved by the activated caspases-1/4/5/11 between its N-terminal and C-terminal domains.

  16. Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta in both canonical and non-canonical inflammasome responses.

  17. GSDMD N-terminal cleavage product oligomerizes in membranes to form pores that are visible by electron microscopy

  18. caspase-1 and caspase-4/5/11 specifically cleaved the linker between the amino-terminal gasdermin-N and carboxy-terminal gasdermin-C domains in GSDMD, which was required and sufficient for pyroptosis

  19. Study investigated the expression pattern of the GSDM family genes in the upper gastrointestinal epithelium and cancers.

Mouse (Murine) Gasdermin D (GSDMD) interaction partners

  1. Because DFNA5-induced secondary necrosis and GSDMD-induced pyroptosis are dependent on CASP3 activation, we propose that they are forms of programmed necrosis.

  2. the gasdermin-D pore: Executor of pyroptotic cell death

  3. Results implicate pyroptosis induced by the CASP11/4-GSDMD pathway in the pathogenesis of alcoholic hepatitis

  4. The present study not only contributes to our understanding of GSDMD recognition by inflammatory caspases but also reports a specific inhibitor for these caspases that can serve as a tool for investigating inflammasome signaling.

  5. This study reveals the pore-forming activity of GSDMD and channel-forming activity of MLKL determine different ways of plasma membrane rupture in pyroptosis and necroptosis.

  6. Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta in both canonical and non-canonical inflammasome responses.

  7. identification of gasdermin D (Gsdmd) by genome-wide clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 nuclease screens of caspase-11- and caspase-1-mediated pyroptosis in mouse bone marrow macrophages

  8. gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1beta maturation

  9. This study clearly shows that Gsdmd is not essential for development of mouse intestinal tract or epithelial cell differentiation.

Gasdermin D (GSDMD) 抗原简介

蛋白简介

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with anti-Gasdermin D (GSDMD) 抗体

  • gasdermin D (GSDMD) 抗体
  • gasdermin D (Gsdmd) 抗体
  • 1810036L03Rik 抗体
  • AW558049 抗体
  • DF5L 抗体
  • Dfna5l 抗体
  • GSDMD 抗体
  • Gsdmdc1 抗体
  • M2-4 抗体

Protein level used designations for anti-Gasdermin D (GSDMD) 抗体

gasdermin domain containing 1 , gasdermin-D , gasdermin D , gasdermin domain-containing protein 1

GENE ID SPECIES
513939 Bos taurus
609395 Canis lupus familiaris
697137 Macaca mulatta
739712 Pan troglodytes
100604427 Nomascus leucogenys
79792 Homo sapiens
69146 Mus musculus
315084 Rattus norvegicus
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