GLE1 RNA Export Mediator Homolog (Yeast) 蛋白 (GLE1)

GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. 再加上,我们可以发GLE1 RNA Export Mediator Homolog (Yeast) 抗体 (51)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GLE1 2733 Q53GS7
GLE1 362098 Q4KLN4
GLE1 74412 Q8R322
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GLE1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

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Human GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) interaction partners

  1. Data indicate 2 siblings with a homozygous p.I684T mutation in RNA export mediator (GLE1).

  2. These results imply that DBP5, GLE1 and IP6 (显示 GPRIN2 蛋白) have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK (显示 IPPK 蛋白) in intracellular mRNA metabolism.

  3. We identified bi-allelic mutations in GLE1 in two unrelated individuals with motor delays, feeding difficulties, and respiratory insufficiency who survived beyond the perinatal period. Each affected child had missense variants predicted to result in amino acid substitutions near the C-terminus of GLE1 that are predicted to disrupt protein-protein interaction or GLE1 protein targeting.

  4. It was concluded that the amyotrophic lateral sclerosis-linked Gle1-c.1965-2A>C mutation generates a protein isoform capable of both Gle1A- and Gle1B-ascribed functions, and thereby uncoupled from normal mechanisms of Gle1 regulation.

  5. We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein

  6. Restoration of miR (显示 MLXIP 蛋白)-127-3p and miR (显示 MLXIP 蛋白)-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1 (显示 UBXN11 蛋白), GLE1 and PDIA6 (显示 PDIA6 蛋白).

  7. We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis.

  8. Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review]

  9. Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1.

  10. Dbp5, Gle1-IP6 (显示 GPRIN2 蛋白) and Nup159: a working model for mRNP export.

蛋白简介GLE1 RNA Export Mediator Homolog (Yeast) (GLE1)

蛋白简介

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GLE1

  • CG14749 gene product from transcript CG14749-RA (CG14749)
  • nucleoporin GLE1 (CpipJ_CPIJ014147)
  • RNA export factor Gle1 (SJAG_03847)
  • GLE1, RNA export mediator (GLE1)
  • GLE1 RNA export mediator (Gle1)
  • GLE1 RNA export mediator (yeast) (Gle1)
  • 4933405K21Rik 蛋白
  • AA553313 蛋白
  • Dmel\\CG14749 蛋白
  • GLE1 蛋白
  • Gle1l 蛋白
  • hGLE1 蛋白
  • LCCS 蛋白
  • LCCS1 蛋白

Protein level used designations for GLE1

CG14749-PA , nucleoporin GLE1 , GLE1 RNA export mediator homolog , GLE1-like protein , GLE1-like, RNA export mediator , GLE1 RNA export mediator-like (yeast

GENE ID SPECIES
35849 Drosophila melanogaster
6047573 Culex quinquefasciatus
7050485 Schizosaccharomyces japonicus yFS275
417212 Gallus gallus
2733 Homo sapiens
362098 Rattus norvegicus
74412 Mus musculus
480704 Canis lupus familiaris
540982 Bos taurus
100172586 Pongo abelii
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