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Endothelial receptor that acts as an essential regulator of CNS angiogenesis. 再加上，我们可以发GPR124 抗体 (77) 和 GPR124 蛋白 (7)和数多这个蛋白质的别的产品。
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Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 (显示 DOCK1 ELISA试剂盒) and intersectin 1 (显示 ITSN1 ELISA试剂盒)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 (显示 DOCK1 ELISA试剂盒) = dedicator of cytokinesis protein 1 (显示 DOCK1 ELISA试剂盒) 180 kDa)
Observed an inverse correlation between the expression of miR-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR-138-5p on the sensitivity to gefitinib.
Thrombin (显示 F2 ELISA试剂盒)-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein (显示 CD28 ELISA试剂盒) disulfide-isomerase (显示 P4HB ELISA试剂盒).
TEM5 expression during capillary morphogenesis is induced by the small GTPase (显示 RACGAP1 ELISA试剂盒) Rac (显示 AKT1 ELISA试剂盒) and mediates contact inhibition of proliferation in endothelial cells.
Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v (显示 ITGAV ELISA试剂盒))beta3 to glycosaminoglycans
experiments indicate that Reck (显示 RECK ELISA试剂盒) and Gpr124 are part of the cell surface protein (显示 CD28 ELISA试剂盒) complex that transduces Wnt7a (显示 WNT7A ELISA试剂盒)- and Wnt7b (显示 WNT7B ELISA试剂盒)-specific signals in mammalian CNS Epithelial Cells to promote angiogenesis and regulate the BBB (显示 ALMS1 ELISA试剂盒).
Gpr124 is an endothelial GPCR (显示 GPBAR1 ELISA试剂盒) specifically required for endothelial Wnt (显示 WNT2 ELISA试剂盒) signaling and BBB (显示 ALMS1 ELISA试剂盒) integrity under pathological conditions in adult mice.
Vital role for GPR124 is potentiation of WNT7 (显示 WNT7B ELISA试剂盒)-induced canonical beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling with important implications for understanding and manipulating CNS-specific angiogenesis.
Gpr124 functions as coactivator of Wnt7a (显示 WNT7A ELISA试剂盒)- and Wnt7b (显示 WNT7B ELISA试剂盒)-stimulated canonical Wnt (显示 WNT2 ELISA试剂盒) signaling via Frizzled receptor and Lrp (显示 LRP1 ELISA试剂盒) coreceptor and that Gpr124-stimulated signaling functions in concert with Norrin (显示 NDP ELISA试剂盒)/Frizzled4 (显示 FZD4 ELISA试剂盒) signaling to control CNS vascular development
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
TGF-beta (显示 TGFB1 ELISA试剂盒) stimulates Gpr124 expression which is required for angiogenic sprouting into neural tissues.
study shows that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube; results demonstrate CNS-specific angiogenesis regulation by an endothelial receptor
The GPI (显示 ITGA2 ELISA试剂盒)-anchored MMP inhibitor Reck (显示 RECK ELISA试剂盒) and the adhesion GPCR (显示 GPRC6A ELISA试剂盒) Gpr124 are integral components of the Wnt7a (显示 WNT7A ELISA试剂盒)/Wnt7b (显示 WNT7B ELISA试剂盒)-specific signaling complex required for brain angiogenesis and dorsal root ganglia neurogenesis.
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube.
G-protein coupled receptor 124
, tumor endothelial marker 5
, G protein-coupled receptor 124
, probable G-protein coupled receptor 124-like