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Endothelial receptor that acts as an essential regulator of CNS angiogenesis. 再加上，我们可以发GPR124 蛋白 (7) 和 GPR124 试剂盒 (1)和数多这个蛋白质的别的产品。
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Human Polyclonal GPR124 Primary Antibody for IHC, ELISA - ABIN1003261
Carson-Walter, Watkins, Nanda, Vogelstein, Kinzler, St Croix: Cell surface tumor endothelial markers are conserved in mice and humans. in Cancer research 2001
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Human Polyclonal GPR124 Primary Antibody for IHC, ELISA - ABIN1003260
Vallon, Essler: Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. in The Journal of biological chemistry 2006
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Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1 (显示 ELMO1 抗体)-Dock180 (显示 DOCK1 抗体) and intersectin 1 (显示 ITSN1 抗体)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 (显示 ELMO1 抗体) = ELMO domain-containing protein 1 (显示 ELMOD1 抗体); Dock180 (显示 DOCK1 抗体) = dedicator of cytokinesis protein 1 (显示 DOCK1 抗体) 180 kDa)
Observed an inverse correlation between the expression of miR (显示 MLXIP 抗体)-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR (显示 MLXIP 抗体)-138-5p on the sensitivity to gefitinib.
Thrombin (显示 F2 抗体)-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein (显示 CD28 抗体) disulfide-isomerase (显示 P4HB 抗体).
TEM5 expression during capillary morphogenesis is induced by the small GTPase (显示 RACGAP1 抗体) Rac (显示 AKT1 抗体) and mediates contact inhibition of proliferation in endothelial cells.
Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v (显示 ITGAV 抗体))beta3 to glycosaminoglycans
experiments indicate that Reck (显示 RECK 抗体) and Gpr124 are part of the cell surface protein (显示 CD28 抗体) complex that transduces Wnt7a (显示 WNT7A 抗体)- and Wnt7b (显示 WNT7B 抗体)-specific signals in mammalian CNS Epithelial Cells to promote angiogenesis and regulate the BBB (显示 ALMS1 抗体).
Gpr124 is an endothelial GPCR (显示 GPBAR1 抗体) specifically required for endothelial Wnt (显示 WNT2 抗体) signaling and BBB (显示 ALMS1 抗体) integrity under pathological conditions in adult mice.
Vital role for GPR124 is potentiation of WNT7 (显示 WNT7B 抗体)-induced canonical beta-catenin (显示 CTNNB1 抗体) signaling with important implications for understanding and manipulating CNS-specific angiogenesis.
Gpr124 functions as coactivator of Wnt7a (显示 WNT7A 抗体)- and Wnt7b (显示 WNT7B 抗体)-stimulated canonical Wnt (显示 WNT2 抗体) signaling via Frizzled receptor and Lrp (显示 LRP1 抗体) coreceptor and that Gpr124-stimulated signaling functions in concert with Norrin (显示 NDP 抗体)/Frizzled4 (显示 FZD4 抗体) signaling to control CNS vascular development
GPR124, an orphan G protein-coupled receptor (显示 GPRC5C 抗体), is required for CNS-specific vascularization and establishment of the blood-brain barrier.
TGF-beta (显示 TGFB1 抗体) stimulates Gpr124 expression which is required for angiogenic sprouting into neural tissues.
study shows that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube; results demonstrate CNS-specific angiogenesis regulation by an endothelial receptor
The GPI (显示 ITGA2 抗体)-anchored MMP inhibitor Reck (显示 RECK 抗体) and the adhesion GPCR Gpr124 are integral components of the Wnt7a (显示 WNT7A 抗体)/Wnt7b (显示 WNT7B 抗体)-specific signaling complex required for brain angiogenesis and dorsal root ganglia neurogenesis.
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube.
G-protein coupled receptor 124
, tumor endothelial marker 5
, G protein-coupled receptor 124
, probable G-protein coupled receptor 124-like