Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase) 蛋白 (FUT8)

FUT8 encodes an enzyme belonging to the family of fucosyltransferases. 再加上,我们可以发FUT8 抗体 (69)FUT8 试剂盒 (20)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FUT8 53618 Q9WTS2
FUT8 2530 Q9BYC5
大鼠 FUT8 FUT8 432392 Q6EV76
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
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Baculovirus infected Insect Cells His tag 50 μg Log in to see 14至16个工作日
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Baculovirus infected Insect Cells Hamster His tag 50 μg Log in to see 14至16个工作日
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
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大肠杆菌(E. Coli) 小鼠 T7 tag,His tag 100 μg Log in to see 15至18个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性   100 μg Log in to see 11至18个工作日
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FUT8 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,
, ,
Human , , ,
, , ,

更多Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase) (FUT8)互动伙伴

Mouse (Murine) Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase) (FUT8) interaction partners

  1. our study provides the first direct evidence for the involvement of Fut8 in liver regeneration.

  2. Loss of core fucosylation on AMPARs enhanced their heteromerization, which increase sensitivity for postsynaptic depolarization and persistently activate N-methyl-d-aspartate receptors as well as Ca(2+) influx and CaMKII and then impair LTP.

  3. findings define FUT8 as a novel factor for hemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation

  4. FUT8 is up-regulated during epithelial-mesenchymal transition (EMT), a critical process for malignant transformation of tumor, via the transactivation of beta-catenin/lymphoid enhancer-binding factor-1 (LEF-1).

  5. These data suggest that reduced Fut8 activity is associated with the progression of COPD and serum Fut8 activity is a non-invasive predictive biomarker candidate for progression and exacerbation of COPD.

  6. Sensitivity of heterozygous alpha1,6-fucosyltransferase knock-out mice to cigarette smoke-induced emphysema: implication of aberrant transforming growth factor-beta signaling and matrix

  7. Increased expression and activity of alpha-1,6-fucosyltransferase (FUT8) in the liver are strongly linked to the age-related changes in protein glycosylation.

  8. alpha1,6-fucosylation plays an important role in the brain, and that it might be related to schizophrenia-like behaviors

  9. epidermal growth factor induced phosphorylation levels of the EGF receptor (EGFR) were substantially blocked in Fut8-/- cells. Consistent with this, EGFR-mediated JNK or ERK activation was significantly suppressed in Fut8-/- cells.

  10. EGFR-trypsin-PAR-2 pathway is suppressed in Fut8-/- mice.

  11. Reduced alpha4 1 integrin/vascular cell adhesion molecule 1 interactions lead to impaired pre-B cell repopulation in alpha 1,6-fucosyltransferase deficient mice

  12. Vascular endothelial growth factor receptor-2 (VEGFR-2) expression was significantly suppressed in Fut8(-/-) mice, suggesting that Fut8 was required for VEGFR-2 expression.

Human Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase) (FUT8) interaction partners

  1. expression in relation to p53 is a prognostic biomarker for patients with stage II and III colorectal cancer

  2. loss of function mutations in FUT8 cause a congenital disorder of glycosylation (FUT8-CDG) characterized by defective core fucosylation.

  3. we also demonstrated that overexpression of FUT8 might be responsible for the decreased PSA expression in prostate cancer specimens. To our knowledge, this is the first study reporting the functional role of fucosylated enzyme in the development of castration-resistant prostate cancer.

  4. This study thus provides insights into the interplay among FUT8, N-acetylglucosaminyltransferase , and GnT-V in N-linked glycosylation during the assembly of glycoproteins.

  5. Our results reveal a positive feedback mechanism of FUT8-mediated receptor core fucosylation that promotes TGF-b signaling and EMT, thus stimulating breast cancer cell invasion and metastasis.

  6. FUT8 is regulated by microRNAs and has a role in hepatocellular carcinoma progression

  7. the possibility that the higher fucose levels on cell surface glycans of aggressive anaplastic thyroid cancer samples (ATCs), compared to those of less aggressive papillary thyroid cancer samples(PTC), may be at least in part responsible for the more aggressive and metastatic phenotype of ATCs compared to PTCs, as the expression levels of FUCA1 and FUT8 were inversely related in these two types of cancers.

  8. We observed a strong correlation between EVI1 and alpha1, 6-fucosyltransferase (FUT8) in the chronic phase of the disease and both of them were found to be up-regulated with the progression of the disease.

  9. This study demonstrated that the alteration of FTU8 expression in the superior temporal gyrus of elderly patients with schizophrenia.

  10. results suggest that an appropriate polypeptide context or other adequate structural elements in the acceptor substrate could facilitate the core fucosylation by FUT8

  11. FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination.

  12. The production of the homogeneous core-fucosylated Man5GlcNAc2 glycoform of EPO in the FUT8-overexpressed HEK293S GnT I(-/-) cell line represents the first example of production of fully core-fucosylated high-mannose glycoforms.

  13. Expression of FUT8 can stratify breast cancer tissue and may be considered a prognostic marker for breast cancer patients

  14. MiR-198 was shown to target the 3'UTR of FUT8 directly to downregulate FUT8 expression.

  15. High expression of FUT8 is associated with an unfavorable clinical outcome in patients with potentially curatively resected NSCLCs, suggesting that FUT8 can be a prognostic factor.

  16. Our results suggest that FUT8 may be associated with aggressive PCa and thus is potentially useful for its prognosis.

  17. miR-122 and miR-34a are able to target FUT8 3'UTR

  18. Results suggest that FUT4-, FUT6- or FUT8-mediated MDR in human HCC is associated with the activation of the PI3K/Akt pathway and the expression of MRP1.

  19. alpha 1,6-fucosyltransferase 8 expression might be a good indicator of poor prognosis in hepatocellular carcinoma. High alpha 1,6-fucosyltransferase 8 expression may play an important role in hepatitis B virus-related hepatocellular carcinoma progression

  20. findings define FUT8 as a novel factor for hemoglobin production and demonstrate that core fucosylation plays an important role in erythroid differentiation

蛋白简介FUT8

蛋白简介

This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FUT8

  • fucosyltransferase 8 (FUT8)
  • fucosyltransferase 8 (Fut8)

Protein level used designations for FUT8

GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase , GDP-fucose--glycoprotein fucosyltransferase , alpha (1,6) fucosyltransferase , alpha-(1,6)-fucosyltransferase , alpha-1,6-fucosyltransferase , alpha1-6FucT , glycoprotein 6-alpha-L-fucosyltransferase , N-acetyl-beta-D-glucosaminidealpha-1,6-fucosyltransferase , Glycoprotein 6-alpha-L-fucosyltransferase , alpha 1,6 fucosyltransferase

GENE ID SPECIES
100052546 Equus caballus
53618 Mus musculus
2530 Homo sapiens
396933 Sus scrofa
281177 Bos taurus
432392 Rattus norvegicus
448804 Canis lupus familiaris
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