Free Fatty Acid Receptor 2 (FFAR2) ELISA试剂盒

FFAR2 encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. 再加上,我们可以发FFAR2 抗体 (97)FFAR2 蛋白 (7)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
FFAR2 2867 O15552
FFAR2 292794 Q76EI6
FFAR2 233079 Q8VCK6
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Human Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. FFAR2 and FFAR3 interact to form a heteromer in primary monocytes and macrophages via proximity ligation assay, and during heterologous expression in HEK293 cells via bimolecular fluorescence complementation and fluorescence resonance energy transfer. FFAR2 and FFAR3 may interact to form a receptor heteromer with signaling that is distinct from the parent homomers.

  2. Data suggest that the free fatty acid receptor 2 (FFA2/GPR43 receptor) plays an integral role in survival during and after sepsis.

  3. we show functional similarities but also some important differences between GPR84 and FFA2R in human phagocytes, thus providing some mechanistic insights into GPR84 regulation in blood neutrophils and cells recruited to an aseptic inflammatory site in vivo.

  4. Compared with the control group, the densitometric quantification and mean density of GPR43 and ChAT proteins, and expression of GPR43 and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.

  5. a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 and GPR41

  6. Short-chain fatty acids lowered TNF-alpha-induced MCP-1 expression by reducing phosphorylation of p38 MAPK and JNK in a GPR41/GRP43-dependent manner in renal cortical epithelial cells.

  7. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11.

  8. the results of mutagenesis studies based on the crystal structure of hFFA1 bound to TAK-875 at 2.3 A resolution to identify important residues for orthosteric agonist 6e inducing FFA2 activation.

  9. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII of FFA2, there are clear differences in how these interactions occur.

  10. FFAR2 signaling occurs by divergent G protein pathways.

  11. GPR3 agonism potentiates insulin secretion in isolated islets.

  12. GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1, while A549 cells overexpressing XBP1 displayed elevated GPR43 levels.

  13. FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis.

  14. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin secretion by coupling to Gi-type G proteins.

  15. [review] In vivo and in vitro studies suggest that short-chain fatty acid receptors (SCFAs) stimulate gut hormone secretion; therefore, the SCFA-FFA signal is likely to be important for gut physiological functions.

  16. GPR43 modulates NF-kappaB activity via beta-arrestin 2.

  17. Data indicate that a single mutation in human FFA2 of C4.57G resulted in a human FFA2 receptor with ligand selectivity similar to the bovine receptor.

  18. Propionate-stimulated GPR41 strongly coupled to ERK1/2 activation, while the coupling of linoleic acid-activated GPR40 and acetate-activated GPR43 was weaker.

  19. Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3

  20. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Mouse (Murine) Free Fatty Acid Receptor 2 (FFAR2) interaction partners

  1. In conclusion, we report a previously unappreciated role of GPR43 in promoting host timely inflammation resolution of Gram-negative bacteria-induced lung injury. In addition, our study demonstrates that acetate-binding GPR43 can be critical for recovery from Klebsiella pneumoniae-induced lung injury by modulating neutrophils and macrophage activity.

  2. results suggest that FFAR2 is an epigenetic tumor suppressor that acts at multiple stages of colon carcinogenesis

  3. graft-versus-host disease protective effect of short-chain fatty acids requires GPR43-mediated ERK phosphorylation and activation of the NLRP3 inflammasome in non-hematopoietic target tissues of the host

  4. this study shows that GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

  5. this study shows that free fatty acid receptor 2 promotes beta-cell proliferation

  6. this paper show that microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

  7. dual oxidase-2 and IL-6 play important roles in GPR43-mediated skin inflammation.

  8. Loss of Ffar2 expression is associated with leukemia.

  9. the role of GPR43 in adipose tissue macrophages, was examined.

  10. loss of FFAR2 is associated with colon tumorigenesis.

  11. Gestational glucose tolerance in WT mice, but not Ffar2-/- mice improved while on antibiotics. Gestational glucose tolerance worsened in Ffar2-/- mice during a second pregnancy. Maternal Ffar2 expression had no effect on the growth rates and glucose and glucose tolerance in the offspring.

  12. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11.

  13. A Western diet could aggravate the inflammatory colitis process; the activation of the GPR43 receptor pathway could be used as a new strategy to treat Crohn's Disease patients.

  14. FFAR2 signaling occurs by divergent G protein pathways.

  15. Data (including data from studies in knockout mice) suggest Ffar2 expression in pancreatic beta-cells plays role in gestational glucose homeostasis; this mechanism involves gut microbiome (which contributes to plasma short-chain fatty acid levels).

  16. High fat diet fed GPR43 KO mice develop glucose intolerance due to a defect in insulin secretion, reduced beta-cell mass and expression of differentiation genes. GPR3 agonism potentiates insulin secretion.

  17. GPR-43-deficient mice show a greatly decreased inflammatory reaction to knee injection of monosodium urate crystals in a mouse model of gout.

  18. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin secretion by coupling to Gi-type G proteins.

  19. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis.

  20. Data from transgenic mice suggest that Ffar2/Gpr43 and Ffar3/Gpr41 both act as sensors for short-chain fatty acids in enteroendocrine cells; Ffar2/Gpr43 appears to play this role alone in enteric leukocytes and Ffar3/Gpr41 alone in enteric neurons.

FFAR2 抗原简介

Antigen Summary

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels.

Gene names and symbols associated with FFAR2

  • free fatty acid receptor 2 (FFAR2) 抗体
  • free fatty acid receptor 2 (Ffar2) 抗体
  • FFA2R 抗体
  • GPCR43 抗体
  • Gpr43 抗体

Protein level used designations for FFAR2

G protein-coupled receptor 43 , G-protein coupled receptor 43 , free fatty acid activated receptor 2 , leukocyte-specific STAT-induced GPCR

GENE ID SPECIES
2867 Homo sapiens
292794 Rattus norvegicus
233079 Mus musculus
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