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The protein encoded by FOXN1 is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging.
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Human Polyclonal FOXN1 Primary Antibody for IF (p), IHC (p) - ABIN1387592
Volpi, Yamazaki, Brauer, van Rooijen, Hayashida, Slavotinek, Sun Kuehn, Di Rocco, Rivolta, Bortolomai, Du, Felgentreff, Ott de Bruin, Hayashida, Freedman, Marcovecchio, Capuder, Rath, Luche, Hagedorn et al.: EXTL3
mutations cause skeletal dysplasia, immune deficiency, and developmental delay. ... in The Journal of experimental medicine 2017
Human Polyclonal FOXN1 Primary Antibody for IHC (p), IHC - ABIN250004
Schlake, Schorpp, Maul-Pavicic, Malashenko, Boehm: Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype. in Developmental dynamics : an official publication of the American Association of Anatomists 2000
the foxn1-mcm2 (显示 MCM2 抗体) axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish
zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment
an evolutionarily conserved role of BMP signaling in the maintenance of Foxn1 expression.
FOXN1 founder Italian mutation identified in an indian newborn with severe combined immunodeficiency (显示 PRKDC 抗体).
Whole-exome sequencing in a South American coh (显示 RARB 抗体)ort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism s (显示 ALDH1A3 抗体)pectrum disorders.
Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency (显示 PRKDC 抗体) in a female infant is reported.
These results show that miR (显示 MLXIP 抗体)-18b and miR (显示 MLXIP 抗体)-518b are upstream controllers of FOXN1-directed epithelial lineage development.
The retinoid-related orphan receptor (显示 NR1D2 抗体) RORalpha promotes keratinocyte differentiation via FOXN1.
This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation.
results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation
role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review]
study uncovered a positive regulatory loop between FGFR3 (显示 FGFR3 抗体) and FOXN1 that underlies a benign versus malignant skin tumor phenotype
Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency (显示 PRKDC 抗体) associated with alopecia
data identify the transcription factor Foxn1 (显示 FOXN2 抗体) as a potential key epidermal regulator modifying both epidermal and dermal healing processes after cutaneous wounding
MicroRNA-205 maintains T cell development following stress by regulating Foxn1 (显示 FOXN2 抗体) and its two regulated targets, stem cell factor (显示 KITLG 抗体) and ccl25 (显示 CCL25 抗体), following stress.
this study identified Bmp4 (显示 BMP4 抗体) as a significant factor for improved maintenance of Foxn1 (显示 FOXN2 抗体) expression, promotion of thymic epithelial progenitor populations self-renewal and immature epithelial cell differentiation and survival
results show that Foxn1 (显示 FOXN2 抗体), and alleles under its control, are expressed in the pre-meiotic male germline, revealing a new tool for germline targeting of genes, and raising important concerns for gender selection when using Foxn1 (显示 FOXN2 抗体) regulatory elements.
this study shows that critical events in thymic lympho-stromal cross-talk and T cell selection are regulated by Foxn1 (显示 FOXN2 抗体)
sphingolipids and fatty acids associated with a decrease in glycerolipids suggest that the lipidome in mice skin is regulated by the Foxn1 (显示 FOXN2 抗体) gene
Foxn1 (显示 FOXN2 抗体) transcription factor regulates wound healing of skin through promoting epithelial-mesenchymal transition.
early differentiation and maturation of cortical and medullary thymic epithelial cells coincides with precise sub-lineage-specific regulation of Foxn1 (显示 FOXN2 抗体) expression levels.
Chromatin immunoprecipitation assay using RarB (显示 RARB 抗体) as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 (显示 ALDH1A3 抗体) and Foxn1 (显示 FOXN2 抗体) in mice.
The maturation and distribution of thymic epithelial cells in the Foxn1 (显示 FOXN2 抗体)(-/-) thymic rudiment and the thymopoiesis of this newly developed rudiment, were examined.
The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
forkhead box protein N1
, forkhead box N1
, forkhead box N protein
, forkhead box protein N1-like
, transcription factor Forkhead box protein N1
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, winged helix nude
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, winged-helix transcription factor nude
, HNF-3/forkhead homolog 11
, hepatocyte nuclear factor 3 forkhead homolog 11