Folliculogenesis Specific Basic Helix-Loop-Helix 蛋白 (FIGLA)

FIGLA encodes a protein that functions in postnatal oocyte-specific gene expression. 再加上,我们可以发FIGLA 抗体 (25)FIGLA 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
FIGLA 26910 O55208
FIGLA 344018 Q6QHK4
大鼠 FIGLA FIGLA 500239  
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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FIGLA 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human , ,
, ,

更多Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA)互动伙伴

Mouse (Murine) Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA) interaction partners

  1. GFP positive cells showed the expression of germ cell markers Vasa (显示 DDX4 蛋白), meiotic specific gene Stra8, Scp3 (显示 SYCP3 蛋白), oocyte markers Gdf9 (显示 GDF9 蛋白), Zp3 (显示 ZP3 蛋白) and Figla, indicating that this method could be used for the purification and selection of female germ cells

  2. Data suggest that a dynamic DNA CpG methylation in Sohlh2 (显示 SOHLH2 蛋白) and Figlalpha promoters, but not in the intron and exon sequences, is linked to regulation of gene expression, even though CpG islands are also present in their introns or exons.

  3. physiological expression of Figla plays a critical dual role in activation of oocyte-associated genes and repression of sperm-associated genes during normal postnatal oogenesis

  4. FIGLA is a central regulator of oocyte-specific genes that play roles in folliculogenesis, fertilization and early development.

Human Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA) interaction partners

  1. Biallelic mutations in FIGLA may be the cause of premature ovarian insufficiency (POI) . This study will aid researchers and clinicians in genetic counseling of POI and provides new insights into understanding the mode of genetic inheritance of FIGLA mutations in POI pathology.

  2. study identified an association between FIGLA gene variants and the occurrence of premature ovarian failure(POF (显示 POF1B 蛋白)) in the Indian population; findings suggest that the c.427G->C and c.557C->T alleles lead to an increased risk of POF (显示 POF1B 蛋白) in Indian women

  3. These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary.

  4. the p.140 delN mutation disrupted FIGLA binding to the TCF3 (显示 TCF3 蛋白) helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA.

蛋白简介FIGLA

蛋白简介

This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6.

Gene names and symbols associated with FIGLA

  • folliculogenesis specific basic helix-loop-helix (Figla)
  • folliculogenesis specific bHLH transcription factor (FIGLA)
  • folliculogenesis specific bHLH transcription factor (Figla)
  • folliculogenesis specific bHLH transcription factor L homeolog (figla.L)
  • folliculogenesis specific bHLH transcription factor (figla)
  • bhlhc8 蛋白
  • fig1a 蛋白
  • FIGalpha 蛋白
  • figla 蛋白
  • pof6 蛋白
  • RGD1564754 蛋白
  • zgc:109752 蛋白

Protein level used designations for FIGLA

FIG alpha , FIGalpha , factor in the germline alpha , transcription factor FIGa , class C basic helix-loop-helix protein 8 , folliculogenesis-specific basic helix-loop-helix protein , folliculogenesis specific basic helix-loop-helix , folliculogenesis specific bHLH transcription factor L homeolog , Figa

GENE ID SPECIES
26910 Mus musculus
344018 Homo sapiens
500239 Rattus norvegicus
495929 Xenopus laevis
387259 Danio rerio
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