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FIGLA encodes a protein that functions in postnatal oocyte-specific gene expression. 再加上，我们可以发FIGLA 抗体 (25) 和 FIGLA 试剂盒 (4)和数多这个蛋白质的别的产品。
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GFP positive cells showed the expression of germ cell markers Vasa, meiotic specific gene Stra8, Scp3, oocyte markers Gdf9, Zp3 and Figla, indicating that this method could be used for the purification and selection of female germ cells
Data suggest that a dynamic DNA CpG methylation in Sohlh2 and Figlalpha promoters, but not in the intron and exon sequences, is linked to regulation of gene expression, even though CpG islands are also present in their introns or exons.
physiological expression of Figla plays a critical dual role in activation of oocyte-associated genes and repression of sperm-associated genes during normal postnatal oogenesis
FIGLA is a central regulator of oocyte-specific genes that play roles in folliculogenesis, fertilization and early development.
Biallelic mutations in FIGLA may be the cause of premature ovarian insufficiency (POI) . This study will aid researchers and clinicians in genetic counseling of POI and provides new insights into understanding the mode of genetic inheritance of FIGLA mutations in POI pathology.
study identified an association between FIGLA gene variants and the occurrence of premature ovarian failure(POF) in the Indian population; findings suggest that the c.427G->C and c.557C->T alleles lead to an increased risk of POF in Indian women
Expression of mRNA observed in ovarian follicles, mature oocytes, and less frequently in preimplantation embryos.
These results suggest that FIGLA is involved in continued oocyte survival as primordial follicles form in the human as in the rodent ovary.
the p.140 delN mutation disrupted FIGLA binding to the TCF3 helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA.
may have a role in the development of primordial follicle before zona pellucida formation
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6.
, factor in the germline alpha
, transcription factor FIGa
, class C basic helix-loop-helix protein 8
, folliculogenesis-specific basic helix-loop-helix protein
, folliculogenesis specific basic helix-loop-helix
, folliculogenesis specific bHLH transcription factor L homeolog